TRUC_SALTI
ID TRUC_SALTI Reviewed; 260 AA.
AC Q8Z439;
DT 09-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=tRNA pseudouridine synthase C;
DE EC=5.4.99.26;
DE AltName: Full=tRNA pseudouridine(65) synthase;
DE AltName: Full=tRNA pseudouridylate synthase C;
DE AltName: Full=tRNA-uridine isomerase C;
GN Name=truC; OrderedLocusNames=STY3103, t2873;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-65 in
CC transfer RNAs. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=uridine(65) in tRNA = pseudouridine(65) in tRNA;
CC Xref=Rhea:RHEA:42536, Rhea:RHEA-COMP:10103, Rhea:RHEA-COMP:10104,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.26;
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC {ECO:0000305}.
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DR EMBL; AL513382; CAD06078.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO70429.1; -; Genomic_DNA.
DR RefSeq; NP_457360.1; NC_003198.1.
DR RefSeq; WP_000890022.1; NZ_WSUR01000005.1.
DR AlphaFoldDB; Q8Z439; -.
DR SMR; Q8Z439; -.
DR STRING; 220341.16504044; -.
DR EnsemblBacteria; AAO70429; AAO70429; t2873.
DR KEGG; stt:t2873; -.
DR KEGG; sty:STY3103; -.
DR PATRIC; fig|220341.7.peg.3158; -.
DR eggNOG; COG0564; Bacteria.
DR HOGENOM; CLU_016902_11_4_6; -.
DR OMA; DRHETQF; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0106029; F:tRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; SSF55120; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
PE 3: Inferred from homology;
KW Isomerase; tRNA processing.
FT CHAIN 1..260
FT /note="tRNA pseudouridine synthase C"
FT /id="PRO_0000162717"
FT ACT_SITE 54
FT /evidence="ECO:0000250"
SQ SEQUENCE 260 AA; 30055 MW; 827D2272AD4C0B31 CRC64;
MLEILYQDPW LVAVNKPAGW LVHRSWLDRD EKVVVMQTVR DQIGQHVFTA HRLDRPTSGV
LLMGLSSEAG RRLAQQFEQH HIRKRYHAIV RGWLIDDAVL DYPLVEERDK IADKFAREDK
APQPAVTQYR GLATVEMAVP TGRYPTTRYG LVELEPKTGR KHQLRRHLAH LRHPIIGDSK
HGDLRQNRSA AEHFACRRLM LHASRLELTH PFTGQPLIIQ AGLDETWMQV LTQFGWRGLL
PDNERVEFTA ASRQDETHLT
