C2C4C_HUMAN
ID C2C4C_HUMAN Reviewed; 421 AA.
AC Q8TF44; Q8N3H7;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=C2 calcium-dependent domain-containing protein 4C;
DE AltName: Full=Nuclear-localized factor 3;
DE AltName: Full=Protein FAM148C;
GN Name=C2CD4C; Synonyms=FAM148C, KIAA1957, NLF3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=11853319; DOI=10.1093/dnares/8.6.319;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXII. The
RT complete sequences of 50 new cDNA clones which code for large proteins.";
RL DNA Res. 8:319-327(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-421.
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP IDENTIFICATION.
RX PubMed=15527968; DOI=10.1016/j.gene.2004.07.027;
RA Warton K., Foster N.C., Gold W.A., Stanley K.K.;
RT "A novel gene family induced by acute inflammation in endothelial cells.";
RL Gene 342:85-95(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- SIMILARITY: Belongs to the C2CD4 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB85543.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB075837; BAB85543.1; ALT_INIT; mRNA.
DR EMBL; AL834341; CAD39008.1; -; mRNA.
DR CCDS; CCDS45890.1; -.
DR RefSeq; NP_001129735.1; NM_001136263.1.
DR AlphaFoldDB; Q8TF44; -.
DR SMR; Q8TF44; -.
DR BioGRID; 126002; 14.
DR IntAct; Q8TF44; 2.
DR MINT; Q8TF44; -.
DR STRING; 9606.ENSP00000328677; -.
DR GlyGen; Q8TF44; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8TF44; -.
DR PhosphoSitePlus; Q8TF44; -.
DR SwissPalm; Q8TF44; -.
DR BioMuta; C2CD4C; -.
DR DMDM; 152032539; -.
DR EPD; Q8TF44; -.
DR jPOST; Q8TF44; -.
DR MassIVE; Q8TF44; -.
DR MaxQB; Q8TF44; -.
DR PaxDb; Q8TF44; -.
DR PeptideAtlas; Q8TF44; -.
DR PRIDE; Q8TF44; -.
DR ProteomicsDB; 74553; -.
DR Antibodypedia; 59205; 19 antibodies from 6 providers.
DR DNASU; 126567; -.
DR Ensembl; ENST00000332235.8; ENSP00000328677.4; ENSG00000183186.8.
DR GeneID; 126567; -.
DR KEGG; hsa:126567; -.
DR MANE-Select; ENST00000332235.8; ENSP00000328677.4; NM_001136263.2; NP_001129735.1.
DR UCSC; uc002loo.4; human.
DR CTD; 126567; -.
DR DisGeNET; 126567; -.
DR GeneCards; C2CD4C; -.
DR HGNC; HGNC:29417; C2CD4C.
DR HPA; ENSG00000183186; Tissue enriched (brain).
DR MIM; 610336; gene.
DR neXtProt; NX_Q8TF44; -.
DR OpenTargets; ENSG00000183186; -.
DR PharmGKB; PA165393218; -.
DR VEuPathDB; HostDB:ENSG00000183186; -.
DR eggNOG; ENOG502QT01; Eukaryota.
DR GeneTree; ENSGT00940000161259; -.
DR HOGENOM; CLU_051964_0_0_1; -.
DR InParanoid; Q8TF44; -.
DR OMA; LMSPGRY; -.
DR OrthoDB; 737753at2759; -.
DR PhylomeDB; Q8TF44; -.
DR TreeFam; TF330989; -.
DR PathwayCommons; Q8TF44; -.
DR BioGRID-ORCS; 126567; 13 hits in 1069 CRISPR screens.
DR GenomeRNAi; 126567; -.
DR Pharos; Q8TF44; Tdark.
DR PRO; PR:Q8TF44; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8TF44; protein.
DR Bgee; ENSG00000183186; Expressed in cingulate cortex and 105 other tissues.
DR Genevisible; Q8TF44; HS.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR Gene3D; 2.60.40.150; -; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR043549; C2C4C/C2C4D.
DR InterPro; IPR030533; C2CD4.
DR PANTHER; PTHR46291; PTHR46291; 1.
DR PANTHER; PTHR46291:SF5; PTHR46291:SF5; 1.
DR Pfam; PF00168; C2; 1.
DR SMART; SM00239; C2; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR PROSITE; PS50004; C2; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..421
FT /note="C2 calcium-dependent domain-containing protein 4C"
FT /id="PRO_0000293734"
FT DOMAIN 305..421
FT /note="C2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT REGION 13..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 262
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5HZI2"
FT MOD_RES 264
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5HZI2"
FT MOD_RES 273
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
SQ SEQUENCE 421 AA; 44576 MW; 0CB73547E08571BD CRC64;
MRKTNMWFLE RLRGSGENGA ARGVGSEAGD KASKGPLYSN VLTPDKIPDF FIPPKLPSGP
AEGEGQAALG PSTSEQNLAS AAPRQTPRSP RLPAKLAAES KSLLKAATRH VIQIESAEDW
LSEEATDADP QAQGAMSLPS VPKAQTSYGF AMLAESPHTR RKESLFHSEH GALAQVGSPG
AGRRRAAAKA NGGDGGPREA GGALMSPGRY FSGGESDTGS SAESSPFGSP LLSRSVSLLK
GFAQDSQAKV SQLRHSVGRH GSLSADDSTP DASPGSRRRL TRRAPPEPGP ESGQARGEHT
VHVGPRGSVR LLAEYEAGQA RLRVHLLAAE GLYDRLCDAR SINCCVGLCL VPGKLQKQRS
TIVKNSRRPV FNEDFFFDGL GPASVRKLAL RIKVVNKGSS LKRDTLLGEK ELPLTSLLPF
L
