ID   C2D1_DROPS              Reviewed;         814 AA.
AC   Q29M42;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Coiled-coil and C2 domain-containing protein 1-like;
GN   ORFNames=GA18377;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- SIMILARITY: Belongs to the CC2D1 family. {ECO:0000305}.
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DR   EMBL; CH379060; EAL33853.2; -; Genomic_DNA.
DR   RefSeq; XP_001356787.2; XM_001356751.3.
DR   AlphaFoldDB; Q29M42; -.
DR   SMR; Q29M42; -.
DR   STRING; 7237.FBpp0280670; -.
DR   PRIDE; Q29M42; -.
DR   EnsemblMetazoa; FBtr0282232; FBpp0280670; FBgn0078380.
DR   GeneID; 4817348; -.
DR   KEGG; dpo:Dpse_GA18377; -.
DR   eggNOG; KOG3837; Eukaryota.
DR   HOGENOM; CLU_008808_1_0_1; -.
DR   InParanoid; Q29M42; -.
DR   OMA; NLAKQHY; -.
DR   Proteomes; UP000001819; Chromosome 4.
DR   Bgee; FBgn0078380; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd08690; C2_Freud-1; 1.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR037772; C2_Freud.
DR   InterPro; IPR039725; CC2D1A/B.
DR   InterPro; IPR006608; DM14.
DR   PANTHER; PTHR13076; PTHR13076; 1.
DR   Pfam; PF00168; C2; 1.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00685; DM14; 4.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   PROSITE; PS50004; C2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..814
FT                   /note="Coiled-coil and C2 domain-containing protein 1-like"
FT                   /id="PRO_0000288431"
FT   DOMAIN          633..772
FT                   /note="C2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   REGION          1..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          157..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          414..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          349..380
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        31..45
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        224..253
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        414..439
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        440..464
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        472..486
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   814 AA;  88594 MW;  EA4594132408D217 CRC64;
     MFAKRKPEPA KRRQHNLAQF GLTEIPDDFD PTSGYGDDDG GDSDLEAELA ALASGGGQRP
     KAKPKPKLMP TSDLDKMIAD SLRDVSDDDD DENLENDSDL LGELHGIGGL EEEPEAEEAA
     AEPAASEEEP VQTFLPTTTV DTLGIIKQRL EIYKQAEANA KASGDSGKAR RFGRGLKTLQ
     DLHKQAAAGK TINVDDIPPE VSVKPAGDPS PAADESPAPS TPVSQPTRVA PAPPTPTSPP
     AATPPPAPAT PPNPLVAQMR SRQSEYKAAA LQYKRSGDTA NALQFLKVVK QFDVVVKMCE
     DGQEVDLSDM PPPPSEFLEF LAKMKGEAAP EVVTAPEPTP APAPATPPAA AAAAESMLEA
     LQRRLEKYKS VEAAAKAEEN TGKARRFGRI VKQYEDAIKQ YKAGKPVAYD ELPVPPGFGP
     LPSTEPAPAA TPSLPTSPTS PPATASTSAG GTPSGSSATT PTVPRKAAPS PPQPTELTTR
     VTGNHQKSNL AEQQMKLLLE RQKEFKVAAI EAKKAGEIDQ AKEYLKIYKG FDSLLNAASS
     GLPVDLSTLP VPPSQRDNLE ASFAIVSAEE CDPSDDICEI GVRMEEQLAK QLMMCKNTRD
     HHKAMGDVAG MNRFENLALT VQKDLDVVRY SKRKGQPLPK FHYEKRNFNI VHCNTDLTDN
     ELEIVVARGI NYNVPNPKEV DTYVRVEFPL LNDESFKTKT NVIKDTNSPD YDERFKVDIQ
     RSNRQFQRIF KRHGVKLEIY SRGGFLRSDI LIGTVNVKLQ PLETKCDIHD TYDLMDGRKQ
     VGGKLEVKVR VRNPILTKQI EHINEKWLVL DAEG