ID   TRX1_HHV8P              Reviewed;         331 AA.
AC   F5H8Y5;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 31.
DE   RecName: Full=Triplex capsid protein 1 {ECO:0000255|HAMAP-Rule:MF_04018};
GN   Name=TRX1 {ECO:0000255|HAMAP-Rule:MF_04018}; OrderedLocusNames=ORF62;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
CC   -!- FUNCTION: Structural component of the T=16 icosahedral capsid. The
CC       capsid is composed of pentamers and hexamers of major capsid
CC       protein/MCP, which are linked together by heterotrimers called
CC       triplexes. These triplexes are formed by a single molecule of triplex
CC       protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally,
CC       TRX1 is required for efficient transport of TRX2 to the nucleus, which
CC       is the site of capsid assembly. {ECO:0000255|HAMAP-Rule:MF_04018}.
CC   -!- SUBUNIT: Interacts with TRX2, MCP and capsid vertex component 2/CVC2.
CC       {ECO:0000255|HAMAP-Rule:MF_04018}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04018}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04018}.
CC   -!- SIMILARITY: Belongs to the herpesviridae TRX1 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04018}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF148805; ABD28917.1; -; Genomic_DNA.
DR   RefSeq; YP_001129419.1; NC_009333.1.
DR   PDB; 6PPB; EM; 4.30 A; 5/b=1-331.
DR   PDB; 6PPD; EM; 3.70 A; 5/b=1-331.
DR   PDB; 6PPH; EM; 3.80 A; 5/b=1-331.
DR   PDBsum; 6PPB; -.
DR   PDBsum; 6PPD; -.
DR   PDBsum; 6PPH; -.
DR   SMR; F5H8Y5; -.
DR   BioGRID; 1776964; 2.
DR   DNASU; 4961461; -.
DR   GeneID; 4961461; -.
DR   KEGG; vg:4961461; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019069; P:viral capsid assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04018; HSV_TRX1; 1.
DR   InterPro; IPR004999; Herpes_1.
DR   Pfam; PF03327; Herpes_VP19C; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Capsid protein; Host nucleus; Reference proteome; Virion.
FT   CHAIN           1..331
FT                   /note="Triplex capsid protein 1"
FT                   /id="PRO_0000423769"
SQ   SEQUENCE   331 AA;  36336 MW;  91113380F7C0B7FB CRC64;
     MKVQAENAAR LGRQVLGLLP PPTHRVSLTR GPEFARGVRD LLSKYAASTR PTVGSLHEAL
     RQAPFRQPTY GDFLVYSQTF SPQEPLGTFL FSFKQEDNGS SMDMLLTPTS LFMLSGMEAA
     KAPQTHKVAG VWYGSGSGLA DFIPNLSELM DTGEFHTLLT PVGPMVQSVH STFVTKVTSA
     MKGVGLARDE PRAHVGLTLP CDMLVDLDES CPMVQRREPA GLNVTIYASL VYLRVNQRPS
     MALTFFQSGK GFAEVVAMIK DHFTDVIRTK YIQLRHELYI NRLVFGAVCT LGTVPFDSHP
     VHQSLNVKGT SLPVLVFANF EAACGPWTVF L