C28C1_DROME
ID C28C1_DROME Reviewed; 505 AA.
AC Q9VYT8; Q1WW98;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Probable cytochrome P450 28c1;
DE EC=1.14.-.-;
DE AltName: Full=CYPXXVIIIC1;
GN Name=Cyp28c1; ORFNames=CG1895;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in the metabolism of insect hormones and in
CC the breakdown of synthetic insecticides. {ECO:0000250}.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Peripheral membrane protein {ECO:0000305}. Microsome membrane
CC {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR EMBL; AE014298; AAF48100.1; -; Genomic_DNA.
DR EMBL; BT025008; ABE01238.1; -; mRNA.
DR RefSeq; NP_001259464.1; NM_001272535.1.
DR RefSeq; NP_572752.1; NM_132524.2.
DR AlphaFoldDB; Q9VYT8; -.
DR SMR; Q9VYT8; -.
DR IntAct; Q9VYT8; 5.
DR STRING; 7227.FBpp0305230; -.
DR PaxDb; Q9VYT8; -.
DR PRIDE; Q9VYT8; -.
DR DNASU; 32138; -.
DR EnsemblMetazoa; FBtr0073565; FBpp0073409; FBgn0030339.
DR EnsemblMetazoa; FBtr0333016; FBpp0305230; FBgn0030339.
DR GeneID; 32138; -.
DR KEGG; dme:Dmel_CG1895; -.
DR UCSC; CG1895-RA; d. melanogaster.
DR CTD; 32138; -.
DR FlyBase; FBgn0030339; Cyp28c1.
DR VEuPathDB; VectorBase:FBgn0030339; -.
DR eggNOG; KOG0158; Eukaryota.
DR GeneTree; ENSGT00940000167276; -.
DR HOGENOM; CLU_001570_5_2_1; -.
DR InParanoid; Q9VYT8; -.
DR OMA; IYPAGGW; -.
DR OrthoDB; 467733at2759; -.
DR PhylomeDB; Q9VYT8; -.
DR SignaLink; Q9VYT8; -.
DR BioGRID-ORCS; 32138; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 32138; -.
DR PRO; PR:Q9VYT8; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030339; Expressed in male reproductive gland and 7 other tissues.
DR ExpressionAtlas; Q9VYT8; baseline and differential.
DR Genevisible; Q9VYT8; DM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 1.10.630.10; -; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; SSF48264; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW Monooxygenase; Oxidoreductase; Reference proteome.
FT CHAIN 1..505
FT /note="Probable cytochrome P450 28c1"
FT /id="PRO_0000051989"
FT BINDING 444
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
SQ SEQUENCE 505 AA; 57410 MW; 8BF581609401A2C8 CRC64;
MFGSLLLGIA TLLGAIYAFL VSNFGHWRRR GVTEPRALPL FGSFPNMIWP RQHFTMDMRD
IYMHYRNTHS YVGCYLLRAP KLLVLEPRLV YEIYVSAFSH FENNDASKMV DIAKDRLVAL
NPFVLEGEEW RHQRAVFSTL LTNGRIRTTH AIMQRVCLDL CQFIAIKSAG GKDLDCIDLG
LRFTGESLFD CVLGIQARTF TDNPLPVVRQ NHEMSAENRG LAIAGAVHGL FPNLPRWLRP
KVFPRSHDRF YGQMISEALR LRRSKHQERN DFINHLLEMQ RELDLSEEDM ASHAMTFMFD
GLDTTSNSIA HCLLLLGRNP DCQRRLYEEL QLVNPGGYLP DLDALIDLPY LSACFNESLR
IYPAGGWASK TCTKEYELRG SHHSEPLKLR PGDHVMVPIY ALHNDPDLYP EPDVFRPERF
LDGGLKNCKQ QGIFLGFGNG PRQCVGMRLG LAMAKAALAA IVQRFEVVVS PRTLNGTELD
PLIFVGVHKG GIWLQFVPRK NVTTK
