ID   TRX1_EHV2               Reviewed;         338 AA.
AC   Q66664;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-DEC-2020, entry version 51.
DE   RecName: Full=Triplex capsid protein 1 {ECO:0000255|HAMAP-Rule:MF_04018};
GN   Name=TRX1 {ECO:0000255|HAMAP-Rule:MF_04018}; OrderedLocusNames=62;
OS   Equine herpesvirus 2 (strain 86/87) (EHV-2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Percavirus.
OX   NCBI_TaxID=82831;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7783207; DOI=10.1006/jmbi.1995.0314;
RA   Telford E.A.R., Watson M.S., Aird H.C., Perry J., Davison A.J.;
RT   "The DNA sequence of equine herpesvirus 2.";
RL   J. Mol. Biol. 249:520-528(1995).
CC   -!- FUNCTION: Structural component of the T=16 icosahedral capsid. The
CC       capsid is composed of pentamers and hexamers of major capsid
CC       protein/MCP, which are linked together by heterotrimers called
CC       triplexes. These triplexes are formed by a single molecule of triplex
CC       protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally,
CC       TRX1 is required for efficient transport of TRX2 to the nucleus, which
CC       is the site of capsid assembly. {ECO:0000255|HAMAP-Rule:MF_04018}.
CC   -!- SUBUNIT: Interacts with TRX2, MCP and capsid vertex component 2/CVC2.
CC       {ECO:0000255|HAMAP-Rule:MF_04018}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04018}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04018}.
CC   -!- SIMILARITY: Belongs to the herpesviridae TRX1 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04018}.
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DR   EMBL; U20824; AAC13850.1; -; Genomic_DNA.
DR   PIR; S55657; S55657.
DR   RefSeq; NP_042659.1; NC_001650.2.
DR   SMR; Q66664; -.
DR   GeneID; 1461038; -.
DR   KEGG; vg:1461038; -.
DR   Proteomes; UP000007083; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019069; P:viral capsid assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04018; HSV_TRX1; 1.
DR   InterPro; IPR004999; Herpes_1.
DR   Pfam; PF03327; Herpes_VP19C; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Reference proteome; Virion.
FT   CHAIN           1..338
FT                   /note="Triplex capsid protein 1"
FT                   /id="PRO_0000406042"
SQ   SEQUENCE   338 AA;  37509 MW;  C6E87A8C369B742F CRC64;
     MKTKEVTPRG DSGEKLARDL LRLVPPQTHK LGTFRASELG RDLRAIVANY APKTISGHIQ
     IFRDDFIAPP YRQPLYGEFL VHAKTFHPQE PRGTFVFAFS VGDGPECTSV DTIFSPVSLF
     RVCGLGADAA PHTHRISHIW YESESDFLNV AANVRELIEN CSLHKFLSPV GPLVQNIQST
     FLNKITTVVK GEVLSNRSPP ENIKLVLPSD LFFDMDETCP YPPSGDPVKP RVCYYVCILY
     VMVNNIPSAS LQFFRTGKGA SDVVFFLRRY YSDAIANKIT VLGDNLDINN LTLGAVCMLG
     YSSSQSTPGR GNLHFRSYSL PTVEVSDFVA QPGSWTLI