ID   TRX1_GAHVM              Reviewed;         470 AA.
AC   Q9E6N1;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   23-FEB-2022, entry version 59.
DE   RecName: Full=Triplex capsid protein 1 {ECO:0000255|HAMAP-Rule:MF_04018};
GN   Name=TRX1 {ECO:0000255|HAMAP-Rule:MF_04018}; OrderedLocusNames=MDV051;
OS   Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's
OS   disease herpesvirus type 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10389;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10933706; DOI=10.1128/jvi.74.17.7980-7988.2000;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.;
RT   "The genome of a very virulent Marek's disease virus.";
RL   J. Virol. 74:7980-7988(2000).
CC   -!- FUNCTION: Structural component of the T=16 icosahedral capsid. The
CC       capsid is composed of pentamers and hexamers of major capsid
CC       protein/MCP, which are linked together by heterotrimers called
CC       triplexes. These triplexes are formed by a single molecule of triplex
CC       protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally,
CC       TRX1 is required for efficient transport of TRX2 to the nucleus, which
CC       is the site of capsid assembly. {ECO:0000255|HAMAP-Rule:MF_04018}.
CC   -!- SUBUNIT: Interacts with TRX2, MCP and capsid vertex component 2/CVC2.
CC       {ECO:0000255|HAMAP-Rule:MF_04018}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04018}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04018}.
CC   -!- SIMILARITY: Belongs to the herpesviridae TRX1 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04018}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF243438; AAG14231.1; -; Genomic_DNA.
DR   RefSeq; YP_001033967.1; NC_002229.3.
DR   SMR; Q9E6N1; -.
DR   GeneID; 4811512; -.
DR   KEGG; vg:4811512; -.
DR   Proteomes; UP000008072; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019069; P:viral capsid assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04018; HSV_TRX1; 1.
DR   InterPro; IPR004999; Herpes_1.
DR   Pfam; PF03327; Herpes_VP19C; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Reference proteome; Virion.
FT   CHAIN           1..470
FT                   /note="Triplex capsid protein 1"
FT                   /id="PRO_0000406515"
SQ   SEQUENCE   470 AA;  52856 MW;  6FC3FD3613F87DD4 CRC64;
     MKPLLRSHET QYYSLYPDTL NGLHNVFRTI GNSVQSDTVR RLNLGYLDGD NRRGNLAGGL
     ELLRDATTPN ASRMNITRPL DTSTSGATAM IMQSLRTDVA ENITLLTGDS RATISRQVTL
     TDFCFPDAEM PGLIILSIRH PLDINSEALY ATPAGRDPRV METVWYELSE LAAVSVNRVN
     GSGVRPSLVS LSFLIAARAS DYADKCGAEA LRAHVISNYG RRRMEEKLDR FGICLITMLR
     CRVFPHRHFQ LLGGLISWIS QREIASITAV VRGPQESIKT EQTAMPRSSV YVPACAYIDF
     DKDIRVIHEE RSSSSLYLVF VYTQKFGRET VRIYVMRSRL GEWAFREGLG YMYSGVRSNN
     AITGVDGLIV PHGANVNMEF PLTKTLDLRN RDRRLGIAAR SRDLNKADWK VDLRGRPTKE
     SCMYAAYCRL GHLDESSVPV KKFERCGSLD IPVIWIPGVI WNIGTWIECY