ID   C26AA_BACTF             Reviewed;        1163 AA.
AC   Q9X597;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Pesticidal crystal protein Cry26Aa;
DE   AltName: Full=131 kDa crystal protein;
DE   AltName: Full=Crystaline entomocidal protoxin;
DE   AltName: Full=Insecticidal delta-endotoxin CryXXVIA(a);
GN   Name=cry26Aa; Synonyms=cry26Aa1, cryXXVIA(a);
OS   Bacillus thuringiensis subsp. finitimus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=29337;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=VKPM B-1166;
RX   PubMed=10403372; DOI=10.1016/s0014-5793(99)00650-x;
RA   Wojciechowska J.A., Lewitin E., Revina L.P., Zalunin I.A.,
RA   Chestukhina G.G.;
RT   "Two novel delta-endotoxin gene families cry26 and cry28 from Bacillus
RT   thuringiensis ssp. finitimus.";
RL   FEBS Lett. 453:46-48(1999).
CC   -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut
CC       epithelial cells of insects.
CC   -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation
CC       and is accumulated both as an inclusion and as part of the spore coat.
CC   -!- MISCELLANEOUS: Toxic segment of the protein is located in the N-
CC       terminus.
CC   -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}.
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DR   EMBL; AF122897; AAD25075.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9X597; -.
DR   SMR; Q9X597; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0001897; P:cytolysis by symbiont of host cells; IEA:InterPro.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.190.10; -; 1.
DR   Gene3D; 2.100.10.10; -; 1.
DR   InterPro; IPR041587; Cry_V.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR038979; Pest_crys.
DR   InterPro; IPR005638; Pest_crys_C.
DR   InterPro; IPR005639; Pest_crys_N.
DR   InterPro; IPR036716; Pest_crys_N_sf.
DR   InterPro; IPR001178; Pest_cryst_cen_dom.
DR   InterPro; IPR036399; Pest_cryst_cen_dom_sf.
DR   PANTHER; PTHR37003; PTHR37003; 1.
DR   Pfam; PF17997; Cry1Ac_D5; 1.
DR   Pfam; PF03944; Endotoxin_C; 1.
DR   Pfam; PF00555; Endotoxin_M; 1.
DR   Pfam; PF03945; Endotoxin_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   SUPFAM; SSF51096; SSF51096; 1.
DR   SUPFAM; SSF56849; SSF56849; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Sporulation; Toxin; Virulence.
FT   CHAIN           1..1163
FT                   /note="Pesticidal crystal protein Cry26Aa"
FT                   /id="PRO_0000174101"
SQ   SEQUENCE   1163 AA;  131285 MW;  72B5D5EB51341908 CRC64;
     MNSEEMNHVN PFEISDNNDV SIPSQRYPFA NDPADSVFCA DDFLQSYGEF NMDNFGESEP
     FIDASGAINA AIGVTGTVLG FLGVPFAGAL TTFYQKLFGF LFPNNNTKQW EEFMKQVEAL
     IDEKISDAVR NKAISELQGL VNNITLYTEA LEEWLENKEN PAVRDRVLQR WRILDGFFEQ
     QMPSFAVKGF EVLLLVVYTQ AANLHLLSLR DAYIYGAEWG LTPTNIDQNH TRLLRHSAEY
     TDHCVNWYNT GLKQLENSDA KSWFQYNRFR REMTLSVLDV IALFPAYDVK MYPIPTNFQL
     TREVYTDVIG KIGRNDSDHW YSANAPSFSN LESTLIRTPH VVDYIKKLKI FYATVDYYGI
     YGRSGKWVGH IITSATSANT TETRNYGTIV NHDSVELNFE GKNIYKTGSL PQGVPPYQIG
     YVTPIYFITR AVNFFTVSGS KTSVEKYYSK KDRYYSEGLP EEQGVFSTEQ LPPNSIAEPE
     HIAYSHRLCH VTFISVSNGN KYSKDLPLFS WTHSSVDFDN YVYPTKITQL PATKGYNVSI
     VKEPGFIGGD IGKNNGQILG KYKVNVEDVS QKYRFRVRYA TETEGELGIK IDGRTVNLYQ
     YKKTKAPGDP LTYKAFDYLS FSTPVKFNNA SSTIELFLQN KTSGTFYLAG IEIIPVKSNY
     EEELTLEEAK KAVSSLFTDA RNALKIDVTD YQIDQAANLV ECISGDLYAK EKIVLLRAVK
     FAKQLSQSQN LLSDPEFNNV NRENSWTAST SVAIIEGDPL YKGRAVQLSS ARDENFPTYL
     YQKIDESTLK PYTRYQLRGF VEGSENLDVY LIRYGAAHVR MNVPYNLEII DTSSPVNPCE
     EVDGLSHRSC NVFDRCKQSI SVAPDANTGP DQIDGDPHAF SFHIDTGTVD STENLGIWVA
     FKISELDGSA IFGNLELIEV GPLSGEALAQ VQRKEEKWKQ VLAKKRETTA QTVCSGEASQ
     LTNSSQILKI RNYDLIQNFR IFSLRNTLSI KFKIYTITNY PYSRLNYDLF MELENRIQNA
     SLYMTSNILQ NGGFKSDVTS WETTANAEVQ QIDGASVLVL SNWNASVAQS VNVQNDHGYV
     LRVTAKKEGI GNGYVTILDC ANHIDTLTFS ACRSDSDTSS NELTAYVTKT LEIFPDTEQI
     RIEIGETEGM FYVESVELIR MEN