C2C4C_MOUSE
ID C2C4C_MOUSE Reviewed; 419 AA.
AC Q5HZI2; Q8CDK0;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=C2 calcium-dependent domain-containing protein 4C;
DE AltName: Full=Nuclear-localized factor 3;
DE AltName: Full=Protein FAM148C;
GN Name=C2cd4c; Synonyms=Fam148c, Nlf3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259 AND SER-261, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the C2CD4 family. {ECO:0000305}.
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DR EMBL; AK029946; BAC26694.1; -; mRNA.
DR EMBL; BC089008; AAH89008.1; -; mRNA.
DR CCDS; CCDS23979.1; -.
DR RefSeq; NP_001162095.1; NM_001168624.1.
DR RefSeq; NP_941016.2; NM_198614.3.
DR AlphaFoldDB; Q5HZI2; -.
DR SMR; Q5HZI2; -.
DR STRING; 10090.ENSMUSP00000059433; -.
DR iPTMnet; Q5HZI2; -.
DR PhosphoSitePlus; Q5HZI2; -.
DR SwissPalm; Q5HZI2; -.
DR MaxQB; Q5HZI2; -.
DR PaxDb; Q5HZI2; -.
DR PeptideAtlas; Q5HZI2; -.
DR PRIDE; Q5HZI2; -.
DR ProteomicsDB; 265463; -.
DR Antibodypedia; 59205; 19 antibodies from 6 providers.
DR DNASU; 237397; -.
DR Ensembl; ENSMUST00000059699; ENSMUSP00000059433; ENSMUSG00000045912.
DR Ensembl; ENSMUST00000178228; ENSMUSP00000136013; ENSMUSG00000045912.
DR GeneID; 237397; -.
DR KEGG; mmu:237397; -.
DR UCSC; uc007fzb.2; mouse.
DR CTD; 126567; -.
DR MGI; MGI:2685084; C2cd4c.
DR VEuPathDB; HostDB:ENSMUSG00000045912; -.
DR eggNOG; ENOG502QT01; Eukaryota.
DR GeneTree; ENSGT00940000161259; -.
DR HOGENOM; CLU_051964_0_0_1; -.
DR InParanoid; Q5HZI2; -.
DR OMA; LMSPGRY; -.
DR OrthoDB; 737753at2759; -.
DR PhylomeDB; Q5HZI2; -.
DR TreeFam; TF330989; -.
DR BioGRID-ORCS; 237397; 1 hit in 74 CRISPR screens.
DR PRO; PR:Q5HZI2; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q5HZI2; protein.
DR Bgee; ENSMUSG00000045912; Expressed in dentate gyrus of hippocampal formation granule cell and 67 other tissues.
DR Genevisible; Q5HZI2; MM.
DR GO; GO:0005829; C:cytosol; IDA:MGI.
DR Gene3D; 2.60.40.150; -; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR043549; C2C4C/C2C4D.
DR InterPro; IPR030533; C2CD4.
DR PANTHER; PTHR46291; PTHR46291; 1.
DR PANTHER; PTHR46291:SF5; PTHR46291:SF5; 1.
DR Pfam; PF00168; C2; 1.
DR SMART; SM00239; C2; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR PROSITE; PS50004; C2; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..419
FT /note="C2 calcium-dependent domain-containing protein 4C"
FT /id="PRO_0000293735"
FT DOMAIN 303..419
FT /note="C2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT REGION 1..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 259
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 261
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 270
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TF44"
FT CONFLICT 120
FT /note="E -> D (in Ref. 1; BAC26694)"
FT /evidence="ECO:0000305"
FT CONFLICT 139
FT /note="P -> H (in Ref. 1; BAC26694)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 419 AA; 44614 MW; DF5C310C69A52920 CRC64;
MRKTNMWFLE RLRGSGENGA SRGEAGDKSS KGPLYSNVLT PDKIPDFFIP PKLPSGPTEA
EGQADLGPST SEQNLASPGP RRAPRSPRLP AKLASESRSL LKAATRHVIQ IESAEDWTAE
EATNADPQAQ GAMSLPSVPK AQTSYGFATL AESPHTRRKE SLFHSEHGAL AQVGSPGAGR
RRAGAKGNGG DGGSREVGGA LMSPSRYFSG GESDTGSSAE SSPFGSPLLS RSVSLLKGFA
QDSQAKVSQL KQSVGRHGSL SADDSTPDTS PGVRRRLSRR ATPEPGPESG QAPRGEHTVK
MGTRGSVRLL AEYEAAQARL RVRLLAAEGL YDRPCDARSI NCCVGLCLVP GKLQKQRSTI
IKNSRHPIFN EDFFFDGLGP ASVRKLALRI KVVNKGSSLK RDTLLGEEEL PLTSLLPFL
