ID   C2_CWPXG                Reviewed;         512 AA.
AC   P87617;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   23-FEB-2022, entry version 75.
DE   RecName: Full=Kelch repeat protein C2;
GN   ORFNames=C18L;
OS   Cowpox virus (strain GRI-90 / Grishak) (CPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=265871;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9785; Loxodonta africana (African elephant).
OH   NCBI_TaxID=29092; Microtus agrestis (Short-tailed field vole).
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
OH   NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Shchelkunov S.N., Safronov P.F., Totmenin A.V., Miheev M.V.,
RA   Ryazankina O.I., Petrov N.A., Gutorov V.V., Kotwal G.J., Sandakhchiev L.S.;
RT   "Structure-function and organization of cowpox virus strain GRI-90 complete
RT   genome.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the poxviruses Kelch family. {ECO:0000305}.
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DR   EMBL; X94355; CAA64103.1; -; Genomic_DNA.
DR   SMR; P87617; -.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 3.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 3.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   3: Inferred from homology;
KW   Kelch repeat; Repeat.
FT   CHAIN           1..512
FT                   /note="Kelch repeat protein C2"
FT                   /id="PRO_0000119162"
FT   DOMAIN          2..67
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          102..176
FT                   /note="BACK"
FT   REPEAT          216..261
FT                   /note="Kelch 1"
FT   REPEAT          262..307
FT                   /note="Kelch 2"
FT   REPEAT          309..354
FT                   /note="Kelch 3"
FT   REPEAT          356..403
FT                   /note="Kelch 4"
FT   REPEAT          405..449
FT                   /note="Kelch 5"
FT   REPEAT          452..498
FT                   /note="Kelch 6"
SQ   SEQUENCE   512 AA;  59231 MW;  6A79C196EDA5A99B CRC64;
     MESVIFSING EIIQVNKEII TASPYNFFKR IQDHHLKDEA IILNGINYHA FESLLDYMRW
     KKINITINNV EMILVAAIII DVPPVVDLCV KTMIHNINST NCIRMFNFSK RYGIKKLYNA
     SMSEIINNIT AVTSDPEFGK LSKDELTTIL SHEDVNVNHE DVTAMILLKW IHKNPNDVDI
     INILHPKFMT NTMRNAISLL GLTISKSTKP VTRNGIKHNI VVIKNSDYIS TITHYSPRTE
     YWTIVGNTDR QFYNANVLHN CLYIIGGMIN NRHVYSVSRV DLKTKKWKTV TNMSSLKSEV
     STCVNDGKLY VIGGLEFSIS TGVAEYLKHG TSKWIRLPNL ITPRYSGASV FVNDDIYVMG
     GVYTTYEKYV VLNDVECFTK NRWIKKSPMP RHHSIVYAVE YDGDIYAITG ITHETRNYLY
     KYIVKEDKWI ELYMYFNHVG KMFVCSCGDY ILIIADAKYE YYPKSNTWNL FDMSTRNIEY
     YDMFTKDETP KCNVTHKSLP SFLSNCEKQF LQ