C2CD3_XENTR
ID C2CD3_XENTR Reviewed; 2311 AA.
AC A0JM13; F7AQ82; F7AX60; F7BQ67;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 2.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=C2 domain-containing protein 3;
GN Name=c2cd3;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the centrioles that acts as a positive regulator
CC of centriole elongation. Promotes assembly of centriolar distal
CC appendage, a structure at the distal end of the mother centriole that
CC acts as an anchor of the cilium. Required for primary cilium formation
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center,
CC centrosome, centriole {ECO:0000250}. Note=Localizes to centriolar
CC satellites. Also localizes to the distal ends of the mother and
CC daughter centrioles (By similarity). {ECO:0000250}.
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DR EMBL; AAMC01126305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01126306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01126307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01126308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01126309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01126310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01126311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC125698; AAI25699.1; -; mRNA.
DR RefSeq; NP_001072727.1; NM_001079259.1.
DR AlphaFoldDB; A0JM13; -.
DR STRING; 8364.ENSXETP00000055765; -.
DR PaxDb; A0JM13; -.
DR PRIDE; A0JM13; -.
DR GeneID; 780184; -.
DR KEGG; xtr:780184; -.
DR CTD; 26005; -.
DR Xenbase; XB-GENE-5904944; c2cd3.
DR eggNOG; ENOG502QRQ8; Eukaryota.
DR InParanoid; A0JM13; -.
DR OrthoDB; 88005at2759; -.
DR TreeFam; TF323591; -.
DR Reactome; R-XTR-5620912; Anchoring of the basal body to the plasma membrane.
DR Proteomes; UP000008143; Chromosome 2.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0034451; C:centriolar satellite; ISS:UniProtKB.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0061511; P:centriole elongation; ISS:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:1905515; P:non-motile cilium assembly; ISS:UniProtKB.
DR GO; GO:0071539; P:protein localization to centrosome; ISS:UniProtKB.
DR CDD; cd08683; C2_C2cd3; 1.
DR Gene3D; 2.60.40.150; -; 2.
DR InterPro; IPR037775; C2_C2CD3.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR Pfam; PF00168; C2; 3.
DR SMART; SM00239; C2; 4.
DR SUPFAM; SSF49562; SSF49562; 3.
DR PROSITE; PS50004; C2; 6.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW Cytoskeleton; Reference proteome; Repeat.
FT CHAIN 1..2311
FT /note="C2 domain-containing protein 3"
FT /id="PRO_0000311241"
FT DOMAIN 508..666
FT /note="C2 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 751..888
FT /note="C2 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 952..1112
FT /note="C2 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 1136..1303
FT /note="C2 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 1370..1505
FT /note="C2 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 1581..1713
FT /note="C2 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT REGION 447..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1536..1589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1955..1977
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2036..2065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2084..2233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2261..2292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1561..1586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2084..2099
