C2GR1_ARATH
ID C2GR1_ARATH Reviewed; 1020 AA.
AC Q9ZVT9; Q7EAV1;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 4.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=C2 and GRAM domain-containing protein At1g03370;
GN OrderedLocusNames=At1g03370; ORFNames=F15K9.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP INDUCTION.
RX PubMed=18201690; DOI=10.1016/j.ydbio.2007.11.031;
RA Jiang S.Y., Ramamoorthy R., Ramachandran S.;
RT "Comparative transcriptional profiling and evolutionary analysis of the
RT GRAM domain family in eukaryotes.";
RL Dev. Biol. 314:418-432(2008).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU00041};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Up-regulated by Cold. Down-regulated by salt.
CC {ECO:0000269|PubMed:18201690}.
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DR EMBL; AC005278; AAC72128.2; -; Genomic_DNA.
DR EMBL; CP002684; AEE27565.1; -; Genomic_DNA.
DR EMBL; AY120771; AAM53329.1; -; mRNA.
DR PIR; E86165; E86165.
DR RefSeq; NP_171836.3; NM_100219.5.
DR AlphaFoldDB; Q9ZVT9; -.
DR SMR; Q9ZVT9; -.
DR STRING; 3702.AT1G03370.1; -.
DR iPTMnet; Q9ZVT9; -.
DR PaxDb; Q9ZVT9; -.
DR PRIDE; Q9ZVT9; -.
DR ProteomicsDB; 240257; -.
DR EnsemblPlants; AT1G03370.1; AT1G03370.1; AT1G03370.
DR GeneID; 839519; -.
DR Gramene; AT1G03370.1; AT1G03370.1; AT1G03370.
DR KEGG; ath:AT1G03370; -.
DR Araport; AT1G03370; -.
DR TAIR; locus:2014510; AT1G03370.
DR eggNOG; KOG1032; Eukaryota.
DR HOGENOM; CLU_009431_0_0_1; -.
DR InParanoid; Q9ZVT9; -.
DR OMA; PSVMKIN; -.
DR OrthoDB; 106336at2759; -.
DR PRO; PR:Q9ZVT9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9ZVT9; baseline and differential.
DR Genevisible; Q9ZVT9; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.30.29.30; -; 1.
DR Gene3D; 2.60.40.150; -; 2.
DR InterPro; IPR044511; At1g03370/At5g50170-like.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR031968; VASt.
DR PANTHER; PTHR46296; PTHR46296; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF16016; VASt; 2.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00239; C2; 2.
DR SMART; SM00568; GRAM; 1.
DR SUPFAM; SSF49562; SSF49562; 2.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51778; VAST; 2.
PE 2: Evidence at transcript level;
KW Calcium; Membrane; Metal-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1020
FT /note="C2 and GRAM domain-containing protein At1g03370"
FT /id="PRO_0000395979"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1..102
FT /note="C2 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 249..421
FT /note="VASt 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01114"
FT DOMAIN 517..635
FT /note="C2 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 689..752
FT /note="GRAM"
FT DOMAIN 848..1010
FT /note="VASt 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01114"
FT REGION 134..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 17
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 17
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 23
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 69
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 69
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 71
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 71
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 77
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 551
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 557
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 604
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 605
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 606
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
SQ SEQUENCE 1020 AA; 114205 MW; 53B3EA54E6C522A4 CRC64;
MKLQVRVVEA RNLPAMDLNG FSDPYVRLQL GKQRSRTKVV KKNLNPKWTE DFSFGVDDLN
DELVVSVLDE DKYFNDDFVG QVRVSVSLVF DAENQSLGTV WYPLNPKKKG SKKDCGEILL
KICFSQKNSV LDLTSSGDQT SASRSPDLRL ESPIDPSTCA SPSRSDDASS IPQTTFAGRF
TQIFQKNAIT ATPTQSSSRS IDASDLSEIS KPVFSLELSE DESSSTSFEE LLKAMESKDQ
GSEPPSNLSG GVVVDQLFMI SPSDLNIVLF ASDSSFYASL TELQGTTEVQ IGPWKAENDG
ESVKRVVSYL KAATKLIKAV KGTEEQTYLK ADGEVYAVLA SVATPDVPFG GTFKVEVLYC
ISPGPELPSG EQCSRLVVSW RLNFLQSTMM RGMIENGARQ GLKDNFEQYA NLLAQSVKPV
DSKDIGLNKE QALSSLQAEP QSDWKLAVQY FANFTVLSTF LIGIYVFVHI VFAIPSAIQG
LEFNGLDLPD SIGEFVVSGV LVLQCERVLQ LISRFMQARK QKGSDHGIKA HGDGWLLTVA
LIEGVDLAAV DPSGHCDPYI VFTSNGKTRT SSIKFQKSNP QWNEIFEFDA MADPPSVLNV
EVFDFDGPFD EAVSLGHAEV NFVRSNISDL ADVWVPLQGK LAQACQSKLH LRIFLDHTGG
GDVVRDYLNK MEKEVGKKIN VRSPQTNSAF QKLFGLPQEE FLINDFTCHL KRKMPLQGRL
FLSARIVGFY ASIFGNKTKF FFLWEDIEEI QVLPPTLASM GSPIVVMTLR PNRGLDARIG
AKTHDEEGRL KFHFHSFVSF NVAQKTIMAL WKAKSLTPEQ KVQAVEEESE QKLQSEESGL
FLGVDDVRFS EVFSLTLPVP VSFFMELFGG GEVDRKAMER AGCQSYSCSP WESEKDDVYE
RQTYYRDKRI SRYRGEVTST QQKSLVPEKN GWLVEEVMTL HGVPLGDYFN LHLRYQMEES
TSKPKTTYVR VYFGIEWLKS TRHQKRVTKN ILVNLQDRLK MTFGFLEKEY SSRQQQQQVT
