TRUC_SALTY
ID TRUC_SALTY Reviewed; 260 AA.
AC Q8ZMD5;
DT 09-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=tRNA pseudouridine synthase C;
DE EC=5.4.99.26;
DE AltName: Full=tRNA pseudouridine(65) synthase;
DE AltName: Full=tRNA pseudouridylate synthase C;
DE AltName: Full=tRNA-uridine isomerase C;
GN Name=truC; OrderedLocusNames=STM2964;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-65 in
CC transfer RNAs. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=uridine(65) in tRNA = pseudouridine(65) in tRNA;
CC Xref=Rhea:RHEA:42536, Rhea:RHEA-COMP:10103, Rhea:RHEA-COMP:10104,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.26;
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC {ECO:0000305}.
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DR EMBL; AE006468; AAL21844.1; -; Genomic_DNA.
DR RefSeq; NP_461885.1; NC_003197.2.
DR RefSeq; WP_000890027.1; NC_003197.2.
DR AlphaFoldDB; Q8ZMD5; -.
DR SMR; Q8ZMD5; -.
DR STRING; 99287.STM2964; -.
DR PaxDb; Q8ZMD5; -.
DR EnsemblBacteria; AAL21844; AAL21844; STM2964.
DR GeneID; 1254487; -.
DR KEGG; stm:STM2964; -.
DR PATRIC; fig|99287.12.peg.3137; -.
DR HOGENOM; CLU_016902_11_4_6; -.
DR OMA; DRHETQF; -.
DR PhylomeDB; Q8ZMD5; -.
DR BioCyc; SENT99287:STM2964-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0009982; F:pseudouridine synthase activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0106029; F:tRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IBA:GO_Central.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; SSF55120; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
PE 3: Inferred from homology;
KW Isomerase; Reference proteome; tRNA processing.
FT CHAIN 1..260
FT /note="tRNA pseudouridine synthase C"
FT /id="PRO_0000162718"
FT ACT_SITE 54
FT /evidence="ECO:0000250"
SQ SEQUENCE 260 AA; 30045 MW; FCB97677E85BA038 CRC64;
MLEILYQDPW LVAVNKPAGW LVHRSWLDRD EKVVVMQTVR DQIGQHVFTA HRLDRPTSGV
LLMGLSSEAG RRLAQQFEQH HIRKRYHAIV RGWLMDDAVL DYPLVEERDK IADKFAREDK
APQPAVTQYR GLATVEMAVP TGRYPTTRYG LVELEPKTGR KHQLRRHLAH LRHPIIGDSK
HGDLRQNRSA AEHFACRRLM LHASRLELTH PFTGQPLIIQ AGLDETWMQA LTQFGWRGLL
PDNERVEFTA ASRQDETHLT
