ID   C2D1B_XENLA             Reviewed;         864 AA.
AC   Q6PF54;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Coiled-coil and C2 domain-containing protein 1B;
GN   Name=cc2d1b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the CC2D1 family. {ECO:0000305}.
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DR   EMBL; BC057723; AAH57723.1; -; mRNA.
DR   RefSeq; NP_001079953.1; NM_001086484.1.
DR   RefSeq; XP_018111952.1; XM_018256463.1.
DR   AlphaFoldDB; Q6PF54; -.
DR   SMR; Q6PF54; -.
DR   DNASU; 379644; -.
DR   GeneID; 379644; -.
DR   KEGG; xla:379644; -.
DR   CTD; 379644; -.
DR   Xenbase; XB-GENE-997991; cc2d1b.L.
DR   OMA; KMADECM; -.
DR   OrthoDB; 959801at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 379644; Expressed in zone of skin and 19 other tissues.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd08690; C2_Freud-1; 1.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR037772; C2_Freud.
DR   InterPro; IPR039725; CC2D1A/B.
DR   InterPro; IPR006608; DM14.
DR   PANTHER; PTHR13076; PTHR13076; 1.
DR   Pfam; PF00168; C2; 1.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00685; DM14; 4.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   PROSITE; PS50004; C2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..864
FT                   /note="Coiled-coil and C2 domain-containing protein 1B"
FT                   /id="PRO_0000288429"
FT   DOMAIN          685..820
FT                   /note="C2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   REGION          82..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          441..463
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          478..502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          91..118
FT                   /evidence="ECO:0000255"
FT   COILED          162..209
FT                   /evidence="ECO:0000255"
FT   COILED          385..412
FT                   /evidence="ECO:0000255"
FT   COILED          464..488
FT                   /evidence="ECO:0000255"
FT   COILED          535..564
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        87..123
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..154
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        231..245
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   864 AA;  95681 MW;  6E917F0C7D1B659E CRC64;
     MLGRKLGKKT AQAKGRGAAA AKELGLFVDF SPEDMMLGIP DDPDDGDLEA ELAALTGVKA
     VSKPKPKGKA PLPMEEIEKM AQDCMTDMTG EDDDDDLEED EELLAELQDV VGEEEEVEQS
     QPSDTEESEP SASETQEHTE PEQQVNSSVA EIQHNLQVPA GGMLQVLEER IGNYKEAISN
     AKLSNESAKA RRYERGLKTL ESMLSAARQG RTVIEADIPP PVACGKPAVS PTTDVPTTDT
     SKQGLGDLND VPMETTEAVT NLEKPEDPVS KATTNDGGAV EKTHVASEND TDSKTVLLLR
     QRDYKLAALK AKQTGDIEKA KEYMKISKKF SVVLEALESG QPVDLSNMPA APEDHEAMVT
     ESKIIAHPTP APPVSNILNT QGSSVGSLLQ ALQQRMEKYK SAAQQAKSSG DDRKARMHER
     IAKQYQDTIR AQKAGRQVNL AELPVPPGFP PLPGMEQTEE EGSVEKALEA AQKLAKTAGE
     DVDDDEDECQ AKPPGHPKPT QLVKPLVMPA ISDNEERLLP IKAPVKVASE ETFPPAVQEQ
     LEFLEHRKKQ YRKAALQAKQ KNDLEQAKQH MRVAHTLQVS IDQVKSGKLV DISKVPSLPD
     DEESDFVVVE HEDIKSPQNS EDVYNMLMKL LHEQHEKCIR YSKQFTQMGN VAETTRFENM
     AEDCKKNCEI LQLSQAQGLD PPPYHFEDKT LKIVRVFSEL SSTEMLLIIV RGINLPAPSG
     VAPNDLDAYV KFEFPYPSSE QPQKNKTLVI KNTNSPEYEQ SFKLNINRNH RGFKRVIQTK
     GIKFEIFHKG FFLVRSDKQV GSASVKLDKL ETQCEIREIV EVFDGRKPTG GKLEIKVRLR
     DPLNGQDLQV VTEKWLVMGH VPRK