ID   TRX1_ALHV1              Reviewed;         334 AA.
AC   O36412;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   23-FEB-2022, entry version 54.
DE   RecName: Full=Triplex capsid protein 1 {ECO:0000255|HAMAP-Rule:MF_04018};
GN   Name=TRX1 {ECO:0000255|HAMAP-Rule:MF_04018}; OrderedLocusNames=62;
OS   Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Macavirus.
OX   NCBI_TaxID=654901;
OH   NCBI_TaxID=9927; Connochaetes taurinus (Blue wildebeest).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9261371; DOI=10.1128/jvi.71.9.6517-6525.1997;
RA   Ensser A., Pflanz R., Fleckenstein B.;
RT   "Primary structure of the alcelaphine herpesvirus 1 genome.";
RL   J. Virol. 71:6517-6525(1997).
CC   -!- FUNCTION: Structural component of the T=16 icosahedral capsid. The
CC       capsid is composed of pentamers and hexamers of major capsid
CC       protein/MCP, which are linked together by heterotrimers called
CC       triplexes. These triplexes are formed by a single molecule of triplex
CC       protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally,
CC       TRX1 is required for efficient transport of TRX2 to the nucleus, which
CC       is the site of capsid assembly. {ECO:0000255|HAMAP-Rule:MF_04018}.
CC   -!- SUBUNIT: Interacts with TRX2, MCP and capsid vertex component 2/CVC2.
CC       {ECO:0000255|HAMAP-Rule:MF_04018}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04018}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04018}.
CC   -!- SIMILARITY: Belongs to the herpesviridae TRX1 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04018}.
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DR   EMBL; AF005370; AAC58109.1; -; Genomic_DNA.
DR   PIR; T03157; T03157.
DR   RefSeq; NP_065561.1; NC_002531.1.
DR   SMR; O36412; -.
DR   GeneID; 911786; -.
DR   KEGG; vg:911786; -.
DR   Proteomes; UP000000941; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019069; P:viral capsid assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04018; HSV_TRX1; 1.
DR   InterPro; IPR004999; Herpes_1.
DR   Pfam; PF03327; Herpes_VP19C; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Reference proteome; Virion.
FT   CHAIN           1..334
FT                   /note="Triplex capsid protein 1"
FT                   /id="PRO_0000405763"
SQ   SEQUENCE   334 AA;  37001 MW;  70A8076BB8700D77 CRC64;
     MKTKQDPRDQ KNYDSLQSNL FRLIPPTTHK ISLARPNGFL RGLADLVGKY SVDGAEESLF
     QPGAWDAPYV QPAFFDFLVH AKTISKHEPV GVPLFCFKNN STAPSIDVLF TPISFHAAVG
     LPADVDPNVH RVAHIWYGDD SEVSSLMEDL NILLEESNLH TRLHPVGILV ENNDSSFLNR
     VTALTHGPAY MSRKQAALKL VIPTDLFVDL DARLNVEAYG AQPSGGTSTV FCTLVYTRCG
     NDIKPALTFF KSNKSDFDVL TLIRAYYADL ITNKLEVNQQ CNINGLKFGV MCTVGYTDSS
     HSINQQSLCI RGSSLLVTSI SNFFVNYTGW RVFA