TRUNK_DROME
ID TRUNK_DROME Reviewed; 226 AA.
AC Q24155; Q9VL09;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Protein trunk;
DE Flags: Precursor;
GN Name=trk; ORFNames=CG5619;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7590233; DOI=10.1101/gad.9.20.2539;
RA Casanova J., Furriols M., McCormick C.A., Struhl G.;
RT "Similarities between trunk and spatzle, putative extracellular ligands
RT specifying body pattern in Drosophila.";
RL Genes Dev. 9:2539-2544(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Required for activity of the tor receptor, could be a ligand
CC of tor. Involved in specifying terminal body pattern.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the noggin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF52896.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U41064; AAC46953.1; -; Genomic_DNA.
DR EMBL; AE014134; AAF52896.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_476767.2; NM_057419.3.
DR AlphaFoldDB; Q24155; -.
DR BioGRID; 60463; 8.
DR STRING; 7227.FBpp0079667; -.
DR PaxDb; Q24155; -.
DR EnsemblMetazoa; FBtr0080078; FBpp0079667; FBgn0003751.
DR GeneID; 34376; -.
DR KEGG; dme:Dmel_CG5619; -.
DR UCSC; CG5619-RA; d. melanogaster.
DR CTD; 34376; -.
DR FlyBase; FBgn0003751; trk.
DR VEuPathDB; VectorBase:FBgn0003751; -.
DR eggNOG; ENOG502SBEB; Eukaryota.
DR HOGENOM; CLU_1103538_0_0_1; -.
DR InParanoid; Q24155; -.
DR OrthoDB; 1391421at2759; -.
DR PhylomeDB; Q24155; -.
DR BioGRID-ORCS; 34376; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 34376; -.
DR PRO; PR:Q24155; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0003751; Expressed in egg chamber and 10 other tissues.
DR Genevisible; Q24155; DM.
DR GO; GO:0005615; C:extracellular space; IDA:FlyBase.
DR GO; GO:0048018; F:receptor ligand activity; IDA:FlyBase.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0005122; F:torso binding; IDA:FlyBase.
DR GO; GO:0007362; P:terminal region determination; IDA:FlyBase.
DR GO; GO:0008293; P:torso signaling pathway; IDA:FlyBase.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR SUPFAM; SSF57501; SSF57501; 1.
PE 3: Inferred from homology;
KW Developmental protein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..226
FT /note="Protein trunk"
FT /id="PRO_0000022589"
SQ SEQUENCE 226 AA; 26348 MW; 2CF1B5049C63521B CRC64;
MKSQSELAIV LTWLAVLGTA QDDADYCAEL STQSLAKILG QAFNPRYMSI DPPGEPEEKS
YHLGYKRSSY ELPFYADSDA ISVSHFPAWE TNHFALVEKK KEAPRSKSLR TRSAFMDRVG
HPRIDGFKQR PWECSSKINW IDLGLNYFPR YIRSIECIAR KCWYDHFNCK PKSFTIKVLR
RKTGSCIRIN DKLILITAEK FENDYTQLWI WEEIAVNFCC ECVMLY
