ID   TRX2_HHV7J              Reviewed;         293 AA.
AC   P68321; P52350;
DT   09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   09-NOV-2004, sequence version 1.
DT   02-JUN-2021, entry version 58.
DE   RecName: Full=Triplex capsid protein 2 {ECO:0000255|HAMAP-Rule:MF_04019};
GN   Name=TRX2 {ECO:0000255|HAMAP-Rule:MF_04019}; OrderedLocusNames=U56;
OS   Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=57278;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8709220; DOI=10.1128/jvi.70.9.5975-5989.1996;
RA   Nicholas J.;
RT   "Determination and analysis of the complete nucleotide sequence of human
RT   herpesvirus.";
RL   J. Virol. 70:5975-5989(1996).
CC   -!- FUNCTION: Structural component of the T=16 icosahedral capsid. The
CC       capsid is composed of pentamers and hexamers of major capsid
CC       protein/MCP, which are linked together by heterotrimers called
CC       triplexes. These triplexes are formed by a single molecule of triplex
CC       protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally,
CC       TRX1 is required for efficient transport of TRX2 to the nucleus, which
CC       is the site of capsid assembly. {ECO:0000255|HAMAP-Rule:MF_04019}.
CC   -!- SUBUNIT: Interacts with TRX1 and major capisd protein/MCP.
CC       {ECO:0000255|HAMAP-Rule:MF_04019}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04019}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04019}.
CC   -!- SIMILARITY: Belongs to the herpesviridae TRX2 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04019}.
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DR   EMBL; U43400; AAC54719.1; -; Genomic_DNA.
DR   PIR; T41959; T41959.
DR   RefSeq; YP_073798.1; NC_001716.2.
DR   SMR; P68321; -.
DR   PRIDE; P68321; -.
DR   DNASU; 3289516; -.
DR   GeneID; 3289516; -.
DR   KEGG; vg:3289516; -.
DR   Proteomes; UP000009246; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0019069; P:viral capsid assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04019; HSV_TRX2; 1.
DR   InterPro; IPR002690; Herpes_capsid_2.
DR   Pfam; PF01802; Herpes_V23; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Reference proteome; Virion.
FT   CHAIN           1..293
FT                   /note="Triplex capsid protein 2"
FT                   /id="PRO_0000115728"
SQ   SEQUENCE   293 AA;  33338 MW;  8B72A6D2FC2AF67E CRC64;
     MDSIYCTFDQ KLTLSDIGTL CKLTNAVIPI PSHRHLIGNT NLGLYTVLST TTDYIQIRDI
     LKTMVLTILQ KVEGNQLILI RPKIGHQYEI KNTGPFPLEK GDQLSLLPPF LKPSQQLLVL
     PNWELILPLL IPTDVATEIN VRMLCISLLS IHRKYEEVQI IIDELRTLQY RDVTIKLPDV
     INDCKSTFSM KTACISFSMI ATMAPDIVQT YIERLSLEDQ SMLLIKCQEL LAKKNFSQEP
     SSFKATEIKT ELQKIKTVFT MINQINSLTQ EKTFFIVADV SADNRLATCI FKE