C2CD2_MOUSE
ID C2CD2_MOUSE Reviewed; 696 AA.
AC E9Q3C1; Q3TE01; Q3UP20; Q5DTR6; Q80XM8;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=C2 domain-containing protein 2;
GN Name=C2cd2 {ECO:0000312|MGI:MGI:1891883};
GN Synonyms=Kiaa4045 {ECO:0000303|Ref.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. the
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mixed;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-582.
RC STRAIN=C57BL/6J; TISSUE=Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-581, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54 AND SER-581, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD90483.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK220454; BAD90483.1; ALT_INIT; mRNA.
DR EMBL; AC121560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC226122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466602; EDL03644.1; -; Genomic_DNA.
DR EMBL; BC043688; AAH43688.1; -; mRNA.
DR EMBL; AK143875; BAE25577.1; -; mRNA.
DR EMBL; AK169902; BAE41447.1; -; mRNA.
DR CCDS; CCDS28361.1; -.
DR RefSeq; NP_777272.2; NM_174847.2.
DR AlphaFoldDB; E9Q3C1; -.
DR STRING; 10090.ENSMUSP00000127368; -.
DR iPTMnet; E9Q3C1; -.
DR PhosphoSitePlus; E9Q3C1; -.
DR jPOST; E9Q3C1; -.
DR MaxQB; E9Q3C1; -.
DR PaxDb; E9Q3C1; -.
DR PeptideAtlas; E9Q3C1; -.
DR PRIDE; E9Q3C1; -.
DR ProteomicsDB; 265464; -.
DR Antibodypedia; 23680; 61 antibodies from 11 providers.
DR Ensembl; ENSMUST00000170757; ENSMUSP00000127368; ENSMUSG00000045975.
DR GeneID; 207781; -.
DR KEGG; mmu:207781; -.
DR UCSC; uc008ads.2; mouse.
DR CTD; 25966; -.
DR MGI; MGI:1891883; C2cd2.
DR VEuPathDB; HostDB:ENSMUSG00000045975; -.
DR eggNOG; ENOG502QV5U; Eukaryota.
DR GeneTree; ENSGT00530000063764; -.
DR HOGENOM; CLU_024872_0_0_1; -.
DR InParanoid; E9Q3C1; -.
DR OMA; EFIFELN; -.
DR OrthoDB; 890695at2759; -.
DR PhylomeDB; E9Q3C1; -.
DR TreeFam; TF331604; -.
DR BioGRID-ORCS; 207781; 2 hits in 70 CRISPR screens.
DR ChiTaRS; C2cd2; mouse.
DR PRO; PR:E9Q3C1; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; E9Q3C1; protein.
DR Bgee; ENSMUSG00000045975; Expressed in hindlimb stylopod muscle and 213 other tissues.
DR ExpressionAtlas; E9Q3C1; baseline and differential.
DR Genevisible; E9Q3C1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.150; -; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR039934; C2CD2/C2CD2L.
DR InterPro; IPR040885; SMP_C2CD2L.
DR PANTHER; PTHR21119; PTHR21119; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF18696; SMP_C2CD2L; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR PROSITE; PS50004; C2; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..696
FT /note="C2 domain-containing protein 2"
FT /id="PRO_0000439647"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 45..238
FT /note="SMP-LBD"
FT /evidence="ECO:0000305"
FT DOMAIN 241..357
FT /note="C2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT REGION 551..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 54
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 436
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y426"
FT MOD_RES 440
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y426"
FT MOD_RES 581
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT CONFLICT 83
FT /note="A -> S (in Ref. 5; BAE41447)"
FT /evidence="ECO:0000305"
FT CONFLICT 196
FT /note="K -> N (in Ref. 5; BAE41447)"
FT /evidence="ECO:0000305"
FT CONFLICT 197
FT /note="Q -> K (in Ref. 1; BAD90483, 3; AAH43688, 4;
FT EDL03644 and 5; BAE41447)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 696 AA; 76536 MW; 75C92EA0AF01D4FD CRC64;
MGSWLSEVQW LFLVSLFVAA LGTVGLYLAQ WALAKARPPP RRRAEPDELR RRESDTLLSW
ILTRDSWGNQ WQAAWVTALN YEAEKRGGPL RLSFQKDPRP QSLQLTVEKV SSVVKSTQEK
VVICHVVGET LQFLVSAGPA SATGSECQLY DVHLSPFHLK VEFHMEEKRE DIQIRWSFTH
VPETAIKIQP QAPGEKQALG VNMLSEALED LFKHLVNAAS PSVFLSTKPT QVKEAQSLQC
PSSTAQEPCP PKPPRAHELK LQVKNIRVSL INHPGASGLS HVCVAQLNDP EQRFISTLVR
NTTDLSWEEE FTFELNAKSK ELVLQISQDG CSSEGLLGIA TIHLDLFRKQ PNGPQTFRLI
SGTEPDSLVL GSVTAEFSYV EPGELKSWPA PPPVSAAKIE KDRTVMPCGT VVTTVTAVKT
KPRFDTGRAT PLNSESPVRT PVTVKVIEKD ISVQAISCHS APVSKTFSSS DTELLVLNGS
DPVAEVAIRQ LSESSKLKLK SPRKKSTIII SGISKTSLSQ DHNAALMLDY AASMDSTNQG
DATSALCHPE ATEASATTPP EENEPAQTLP ALKPRENDLD SWELEKESPV ASWSGPALQE
PDGDELSESS LSTSELGAMK KHKGGLLRKG AKLFFRRRHQ QKDPGLSQSH NDLVFLQQPE
GRQKKGATLG RLLNRKLLTR HRGKHTMNGV PREPCI
