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TRUB_RICFE
ID   TRUB_RICFE              Reviewed;         339 AA.
AC   Q4ULJ9;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 2.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=tRNA pseudouridine synthase B {ECO:0000255|HAMAP-Rule:MF_01080};
DE            EC=5.4.99.25 {ECO:0000255|HAMAP-Rule:MF_01080};
DE   AltName: Full=tRNA pseudouridine(55) synthase {ECO:0000255|HAMAP-Rule:MF_01080};
DE            Short=Psi55 synthase {ECO:0000255|HAMAP-Rule:MF_01080};
DE   AltName: Full=tRNA pseudouridylate synthase {ECO:0000255|HAMAP-Rule:MF_01080};
DE   AltName: Full=tRNA-uridine isomerase {ECO:0000255|HAMAP-Rule:MF_01080};
GN   Name=truB {ECO:0000255|HAMAP-Rule:MF_01080}; OrderedLocusNames=RF_0723;
OS   Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=315456;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1525 / URRWXCal2;
RX   PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA   Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA   Parinello H., Claverie J.-M., Raoult D.;
RT   "The genome sequence of Rickettsia felis identifies the first putative
RT   conjugative plasmid in an obligate intracellular parasite.";
RL   PLoS Biol. 3:1-12(2005).
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-55 in
CC       the psi GC loop of transfer RNAs. {ECO:0000255|HAMAP-Rule:MF_01080}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(55) in tRNA = pseudouridine(55) in tRNA;
CC         Xref=Rhea:RHEA:42532, Rhea:RHEA-COMP:10101, Rhea:RHEA-COMP:10102,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.25;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01080};
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase TruB family. Type 1
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01080}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAY61574.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000053; AAY61574.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_039594988.1; NC_007109.1.
DR   AlphaFoldDB; Q4ULJ9; -.
DR   SMR; Q4ULJ9; -.
DR   STRING; 315456.RF_0723; -.
DR   EnsemblBacteria; AAY61574; AAY61574; RF_0723.
DR   KEGG; rfe:RF_0723; -.
DR   eggNOG; COG0130; Bacteria.
DR   eggNOG; COG1565; Bacteria.
DR   HOGENOM; CLU_032087_0_3_5; -.
DR   OrthoDB; 1166299at2; -.
DR   Proteomes; UP000008548; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0106029; F:tRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:UniProtKB-UniRule.
DR   CDD; cd02573; PseudoU_synth_EcTruB; 1.
DR   HAMAP; MF_01080; TruB_bact; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR002501; PsdUridine_synth_N.
DR   InterPro; IPR005728; Rickett_RPE.
DR   InterPro; IPR014780; tRNA_psdUridine_synth_TruB.
DR   InterPro; IPR032819; TruB_C.
DR   PANTHER; PTHR13767; PTHR13767; 1.
DR   Pfam; PF16198; TruB_C_2; 1.
DR   Pfam; PF01509; TruB_N; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR01045; RPE1; 1.
DR   TIGRFAMs; TIGR00431; TruB; 1.
PE   3: Inferred from homology;
KW   Isomerase; tRNA processing.
FT   CHAIN           1..339
FT                   /note="tRNA pseudouridine synthase B"
FT                   /id="PRO_0000229379"
FT   DOMAIN          262..307
FT                   /note="RPE1 insert"
FT   ACT_SITE        40
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01080"
SQ   SEQUENCE   339 AA;  38192 MW;  DCFEFC3AB19590E6 CRC64;
     MNSYWLNIYK PRGISSAKLV SMVKKILGKE VKVGHAGTLD VEAEGILPLA VGEATKLIQL
     LIDAKKTYIF TVKFGTKTDS GDYAGTVIAT KDYIPSQEEA YNVCSKFIGN VTQIPPAFSA
     LKVNGVRAYK LAREGKEVEL KPRNITIYNL KCLNFDEKNA TASYYTECSK GTYIRTLAED
     LALSLQSLGF VIELRRTQVG IFKEENAIRI KSPDEITKNF LEEKSIKIEA ILDDILVLDA
     TDSQAQQIKY GQKCLFNYEE DFRRLSKFAY REEFEENTER STAAYTLVRE DANTGLTYKL
     PLEVELSVSL LWVRYKGNLL AIGSLNKSCF NSLRVFNLL
 
 
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