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2107..2121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2160..2179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2268..2292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 16..17
FT /note="IL -> SK (in Ref. 2; AAI25699)"
FT /evidence="ECO:0000305"
FT CONFLICT 26
FT /note="T -> S (in Ref. 2; AAI25699)"
FT /evidence="ECO:0000305"
FT CONFLICT 92
FT /note="R -> L (in Ref. 2; AAI25699)"
FT /evidence="ECO:0000305"
FT CONFLICT 510
FT /note="R -> K (in Ref. 2; AAI25699)"
FT /evidence="ECO:0000305"
FT CONFLICT 1741
FT /note="T -> A (in Ref. 2; AAI25699)"
FT /evidence="ECO:0000305"
FT CONFLICT 2094
FT /note="R -> G (in Ref. 2; AAI25699)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2311 AA; 255224 MW; FC9CE307B061B04D CRC64;
MKSRKVKSVR PGRGRILGLT DVTPSTSLPP LVEGQVRSFL QVTVSKILWT VPKPPPSVLV
RLRWWGETAN GTVFRPRDSS QTEQKGAKTT TRYAVRCGPK QFTSYLTDMG MLVFEVMTKL
DHFPIGRAQI SGIAQLSLAH PVSGFFTIVS PTSEKLGELQ VSVQLEPLPE TYDSSSSAPN
TDISFDHASE SYGKALTGHP TTMNDPPQPI ILSLASADKR ESESSSRVTT PRGRDHLYFQ
ENADPGKDSY RGTQDHVTVG WSNVTEGVQS IKPIYSEGTT AGKDALTVNS GPATKDLLSA
LLDQGSKLRD AMVVSALKSS PDLDHNPDIK LPLALNNYSL SQARATSEIP SPTLMRNLLN
SRHSPQTRDI LLQPADSFIP DMEAPSDAKA IELLLGSSVL SPGHYWDGTG SPPESISGSD
FYNESELNDP LYDQSLLEKL FYKAPKSDSS ASDFMSDDEN TRSQNKKNKI ALDRGRHRDN
SPSEYKEDAK QTKGNDSLRD SKTSEKSTSR CEGISLSMDQ AALLGQIHVA HVVVESLRVP
LDGTAVTPSK TNSRGRPPRP VRPAKQTFFV EFQFPVLSKS RSGEVNSATE ITRLVSSKVV
NGSIKFQQRF TFPVLFSGQM IKHWWNTDLT FRIFLRKGTQ NKPGPVGSAT LPLRDVLQSP
GLSVTCSLPV SCTAEDSHTA AGPLKISVAL AGDNKNIHDI SEKTLEPENQ APVLPAVTSK
AELENSASYT DLRPVAEKSS PLRQSLPPHI GNGGPKVSFS QNPQQTAEED GLLLHIVLMV
PEGKGLVAAG GDSSGICNSY LNCKLFSAQE ATRSSVVWGS TQPQYNFSQV APLTLNARLL
ERMKNNVMII EIWNRVASPG QDQLLGLAKL PLHQFYMSFS DPKITRLLLQ AQYPVVAVDS
YVPIIDVFSG CDRGKLKVLL AIGSGDQVVA LQRLKNEEGT SQTAMPRPAH FLDPPLSSSQ
MGRPQEGMTD HIFEIHVENV KGLTPLQSTV WGEADCFVQY YFPAHGPDSH TAIDLPEIAM
TLKPVRTATT LCVPDPVFND RQSHTIVAQS DTPVQRLLLG AYSMQGLSGG GGVPFEIWCR
YYYPNVRDQM VAKGVLPLSR LCAMVTMQHR EDVGIQAFSL PLIPRSEKSA ELPPQPSGLL
NVNVTYRRSM RNPVGMLATR MASISVQIHR ASGLQAAARL VAQQDASFQY SADVGVNAYV
TIHPAFLPDV ELRNTRTVAR TFCPEFDHHY EFPCNMVIQR NNGEACSLAE VLYFSEIVLS
IHHQNVASVG STRPQPVRDY HLGMVRIPCR QLITKRSGVS GWYPVTVPED SKLPTDSTIL
HSVVGGLELS VHFAHHSDRD RVLEVARGLG WNEYNEDFQE AIATEADEWH KREDLVNLSV
NIPKIWLPLH CLLLAGHKHI HKSTYCYLRY KFYDREAVCS PLRRPRLSED GQQATIMFEL
SENRELIKHQ PLVWYLREER MEIQVWRSYG KDTNGPRPQD TDRLIGCAYV DLKALSENTS
RTLAVSGVYP LFKRNVSSLW GAAVRVHLAL SSAYHPSNSS RRLSCAGERS QSEGEEWAPT
SGDSFEEKQD DSAKNDKPEA KTEVPLLDAK EQPVGEVDLK NTFAASIVVE RAMHLSLKGT
PLTERAAATP TCCVSYPVAG CSEPVTTPVI ANTDSPLWNF QHQARLHKEL LLDPQQRLVF
KVWHKTDVER VVGFASVDLS PLLSGFQSIC GWYNIVDFVG QCQGQVKVSI TPLEGVAHLK
TKVTSQRSSS YQSRPAFCSS FSYNPSQSEV PAFIPHIPTL HHQLSDRENS GPLFPFLRHE
EHMENVRRFH ESLQQAERNA HTVEGLDSLS QSSRSSLLSA LRKNLGELDE IQKYFNQKLY
RSISNAETSR CASVQIPQVQ PPNSEPAEED SDAKMLLQKS SFLVSQVSNL ITGLQGIPKF
APAFSSTEQR LDVQGQTSVQ HQQVDNMEPM APERSEAYER EGQRSDTPPF SPLGSLNVSG
EKLMEFIGTD MDEKERHLFA EKHQEEQDKH IIHGSSDEEY EEDVIEPRTL NEITTMTDRT
SPWSSILSER DSDSMDHPQD QPVNPLAAEN NRVITDFFSS FHQNDPSSVL SSARSTDSEV
LAEGSRVRKI SSSSGSEAET VGVQLSVDPA EQGALGEAES EAESQEMDGD PEANRTEEEQ
QDPVTVFSAL SSGSDESEHI TYGASEPDCS PPQDEPETDY PCSEPLEGNM HHIDEEEQPA
GSESPQVPPS NLLSDPVIVP NFFLPPQHLE ASMRHLSLSA VREGRSDTPG IPFRRSKRQK
PRLAPADLPK EETNRIARIF AAQFPGPPTP P
