C2AIL_HUMAN
ID C2AIL_HUMAN Reviewed; 116 AA.
AC Q96HQ2; Q8WVE3;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=CDKN2AIP N-terminal-like protein;
DE AltName: Full=CDKN2A-interacting protein N-terminal-like protein;
GN Name=CDKN2AIPNL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 1-28, ACETYLATION AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC TISSUE=Colon carcinoma;
RA Bienvenut W.V., Zebisch A., Kolch W.;
RL Submitted (DEC-2008) to UniProtKB.
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [5]
RP INTERACTION WITH XRN2, AND MUTAGENESIS OF TYR-81.
RX PubMed=26779609; DOI=10.1038/nsmb.3155;
RA Richter H., Katic I., Gut H., Grosshans H.;
RT "Structural basis and function of XRN2 binding by XTB domains.";
RL Nat. Struct. Mol. Biol. 23:164-171(2016).
CC -!- SUBUNIT: Interacts with XRN2; the interaction is direct.
CC {ECO:0000269|PubMed:26779609}.
CC -!- INTERACTION:
CC Q96HQ2; O95994: AGR2; NbExp=3; IntAct=EBI-10038935, EBI-712648;
CC Q96HQ2; P78358: CTAG1B; NbExp=3; IntAct=EBI-10038935, EBI-1188472;
CC Q96HQ2; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-10038935, EBI-741158;
CC Q96HQ2; Q9H0D6: XRN2; NbExp=2; IntAct=EBI-10038935, EBI-372110;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96HQ2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96HQ2-2; Sequence=VSP_032486;
CC -!- SIMILARITY: Belongs to the CARF family. {ECO:0000305}.
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DR EMBL; CH471062; EAW62260.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW62261.1; -; Genomic_DNA.
DR EMBL; BC008293; AAH08293.1; -; mRNA.
DR EMBL; BC018086; AAH18086.1; -; mRNA.
DR CCDS; CCDS4175.1; -. [Q96HQ2-1]
DR RefSeq; NP_542387.1; NM_080656.2. [Q96HQ2-1]
DR AlphaFoldDB; Q96HQ2; -.
DR SMR; Q96HQ2; -.
DR BioGRID; 124820; 26.
DR DIP; DIP-61982N; -.
DR IntAct; Q96HQ2; 15.
DR STRING; 9606.ENSP00000394183; -.
DR iPTMnet; Q96HQ2; -.
DR MetOSite; Q96HQ2; -.
DR PhosphoSitePlus; Q96HQ2; -.
DR BioMuta; CDKN2AIPNL; -.
DR DMDM; 74731962; -.
DR EPD; Q96HQ2; -.
DR jPOST; Q96HQ2; -.
DR MassIVE; Q96HQ2; -.
DR MaxQB; Q96HQ2; -.
DR PaxDb; Q96HQ2; -.
DR PeptideAtlas; Q96HQ2; -.
DR PRIDE; Q96HQ2; -.
DR ProteomicsDB; 76776; -. [Q96HQ2-1]
DR ProteomicsDB; 76777; -. [Q96HQ2-2]
DR TopDownProteomics; Q96HQ2-1; -. [Q96HQ2-1]
DR Antibodypedia; 64397; 40 antibodies from 10 providers.
DR DNASU; 91368; -.
DR Ensembl; ENST00000395009.3; ENSP00000378456.3; ENSG00000237190.4. [Q96HQ2-2]
DR Ensembl; ENST00000458198.3; ENSP00000394183.2; ENSG00000237190.4. [Q96HQ2-1]
DR GeneID; 91368; -.
DR KEGG; hsa:91368; -.
DR MANE-Select; ENST00000458198.3; ENSP00000394183.2; NM_080656.3; NP_542387.1.
DR UCSC; uc011cxs.3; human. [Q96HQ2-1]
DR CTD; 91368; -.
DR DisGeNET; 91368; -.
DR GeneCards; CDKN2AIPNL; -.
DR HGNC; HGNC:30545; CDKN2AIPNL.
DR HPA; ENSG00000237190; Tissue enhanced (skeletal).
DR neXtProt; NX_Q96HQ2; -.
DR OpenTargets; ENSG00000237190; -.
DR PharmGKB; PA162382150; -.
DR VEuPathDB; HostDB:ENSG00000237190; -.
DR eggNOG; ENOG502S4FT; Eukaryota.
DR GeneTree; ENSGT00940000157177; -.
DR HOGENOM; CLU_148771_0_0_1; -.
DR InParanoid; Q96HQ2; -.
DR OMA; EDPHLDH; -.
DR OrthoDB; 1524198at2759; -.
DR PhylomeDB; Q96HQ2; -.
DR TreeFam; TF333807; -.
DR PathwayCommons; Q96HQ2; -.
DR SignaLink; Q96HQ2; -.
DR BioGRID-ORCS; 91368; 28 hits in 1070 CRISPR screens.
DR ChiTaRS; CDKN2AIPNL; human.
DR GenomeRNAi; 91368; -.
DR Pharos; Q96HQ2; Tdark.
DR PRO; PR:Q96HQ2; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q96HQ2; protein.
DR Bgee; ENSG00000237190; Expressed in hindlimb stylopod muscle and 154 other tissues.
DR Genevisible; Q96HQ2; HS.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR InterPro; IPR021859; XTBD.
DR Pfam; PF11952; XTBD; 1.
DR PROSITE; PS51827; XTBD; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Direct protein sequencing;
KW Reference proteome.
FT CHAIN 1..116
FT /note="CDKN2AIP N-terminal-like protein"
FT /id="PRO_0000325926"
FT DOMAIN 24..116
FT /note="XRN2-binding (XTBD)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01171"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000269|Ref.3, ECO:0007744|PubMed:22814378"
FT VAR_SEQ 81..116
FT /note="YNKDLLDKVMEMADGIEVEDLPQFTTRSELMKKHQS -> PRGPK (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032486"
FT MUTAGEN 81
FT /note="Y->A: Abolishes binding to XRN2."
FT /evidence="ECO:0000269|PubMed:26779609"
SQ SEQUENCE 116 AA; 13196 MW; 26166C4274FE679C CRC64;
MVGGEAAAAV EELVSGVRQA ADFAEQFRSY SESEKQWKAR MEFILRHLPD YRDPPDGSGR
LDQLLSLSMV WANHLFLGCS YNKDLLDKVM EMADGIEVED LPQFTTRSEL MKKHQS
