TRX2_HHV7M
ID TRX2_HHV7M Reviewed; 293 AA.
AC P68322; P52350;
DT 09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 09-NOV-2004, sequence version 1.
DT 02-JUN-2021, entry version 38.
DE RecName: Full=Triplex capsid protein 2 {ECO:0000255|HAMAP-Rule:MF_04019};
GN Name=TRX2 {ECO:0000255|HAMAP-Rule:MF_04019}; OrderedLocusNames=U56;
OS Human herpesvirus 7 (strain MUK) (HHV-7) (Human T lymphotropic virus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX NCBI_TaxID=57279;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Mukai T., Isegawa Y., Yamanishi K.;
RL Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Structural component of the T=16 icosahedral capsid. The
CC capsid is composed of pentamers and hexamers of major capsid
CC protein/MCP, which are linked together by heterotrimers called
CC triplexes. These triplexes are formed by a single molecule of triplex
CC protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally,
CC TRX1 is required for efficient transport of TRX2 to the nucleus, which
CC is the site of capsid assembly. {ECO:0000255|HAMAP-Rule:MF_04019}.
CC -!- SUBUNIT: Interacts with TRX1 and major capisd protein/MCP.
CC {ECO:0000255|HAMAP-Rule:MF_04019}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04019}. Host
CC nucleus {ECO:0000255|HAMAP-Rule:MF_04019}.
CC -!- SIMILARITY: Belongs to the herpesviridae TRX2 protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04019}.
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DR EMBL; D32005; BAA06771.1; -; Genomic_DNA.
DR RefSeq; YP_073798.1; NC_001716.2.
DR SMR; P68322; -.
DR DNASU; 3289516; -.
DR GeneID; 3289516; -.
DR KEGG; vg:3289516; -.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0019069; P:viral capsid assembly; IEA:UniProtKB-UniRule.
DR HAMAP; MF_04019; HSV_TRX2; 1.
DR InterPro; IPR002690; Herpes_capsid_2.
DR Pfam; PF01802; Herpes_V23; 1.
PE 3: Inferred from homology;
KW Capsid protein; Host nucleus; Virion.
FT CHAIN 1..293
FT /note="Triplex capsid protein 2"
FT /id="PRO_0000115729"
SQ SEQUENCE 293 AA; 33338 MW; 8B72A6D2FC2AF67E CRC64;
MDSIYCTFDQ KLTLSDIGTL CKLTNAVIPI PSHRHLIGNT NLGLYTVLST TTDYIQIRDI
LKTMVLTILQ KVEGNQLILI RPKIGHQYEI KNTGPFPLEK GDQLSLLPPF LKPSQQLLVL
PNWELILPLL IPTDVATEIN VRMLCISLLS IHRKYEEVQI IIDELRTLQY RDVTIKLPDV
INDCKSTFSM KTACISFSMI ATMAPDIVQT YIERLSLEDQ SMLLIKCQEL LAKKNFSQEP
SSFKATEIKT ELQKIKTVFT MINQINSLTQ EKTFFIVADV SADNRLATCI FKE