ID   C2_CONVX                Reviewed;          68 AA.
AC   Q8I6R2;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Conotoxin Vx2;
DE   Flags: Precursor;
OS   Conus vexillum (Flag cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Rhizoconus.
OX   NCBI_TaxID=89431;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 48-48, SYNTHESIS OF 48-48,
RP   AND MASS SPECTROMETRY.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=16181706; DOI=10.1016/j.peptides.2005.08.004;
RA   Jiang H., Wang C.-Z., Xu C.-Q., Fan C.-X., Dai X.-D., Chen J.-S.,
RA   Chi C.-W.;
RT   "A novel M-superfamily conotoxin with a unique motif from Conus vexillum.";
RL   Peptides 27:682-689(2006).
CC   -!- FUNCTION: Elicits a series of symptoms, such as being sedative, tail
CC       stiffening and twisted jumping, when injected intracranially into mice.
CC       May not target potassium nor sodium channels of locust DUM neuron.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is II (CCC-C-C-C).
CC   -!- MASS SPECTROMETRY: Mass=2243.70; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:16181706};
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   EMBL; AY161317; AAN78279.1; -; mRNA.
DR   AlphaFoldDB; Q8I6R2; -.
DR   ConoServer; 823; VxII precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Neurotoxin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..47
FT                   /evidence="ECO:0000269|PubMed:16181706"
FT                   /id="PRO_0000249803"
FT   PEPTIDE         48..68
FT                   /note="Conotoxin Vx2"
FT                   /id="PRO_0000249804"
FT   DISULFID        55..68
FT                   /evidence="ECO:0000250"
FT   DISULFID        56..61
FT                   /evidence="ECO:0000250"
FT   DISULFID        57..65
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   68 AA;  7244 MW;  0B61EEB2AAD38FD8 CRC64;
     MMSKLGVLVT ICLLLFPLTA LPLDGDQPAD HPAKRTQDHN LASPISAWID PSHYCCCGGG
     CTDDCVNC