ID   C24AA_BACTJ             Reviewed;         674 AA.
AC   O87905;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Pesticidal crystal protein Cry24Aa;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE            Short=Crystal protein;
DE   AltName: Full=Insecticidal delta-endotoxin CryXXIVA(a);
DE   AltName: Full=Insecticidal protein Jeg72;
DE   Flags: Fragment;
GN   Name=cry24Aa; Synonyms=cryXXIVA(a);
OS   Bacillus thuringiensis subsp. jegathesan.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=56955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kawalek M.D., Gill S.S.;
RT   "Isolation and characterization of insecticidal genes from Bacillus
RT   thuringiensis subsp. jegathesan.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of insects.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; U88188; AAC61891.1; -; Genomic_DNA.
DR   AlphaFoldDB; O87905; -.
DR   SMR; O87905; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   2: Evidence at transcript level;
KW   Sporulation; Toxin; Virulence.
FT   CHAIN           1..>674
FT                   /note="Pesticidal crystal protein Cry24Aa"
FT                   /id="PRO_0000174099"
FT   NON_TER         674
SQ   SEQUENCE   674 AA;  75959 MW;  DA3904DAB891C978 CRC64;
     MNQYQNKNEY EILESSQNNM NMPNRYPFAD DPNAVMKNGN YKDWVNECEG SNISPSPAAA
     ITSKIVSIVL KTLAKAVASS LADSIKSSLG ISKTITENNV SQVSMVQVHQ IINRRIQETI
     LDLGESSLNG LVAIYNRDYL GALEAWNNNK SNINYQTNVA EAFKTVEREF FTKLKGIYRT
     SSSQITLLPT FTQAANLHLS MLRDAVMYQE GWNLQSHINY SKELDDALED YTNYCVEVYT
     KGLNALRGST AIDWLEFNSF RRDMTLMVLD LVAIFPNYNP VRYPLSTKIS LSRKIYTDPV
     GRTDSPSFGD WTNTGRTLAN FNDLEREVTD SPSLVKWLGD MTIYTGAIDS YRPTSPGDRI
     GVWYGNINAF YHTGRTDVVM FRQTGDTAYE DPSTFISNIL YDDIYKLDLR AAAVSTIQGA
     MDTTFGVSSS RFFDIRGRNQ LYQSNKPYPS LPITITFPGE ESSEGNANDY SHLLCDVKIL
     QEDSSNICEG RSSLLSHAWT HASLDRNNTI LPDEITQIPA VTAYELRGNS SVVAGPGSTG
     GDLVKMSYHS VWSFKVYCSE LKNYRVRIRY ASHGNCQFLM KRWPSTGVAP RQWARHNVQG
     TFSNSMRYEA FKYLDIFTIT PEENNFAFTI DLESGGDLFI DKIEFIPVSG SAFEYEGKQN
     IEKTQKAVND LFIN