ID   ACBD4_PONAB             Reviewed;         269 AA.
AC   Q5R7P6;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Acyl-CoA-binding domain-containing protein 4;
GN   Name=ACBD4;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds medium- and long-chain acyl-CoA esters and may function
CC       as an intracellular carrier of acyl-CoA esters. {ECO:0000250}.
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DR   EMBL; CR860066; CAH92214.1; -; mRNA.
DR   RefSeq; NP_001127524.1; NM_001134052.2.
DR   AlphaFoldDB; Q5R7P6; -.
DR   SMR; Q5R7P6; -.
DR   STRING; 9601.ENSPPYP00000009339; -.
DR   Ensembl; ENSPPYT00000053415; ENSPPYP00000039901; ENSPPYG00000008311.
DR   GeneID; 100174600; -.
DR   KEGG; pon:100174600; -.
DR   CTD; 79777; -.
DR   eggNOG; KOG0817; Eukaryota.
DR   GeneTree; ENSGT00940000160739; -.
DR   InParanoid; Q5R7P6; -.
DR   OrthoDB; 1546859at2759; -.
DR   Proteomes; UP000001595; Chromosome 17.
DR   GO; GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   CDD; cd00435; ACBP; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   InterPro; IPR022408; Acyl-CoA-binding_prot_CS.
DR   InterPro; IPR000582; Acyl-CoA-binding_protein.
DR   InterPro; IPR035984; Acyl-CoA-binding_sf.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   Pfam; PF00887; ACBP; 1.
DR   PRINTS; PR00689; ACOABINDINGP.
DR   SUPFAM; SSF47027; SSF47027; 1.
DR   PROSITE; PS00880; ACB_1; 1.
DR   PROSITE; PS51228; ACB_2; 1.
PE   2: Evidence at transcript level;
KW   Lipid-binding; Phosphoprotein; Reference proteome.
FT   CHAIN           1..269
FT                   /note="Acyl-CoA-binding domain-containing protein 4"
FT                   /id="PRO_0000214033"
FT   DOMAIN          12..101
FT                   /note="ACB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00573"
FT   REGION          150..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          195..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          248..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..211
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         23..32
FT                   /ligand="an acyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:58342"
FT                   /evidence="ECO:0000250"
FT   BINDING         43..47
FT                   /ligand="an acyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:58342"
FT                   /evidence="ECO:0000250"
FT   BINDING         69
FT                   /ligand="an acyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:58342"
FT                   /evidence="ECO:0000250"
FT   BINDING         88
FT                   /ligand="an acyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:58342"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         166
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NC06"
FT   MOD_RES         171
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NC06"
SQ   SEQUENCE   269 AA;  29863 MW;  FA0D4EA739D4EBAC CRC64;
     MGTEKESPEP DCQKQFQAAV SVIQNLPKNG SYRPSYEEML RFYSYYKQAT MGPCLVPRPG
     FWDPIGRYKW DAWNSLGKMS REEAMSAYIT EMKLVAQKVI DTVPLGEVAE DMFAYFEPLY
     QVIPDMPRPP ETFLRRVTGW KEQVVNGDVG AVSEPPCLPK EPAPPSPESH SPRDLDSEVF
     CDSLEQLEPE LVWTEQRAAS GEKRDPRNSP VPPTEKEAAA QAQCSAMAPW APRARAALLP
     PVALRRPVAL PNVSDPKEVT VSGGVSAAN