ID   TRX1_HHV7J              Reviewed;         286 AA.
AC   P52349;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   02-DEC-2020, entry version 64.
DE   RecName: Full=Triplex capsid protein 1 {ECO:0000255|HAMAP-Rule:MF_04018};
GN   Name=TRX1 {ECO:0000255|HAMAP-Rule:MF_04018}; OrderedLocusNames=U29;
OS   Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=57278;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8709220; DOI=10.1128/jvi.70.9.5975-5989.1996;
RA   Nicholas J.;
RT   "Determination and analysis of the complete nucleotide sequence of human
RT   herpesvirus.";
RL   J. Virol. 70:5975-5989(1996).
CC   -!- FUNCTION: Structural component of the T=16 icosahedral capsid. The
CC       capsid is composed of pentamers and hexamers of major capsid
CC       protein/MCP, which are linked together by heterotrimers called
CC       triplexes. These triplexes are formed by a single molecule of triplex
CC       protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally,
CC       TRX1 is required for efficient transport of TRX2 to the nucleus, which
CC       is the site of capsid assembly. {ECO:0000255|HAMAP-Rule:MF_04018}.
CC   -!- SUBUNIT: Interacts with TRX2, MCP and capsid vertex component 2/CVC2.
CC       {ECO:0000255|HAMAP-Rule:MF_04018}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04018}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04018}.
CC   -!- SIMILARITY: Belongs to the herpesviridae TRX1 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04018}.
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DR   EMBL; U43400; AAC54691.1; -; Genomic_DNA.
DR   PIR; T41931; T41931.
DR   SMR; P52349; -.
DR   Proteomes; UP000009246; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019069; P:viral capsid assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04018; HSV_TRX1; 1.
DR   InterPro; IPR004999; Herpes_1.
DR   Pfam; PF03327; Herpes_VP19C; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Reference proteome; Virion.
FT   CHAIN           1..286
FT                   /note="Triplex capsid protein 1"
FT                   /id="PRO_0000115720"
SQ   SEQUENCE   286 AA;  33112 MW;  FD7219FF883D6725 CRC64;
     MEMLQKRKHQ TIDETSLNNL IENEKKKIKS LLAFGVPKEC VLSRSFTPCE LLGPERDHLG
     MLMFRLETDA ESPKFLLISV LFLAMNAFNV SFCTRTSLAN LYKTSLVDSI NTMLDSCSYL
     EEKVSLFGVT NYISQGTNCL ISCVMQGHVY DVRKENIYGL VILKDLLLEP DWEPRQNAIQ
     YIYLCYIYRQ AFNKIEYGIY IVLSELTHEE VLIDLLRNKF SKERFMFMNY LINGDGNLNY
     FGSLQRIGHC KTQNIKSGIL DLQGISLTII RLKDVFVELC ERKIFL