TRUC_PASMU
ID TRUC_PASMU Reviewed; 243 AA.
AC Q9CNF3;
DT 09-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=tRNA pseudouridine synthase C;
DE EC=5.4.99.26;
DE AltName: Full=tRNA pseudouridine(65) synthase;
DE AltName: Full=tRNA pseudouridylate synthase C;
DE AltName: Full=tRNA-uridine isomerase C;
GN Name=truC; OrderedLocusNames=PM0479;
OS Pasteurella multocida (strain Pm70).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Pasteurella.
OX NCBI_TaxID=272843;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pm70;
RX PubMed=11248100; DOI=10.1073/pnas.051634598;
RA May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT "Complete genomic sequence of Pasteurella multocida Pm70.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-65 in
CC transfer RNAs. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=uridine(65) in tRNA = pseudouridine(65) in tRNA;
CC Xref=Rhea:RHEA:42536, Rhea:RHEA-COMP:10103, Rhea:RHEA-COMP:10104,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.26;
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE004439; AAK02563.1; -; Genomic_DNA.
DR RefSeq; WP_005721821.1; NC_002663.1.
DR AlphaFoldDB; Q9CNF3; -.
DR SMR; Q9CNF3; -.
DR STRING; 747.DR93_1259; -.
DR EnsemblBacteria; AAK02563; AAK02563; PM0479.
DR KEGG; pmu:PM0479; -.
DR HOGENOM; CLU_016902_11_4_6; -.
DR OMA; DRHETQF; -.
DR Proteomes; UP000000809; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0106029; F:tRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; SSF55120; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
PE 3: Inferred from homology;
KW Isomerase; Reference proteome; tRNA processing.
FT CHAIN 1..243
FT /note="tRNA pseudouridine synthase C"
FT /id="PRO_0000162716"
FT ACT_SITE 55
FT /evidence="ECO:0000250"
SQ SEQUENCE 243 AA; 28242 MW; 551AA3C71AA656C4 CRC64;
MTLEILYQDP YLIAVNKPAG MLVHRSWLDR HETQFVMQTL RDQIGQHVYP IHRLDRPTSG
VLLFALSSEV ANLLCLQFEN KQVQKSYLAI VRGYLVGEGR IDYPLKVQLD KIADKFAQDD
KAPQEAVTDY LGLAKVEMPY CVKKYPTTRY SLVRLIPHTG RKHQLRRHMK HLFHPILGDT
QYGDLHQNRA LTTHTGVQRL MLHAERLIFT HPITQQQITI CAGVDQQWLD LINIFDWDLN
SIH