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C2D1B_RAT
ID   C2D1B_RAT               Reviewed;         850 AA.
AC   Q5FVK6;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Coiled-coil and C2 domain-containing protein 1B;
DE   AltName: Full=Five prime repressor element under dual repression-binding protein 2;
DE            Short=FRE under dual repression-binding protein 2;
DE            Short=Freud-2;
GN   Name=Cc2d1b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY, AND MASS
RP   SPECTROMETRY.
RC   STRAIN=Holtzman; TISSUE=Sperm;
RX   PubMed=20966424; DOI=10.2164/jandrol.110.010967;
RA   Suryawanshi A.R., Khan S.A., Gajbhiye R.K., Gurav M.Y., Khole V.V.;
RT   "Differential proteomics leads to identification of domain specific
RT   epididymal sperm proteins.";
RL   J. Androl. 32:240-259(2011).
CC   -!- FUNCTION: Transcription factor that binds specifically to the DRE (dual
CC       repressor element) and represses HTR1A gene transcription in neuronal
CC       cells. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5FVK6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5FVK6-2; Sequence=VSP_025664;
CC   -!- TISSUE SPECIFICITY: Expressed in epididymal sperm but not in testicular
CC       sperm (at protein level). {ECO:0000269|PubMed:20966424}.
CC   -!- MASS SPECTROMETRY: Mass=93476.08; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:20966424};
CC   -!- SIMILARITY: Belongs to the CC2D1 family. {ECO:0000305}.
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DR   EMBL; AABR03040177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC089922; AAH89922.1; -; mRNA.
DR   RefSeq; NP_001257913.1; NM_001270984.1. [Q5FVK6-1]
DR   AlphaFoldDB; Q5FVK6; -.
DR   SMR; Q5FVK6; -.
DR   STRING; 10116.ENSRNOP00000011670; -.
DR   iPTMnet; Q5FVK6; -.
DR   PhosphoSitePlus; Q5FVK6; -.
DR   jPOST; Q5FVK6; -.
DR   PaxDb; Q5FVK6; -.
DR   PRIDE; Q5FVK6; -.
DR   Ensembl; ENSRNOT00000011670; ENSRNOP00000011670; ENSRNOG00000008634. [Q5FVK6-1]
DR   GeneID; 313478; -.
DR   KEGG; rno:313478; -.
DR   UCSC; RGD:1306630; rat. [Q5FVK6-1]
DR   CTD; 200014; -.
DR   RGD; 1306630; Cc2d1b.
DR   eggNOG; KOG3837; Eukaryota.
DR   GeneTree; ENSGT00390000009595; -.
DR   HOGENOM; CLU_008808_1_0_1; -.
DR   InParanoid; Q5FVK6; -.
DR   OMA; KMADECM; -.
DR   OrthoDB; 959801at2759; -.
DR   PhylomeDB; Q5FVK6; -.
DR   TreeFam; TF314229; -.
DR   Reactome; R-RNO-9668328; Sealing of the nuclear envelope (NE) by ESCRT-III.
DR   PRO; PR:Q5FVK6; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000008634; Expressed in skeletal muscle tissue and 19 other tissues.
DR   Genevisible; Q5FVK6; RN.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd08690; C2_Freud-1; 1.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR037772; C2_Freud.
DR   InterPro; IPR039725; CC2D1A/B.
DR   InterPro; IPR006608; DM14.
DR   PANTHER; PTHR13076; PTHR13076; 1.
DR   Pfam; PF00168; C2; 1.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00685; DM14; 4.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   PROSITE; PS50004; C2; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..850
FT                   /note="Coiled-coil and C2 domain-containing protein 1B"
FT                   /id="PRO_0000288428"
FT   DOMAIN          668..807
FT                   /note="C2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          54..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          114..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          215..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          436..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          167..213
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        509..525
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         585
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BRN9"
FT   MOD_RES         588
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BRN9"
FT   VAR_SEQ         1..692
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_025664"
SQ   SEQUENCE   850 AA;  93534 MW;  2132241D45424146 CRC64;
     MPGPRPRKGP KTSGQGAETA KQLGLFVEFN PEDMLLGMDE TEDDGDLEAE LLALTGETGS
     TSRKPAPKGR APLPMAHIEK LAADCMRDVE EEGEEEEGLE DDADLLTELQ EVLGVDEETG
     LVDDSEETSP DLSEEKTRDN TEQPVAPAAF QQALPAAVAQ AGGPRGLQAL LEERIQNYRE
     AAASAKEAGE AAKARRCERG LKTLESQLAT VRKGGKICED EIPPPVALGK RPPAHQERPS
     KDSEIDSAGS CAMDPGDLSQ PESSLPAVAA LPDSDPDPQA LLLARQREYK AAALSAKRAG
     DLDRARELMR IGKRFGTVLE ALEKGQPVDL SGMPPAPEDL KALPQASEAS AATQVLSPAV
     EQMQPVMSSD LPATPAAPAE PKTVLDALQQ RLNRYREAGI QARASGDERK ARMHDRIAKQ
     YQDAIRAHQA GRKVDFAELP VPPGFPPIPG LEPRKDTEED SVTATLAAAQ KLASEDTALV
     DEDEERDTPA QAPLAKKPAQ PLVPSSHLLN EPKASSSKES LSPSVREQVT LLEARKLQYQ
     RAALQAKRRQ DLEQAKSHLR VAKSLEAQII QARAGQPIDL SKVPSPLTDE EGDFILIHHE
     DLRLSQKAEE VYAQLQKILL EQHEKCLLFS KQFMHQGNVA ETTRFEKLAE DRKKQLEILQ
     LAQAQGLDPP SHHFELKTLQ TVRIFSELNS TEMHLIIVRG MNLPAPPGVT PDDLDAFVRF
     EFHYPNSDQA QKSKTAVVKN TNSPEFEQVF KLNINRNHRG FRRVIQSKGI KFEIFHKGSF
     FRSDKLVGTA HLKLERLEKE CEIREIMEVL DGRKPTGGKL EVKVRLREPL SSQDVQMVTE
     NWLVLEPRGL
 
 
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