C2GR2_ARATH
ID C2GR2_ARATH Reviewed; 1027 AA.
AC Q9FGS8;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=C2 and GRAM domain-containing protein At5g50170;
GN OrderedLocusNames=At5g50170; ORFNames=K6A12_3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AB024031; BAB09388.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95906.1; -; Genomic_DNA.
DR EMBL; AY056116; AAL07002.1; -; mRNA.
DR EMBL; BT009696; AAP88330.1; -; mRNA.
DR RefSeq; NP_199828.1; NM_124396.3.
DR AlphaFoldDB; Q9FGS8; -.
DR SMR; Q9FGS8; -.
DR STRING; 3702.AT5G50170.1; -.
DR PaxDb; Q9FGS8; -.
DR PRIDE; Q9FGS8; -.
DR ProteomicsDB; 240516; -.
DR EnsemblPlants; AT5G50170.1; AT5G50170.1; AT5G50170.
DR GeneID; 835082; -.
DR Gramene; AT5G50170.1; AT5G50170.1; AT5G50170.
DR KEGG; ath:AT5G50170; -.
DR Araport; AT5G50170; -.
DR TAIR; locus:2157707; AT5G50170.
DR eggNOG; KOG1032; Eukaryota.
DR HOGENOM; CLU_009431_0_0_1; -.
DR InParanoid; Q9FGS8; -.
DR OMA; EQQSDWE; -.
DR OrthoDB; 106336at2759; -.
DR PhylomeDB; Q9FGS8; -.
DR PRO; PR:Q9FGS8; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FGS8; baseline and differential.
DR Genevisible; Q9FGS8; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.30.29.30; -; 1.
DR Gene3D; 2.60.40.150; -; 2.
DR InterPro; IPR044511; At1g03370/At5g50170-like.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR031968; VASt.
DR PANTHER; PTHR46296; PTHR46296; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF16016; VASt; 2.
DR SMART; SM00239; C2; 2.
DR SMART; SM00568; GRAM; 1.
DR SUPFAM; SSF49562; SSF49562; 2.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51778; VAST; 2.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..1027
FT /note="C2 and GRAM domain-containing protein At5g50170"
FT /id="PRO_0000395980"
FT TRANSMEM 452..472
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1..103
FT /note="C2 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 253..426
FT /note="VASt 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01114"
FT DOMAIN 516..639
FT /note="C2 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 693..756
FT /note="GRAM"
FT DOMAIN 855..1018
FT /note="VASt 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01114"
FT REGION 158..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1027 AA; 115859 MW; 55F5A9AA9B15B17C CRC64;
MRLYVYILQA KDLPAKETFA KLHVGRHKSK TRVARDTSSP IWNEEFVFRI SDVDEGDDVV
VSILHHEQQD HQSIVSTGLI GKVRIPLTSV AAEENQTLLP TWFVIEKPSD GKFVNIECGK
ILLSLSLQGK WESTSGEKVL NDKQDIINLE GVKELEGSPK DLISSRDGKR RKHHDGKHIM
KNIVNHIDKL FHKKEEISKR LHDESSVGQS VNSNYEDATD QCSSSATCTG FEEGLDLMQS
SDSEREEMPE NLTGGVLVDQ KYLVSPCELN KFLFTPSSQF RKELAELQGL SDVQEGPWTM
MQEDTPRLTR VVTYMRAATK MVKAVKATEN QVYRKASGKQ FAVFVSVSTP DVPYGNTFKI
ELLYKILPET EPTAGGEASR LIISWGIQFS QSTIMKGMIE GGARQGLKES FEQFSNLLAK
TYKTLDPAVV LDKEQVIATV QSEPKTDLKS AFLYFWSSSV ICAVLLSVYV VVHMLHCEPS
KIQGFEFYGL DLPDSFGELF SSGILVLLLE RVYIMTVHFV QARLHRGRDQ GVKANGKGWI
LTIALIKGTN LASVEATELF DPYVVFTCNG KTRTSSVKLQ AQDPQWNEVI EFDAMEEPPS
VLDVEVFDFD GPFDQGASLG HAEINFLKHT ADELADLSVA LVGNHAQASQ SKLQLRIFLE
NKNGVETMKD YLSKVEKEVG KKLNIRSPQK NSAFQKLFGL PHEEFLLKEY TCYLKRKLPV
QGKLFLSARI VAFYSNVFGH KTKFYFLWED IDDIQVLPPT FASLGSPLLL IILKKNRGLD
AKHGAKSQDD EGRLSFYFQS FVSFDATSRT IMALWKTRTL SVDHRAQIVE EDQDVADPFL
LPEAVTVVSD ADALMMSKVY TCDLPCDVEL VMKIFGGGEL ERKIMEKSGC LSYASTTWES
KKPGVYERRL SYKYNHYVSV FGGGVTCAQQ KSPAPNDEGW ILNEIVALHD VPFGDHFRVH
IRYEVKKAGV DCKTSKCEVY LKIRWLKTIK FEQRISKSIM EKFRNRFKVI FDLFQKESVA
NSSLTLL
