C209D_MOUSE
ID C209D_MOUSE Reviewed; 237 AA.
AC Q91ZW8; Q8VIK4;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=CD209 antigen-like protein D;
DE AltName: Full=DC-SIGN-related protein 3;
DE Short=DC-SIGNR3;
DE AltName: CD_antigen=CD209;
GN Name=Cd209d;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J;
RX PubMed=11581173; DOI=10.1093/intimm/13.10.1283;
RA Park C.G., Takahara K., Umemoto E., Yashima Y., Matsubara K., Matsuda Y.,
RA Clausen B.E., Inaba K., Steinman R.M.;
RT "Five mouse homologues of the human dendritic cell C-type lectin, DC-
RT SIGN.";
RL Int. Immunol. 13:1283-1290(2001).
CC -!- FUNCTION: Probable pathogen-recognition receptor. May mediate the
CC endocytosis of pathogens which are subsequently degraded in lysosomal
CC compartments. May recognize in a calcium-dependent manner high mannose
CC N-linked oligosaccharides in a variety of pathogen antigens.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q91ZW8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q91ZW8-2; Sequence=VSP_010071;
CC -!- CAUTION: In mouse, 5 genes homologous to human CD209/DC-SIGN and
CC CD209L/DC-SIGNR have been identified. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding;
CC Note=SIGNR3;
CC URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_00132";
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DR EMBL; AF373411; AAL13237.1; -; mRNA.
DR EMBL; AF440280; AAL33584.1; -; mRNA.
DR CCDS; CCDS22075.1; -. [Q91ZW8-1]
DR RefSeq; NP_570974.1; NM_130904.2. [Q91ZW8-1]
DR AlphaFoldDB; Q91ZW8; -.
DR SMR; Q91ZW8; -.
DR STRING; 10090.ENSMUSP00000011445; -.
DR GlyGen; Q91ZW8; 2 sites.
DR MaxQB; Q91ZW8; -.
DR PaxDb; Q91ZW8; -.
DR PRIDE; Q91ZW8; -.
DR ProteomicsDB; 265404; -. [Q91ZW8-1]
DR ProteomicsDB; 265405; -. [Q91ZW8-2]
DR DNASU; 170779; -.
DR Ensembl; ENSMUST00000011445; ENSMUSP00000011445; ENSMUSG00000031495. [Q91ZW8-1]
DR Ensembl; ENSMUST00000209176; ENSMUSP00000147198; ENSMUSG00000031495. [Q91ZW8-2]
DR GeneID; 170779; -.
DR KEGG; mmu:170779; -.
DR UCSC; uc009kst.1; mouse. [Q91ZW8-1]
DR UCSC; uc012fyv.1; mouse. [Q91ZW8-2]
DR CTD; 170779; -.
DR MGI; MGI:2157947; Cd209d.
DR VEuPathDB; HostDB:ENSMUSG00000031495; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000155012; -.
DR HOGENOM; CLU_049894_7_3_1; -.
DR InParanoid; Q91ZW8; -.
DR OMA; TSGMNFF; -.
DR PhylomeDB; Q91ZW8; -.
DR TreeFam; TF333341; -.
DR BioGRID-ORCS; 170779; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q91ZW8; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q91ZW8; protein.
DR Bgee; ENSMUSG00000031495; Expressed in lip and 34 other tissues.
DR ExpressionAtlas; Q91ZW8; baseline and differential.
DR Genevisible; Q91ZW8; MM.
DR GO; GO:0009897; C:external side of plasma membrane; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; ISS:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0030246; F:carbohydrate binding; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR GO; GO:0005537; F:mannose binding; IDA:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0001618; F:virus receptor activity; ISO:MGI.
DR GO; GO:0042742; P:defense response to bacterium; IMP:MGI.
DR GO; GO:0006897; P:endocytosis; IDA:MGI.
DR GO; GO:0001819; P:positive regulation of cytokine production; IDA:MGI.
DR CDD; cd03590; CLECT_DC-SIGN_like; 1.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR033989; CD209-like_CTLD.
DR InterPro; IPR016187; CTDL_fold.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Disulfide bond; Endocytosis; Glycoprotein;
KW Lectin; Mannose-binding; Membrane; Metal-binding; Receptor;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..237
FT /note="CD209 antigen-like protein D"
FT /id="PRO_0000046607"
FT TOPO_DOM 1..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..237
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 112..227
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT BINDING 196
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT BINDING 198
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT BINDING 203
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT BINDING 214
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT BINDING 215
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 129
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 106..117
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 134..226
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 205..218
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT VAR_SEQ 45..74
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11581173"
FT /id="VSP_010071"
SQ SEQUENCE 237 AA; 26925 MW; 52E3003C65AF8EF6 CRC64;
MSDSMESKTQ QVVIPEDEEC LMSGTRYSDI SSRLQTKFGI KSLAEYTKQS RNPLVLQLLS
FLFLAGLLLI ILILVSKVPS SEVQNKIYQE LMQLKAEVHD GLCQPCARDW TFFNGSCYFF
SKSQRNWHNS TTACQELGAQ LVIIETDEEQ TFLQQTSKAR GPTWMGLSDM HNEATWHWVD
GSPLSPSFTR YWNRGEPNNV GDEDCAEFSG DGWNDLSCDK LLFWICKKVS TSSCTTK
