ID   TRUC_VIBVU              Reviewed;         245 AA.
AC   Q8DBG5;
DT   09-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=tRNA pseudouridine synthase C;
DE            EC=5.4.99.26;
DE   AltName: Full=tRNA pseudouridine(65) synthase;
DE   AltName: Full=tRNA pseudouridylate synthase C;
DE   AltName: Full=tRNA-uridine isomerase C;
GN   Name=truC; OrderedLocusNames=VV1_1855;
OS   Vibrio vulnificus (strain CMCP6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=216895;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CMCP6;
RA   Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.;
RT   "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-65 in
CC       transfer RNAs. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(65) in tRNA = pseudouridine(65) in tRNA;
CC         Xref=Rhea:RHEA:42536, Rhea:RHEA-COMP:10103, Rhea:RHEA-COMP:10104,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.26;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
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DR   EMBL; AE016795; AAO10258.1; -; Genomic_DNA.
DR   RefSeq; WP_011079758.1; NC_004459.3.
DR   AlphaFoldDB; Q8DBG5; -.
DR   SMR; Q8DBG5; -.
DR   EnsemblBacteria; AAO10258; AAO10258; VV1_1855.
DR   KEGG; vvu:VV1_1855; -.
DR   HOGENOM; CLU_016902_11_4_6; -.
DR   OMA; DRHETQF; -.
DR   Proteomes; UP000002275; Chromosome 1.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0106029; F:tRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
PE   3: Inferred from homology;
KW   Isomerase; tRNA processing.
FT   CHAIN           1..245
FT                   /note="tRNA pseudouridine synthase C"
FT                   /id="PRO_0000162722"
FT   ACT_SITE        54
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   245 AA;  28491 MW;  999A96E46E82D145 CRC64;
     MLEIVYQDEY FVAVNKPAGM LVHRSWLDKH ETQFVMQTLR DQIGQHVFPL HRLDRPTSGV
     LVFALSSEVA SQVMPMFAGQ EMSKTYHAIV RGWIEEEGEL DYALKVELDK IADKFASQEK
     EAQDAITLYK PLAKVEVPYS TSKFPTTRYG LMELKPKTGR KHQLRRHMAH LRHPIVGDTT
     HGDGKHNKLF REEFDAPRLL LHASELRFVH PYTQQEVVIR AEVDKVWQQL FERFEWPSTL
     LTASH