ID   TRUC_HAEDU              Reviewed;         243 AA.
AC   P59840;
DT   09-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   09-SEP-2003, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=tRNA pseudouridine synthase C;
DE            EC=5.4.99.26;
DE   AltName: Full=tRNA pseudouridine(65) synthase;
DE   AltName: Full=tRNA pseudouridylate synthase C;
DE   AltName: Full=tRNA-uridine isomerase C;
GN   Name=truC; OrderedLocusNames=HD_1138;
OS   Haemophilus ducreyi (strain 35000HP / ATCC 700724).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=233412;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=35000HP / ATCC 700724;
RA   Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L.,
RA   Nguyen D., Wang J., Forst C., Hood L.;
RT   "The complete genome sequence of Haemophilus ducreyi.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-65 in
CC       transfer RNAs. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(65) in tRNA = pseudouridine(65) in tRNA;
CC         Xref=Rhea:RHEA:42536, Rhea:RHEA-COMP:10103, Rhea:RHEA-COMP:10104,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.26;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
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DR   EMBL; AE017143; AAP95999.1; -; Genomic_DNA.
DR   RefSeq; WP_010945048.1; NC_002940.2.
DR   AlphaFoldDB; P59840; -.
DR   SMR; P59840; -.
DR   STRING; 233412.HD_1138; -.
DR   EnsemblBacteria; AAP95999; AAP95999; HD_1138.
DR   KEGG; hdu:HD_1138; -.
DR   eggNOG; COG0564; Bacteria.
DR   HOGENOM; CLU_016902_11_4_6; -.
DR   OMA; DRHETQF; -.
DR   Proteomes; UP000001022; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0106029; F:tRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome; tRNA processing.
FT   CHAIN           1..243
FT                   /note="tRNA pseudouridine synthase C"
FT                   /id="PRO_0000162714"
FT   ACT_SITE        55
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   243 AA;  28575 MW;  CB4CEB57257F45ED CRC64;
     MELDILYRDD ELIAINKPAG MLVHRSWLDK AETLFAMQTL RDQINQHVFP IHRLDRPTSG
     VLLFALNSEM ARLMSEQFEQ HKVEKEYLAI VRGYIAEKGE IDYPLKVILD KIADKFSQPK
     AAQQAVTFYQ NLAKVEMPYS TGKYATTRYS LVALSPKTGR KHQLRRHMKH LFHPIMGDTK
     YGDLHQNRRL TEKTGCNRLM LHARLLHFTH PKTLQKITIS ALLDQQWQML FNQFGWHFTD
     FFY