ID   C2D1_CAEEL              Reviewed;         781 AA.
AC   Q9U2M8;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-DEC-2020, sequence version 3.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Coiled-coil and C2 domain-containing protein 1-like;
GN   ORFNames=Y37H9A.3 {ECO:0000312|WormBase:Y37H9A.3};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SIMILARITY: Belongs to the CC2D1 family. {ECO:0000305}.
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DR   EMBL; BX284601; CAB63350.2; -; Genomic_DNA.
DR   RefSeq; NP_493412.2; NM_061011.2.
DR   AlphaFoldDB; Q9U2M8; -.
DR   SMR; Q9U2M8; -.
DR   BioGRID; 38637; 9.
DR   DIP; DIP-25514N; -.
DR   IntAct; Q9U2M8; 5.
DR   STRING; 6239.Y37H9A.3; -.
DR   iPTMnet; Q9U2M8; -.
DR   EPD; Q9U2M8; -.
DR   PaxDb; Q9U2M8; -.
DR   PeptideAtlas; Q9U2M8; -.
DR   EnsemblMetazoa; Y37H9A.3.1; Y37H9A.3.1; WBGene00012578.
DR   UCSC; Y37H9A.3; c. elegans.
DR   WormBase; Y37H9A.3; CE53023; WBGene00012578; -.
DR   eggNOG; KOG3837; Eukaryota.
DR   GeneTree; ENSGT00390000009595; -.
DR   HOGENOM; CLU_008808_1_0_1; -.
DR   InParanoid; Q9U2M8; -.
DR   OrthoDB; 959801at2759; -.
DR   PhylomeDB; Q9U2M8; -.
DR   Reactome; R-CEL-9668328; Sealing of the nuclear envelope (NE) by ESCRT-III.
DR   PRO; PR:Q9U2M8; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00012578; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd08690; C2_Freud-1; 1.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR037772; C2_Freud.
DR   InterPro; IPR039725; CC2D1A/B.
DR   InterPro; IPR006608; DM14.
DR   PANTHER; PTHR13076; PTHR13076; 1.
DR   Pfam; PF00168; C2; 1.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00685; DM14; 3.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   PROSITE; PS50004; C2; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..781
FT                   /note="Coiled-coil and C2 domain-containing protein 1-like"
FT                   /id="PRO_0000288432"
FT   DOMAIN          605..741
FT                   /note="C2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   REGION          32..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          94..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          187..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          313..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          403..447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..129
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        200..221
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..296
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        322..343
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        359..373
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   781 AA;  84173 MW;  823FA0A13F6EBF29 CRC64;
     MNFNDIDNQM YGNLEEDAEL LAELAAIQEE EMGRVSRPAA PARGAPPAAR GRPAPAAPAN
     VPGLDPRLLA AALADNHGDG GDEELEMDED LLNELNGLVG GGGGGGAAPT VPTRAAPRAP
     GPSGPPPSAS APNSQLGHLK QLHVYYMKAH KSAEQAGEGP KARRYKRAVD KLVELIRAVE
     RGKTIDESEI PVAPPNFSSA AAEPLPPPAP TAQPAHHPPA PPIRQAAHAA ESSPPPIPQR
     KSSAPAPTAA APPATKEPTD PKKAAIYRIL HHRRDLHKQN ARAAIADKDK ESAKESVEMA
     KAFDQAIAAL NECSADEMDM NDVPPSPPPY RKPAPPQPQA PPTSAGPLGF IEELQQRQQR
     FQKMAEKAKT EGNERKMKMN MRLAGQFDEA IKEAKRGKLV NVGELPSLPD MGPLPPQTAP
     GQAAPKLHQR PPPQEVGPLA PSGVEGKSRN QGQLEFLLER QAQFKQAAIH AKSRGDVEAA
     KKYLVEMKGF DKMIQAAQAG LPVSIKATPI PPQAQTASTT LQPRIQSAAA SSSTGVENRG
     EKLSLLEKTL IEQVRSAETN QMRFTRLGDV GKVRLFEGWG KVAKQDLLLV REVAKRGLQV
     PKFHYEMRQI PSADLFPDLA DDVIELTIVS CRDVPLPSGY ETHHANLFIK YTFPAVVNDL
     PQTGKTKLIA GTASPDFGES IMLNIGSGKS RNSKLQRTFK RGGLKFEVFQ KGGFMRSDKL
     LGTCEWKLEK LEHSAEMEES LPLKDGRKAV GGLLSAKVRI RQPIGDAKAQ HIAQKWLILD
     N