ID   C22AA_BACTU             Reviewed;         722 AA.
AC   P56957;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Pesticidal crystal protein Cry22Aa;
DE   AltName: Full=79 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryXXIIA(a);
GN   Name=cry22Aa; Synonyms=cryXXIIA(a);
OS   Bacillus thuringiensis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1428;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NRRL B-18921 / PS211B2;
RA   Payne J.M., Kennedy M.K., Randall J.B., Meier H., Uick H.J., Foncerrada L.,
RA   Schnepf H.E., Schwab G.E., Fu J.M.;
RT   "Bacillus thuringiensis toxins active against hymenopteran pests.";
RL   Patent number US5596071, 21-JAN-1997.
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of hymenopteran species.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
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DR   EMBL; I34547; -; NOT_ANNOTATED_CDS; Unassigned_DNA.
DR   AlphaFoldDB; P56957; -.
DR   SMR; P56957; -.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 4.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR032179; Cry22Aa_Ig-like.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   Pfam; PF16403; DUF5011; 3.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..722
FT                   /note="Pesticidal crystal protein Cry22Aa"
FT                   /id="PRO_0000174098"
SQ   SEQUENCE   722 AA;  79250 MW;  532CEB708D9FAFF8 CRC64;
     MKEQNLNKYD EITVQAASDY IDIRPIFQTN GSATFNSNTN ITTLTQAINS QAGAIAGKTA
     LDMRHDFTFR ADIFLGTKSN GADGIAIAFH RGSIGFVGTK GGGLGILGAP KGIGFELDTY
     ANAPEDEVGD SFGHGAMKGS FPSFPNGYPH AGFVSTDKNS RWLSALAQMQ RIAAPNGRWR
     RLEIRWDARN KELTANLQDL TFNDITVGEK PRTPRTATWR LVNPAFELDQ KYTFVIGSAT
     GASNNLHQIG IIEFDAYFTK PTIEANNVNV PVGATFNPKT YPGINLRATD EIDGDLTSKI
     IVKANNVNTS KTGVYYVTYY VENSYGESDE KTIEVTVFSN PTIIASDVEI EKGESFNPLT
     DSRVGLSAQD SLGNDITQNV KVKSSNVDTS KPGEYEVVFE VTDSFGGKAE KDFKVTVLGQ
     PSIEANNVEL EIDDSLDPLT DAKVGLRAKD SLGNDITKDI KVKFNNVDTS NSGKYEVIFE
     VTDRFGKKAE KSIEVLVLGE PSIEANDVEV NKGETFEPLT DSRVGLRAKD SLGNDITKDV
     KIKSSNVDTS KPGEYEVVFE VTDRFGKYVE KTIGVIVPVI DDEWEDGNVN GWKFYAGQDI
     KLLKDPDKAY KGDYVFYDSR HVAISKTIPL TDLQINTNYE ITVYAKAESG DHHLKVTYKK
     DPAGPEEPPV FNRLISTGTL VEKDYRELKG TFRVTELNKA PLIIVENFGA GYIGGIRIVK
     IS