ID   C2_TPCTV                Reviewed;         159 AA.
AC   Q88889;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   29-SEP-2021, entry version 53.
DE   RecName: Full=Protein C2;
DE   AltName: Full=Protein L2;
GN   ORFNames=C2, L2;
OS   Tomato pseudo-curly top virus (TPCTV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Repensiviricetes;
OC   Geplafuvirales; Geminiviridae; Topocuvirus.
OX   NCBI_TaxID=49267;
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OH   NCBI_TaxID=4112; Solanum nigrum (Black nightshade).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8638404; DOI=10.1006/viro.1996.0264;
RA   Briddon R.W., Bedford I.D., Tsai J.H., Markham P.G.;
RT   "Analysis of the nucleotide sequence of the treehopper-transmitted
RT   geminivirus, tomato pseudo-curly top virus, suggests a recombinant
RT   origin.";
RL   Virology 219:387-394(1996).
CC   -!- FUNCTION: Acts as a suppressor of RNA-mediated gene silencing, also
CC       known as post-transcriptional gene silencing (PTGS), a mechanism of
CC       plant viral defense that limits the accumulation of viral RNAs.
CC       Suppresses the host RNA silencing by inhibiting adenosine kinase 2
CC       (ADK2), a kinase involved in a general methylation pathway. Also
CC       suppresses the host basal defense by interacting with and inhibiting
CC       SNF1 kinase, a key regulator of cell metabolism implicated in innate
CC       antiviral defense. Determines pathogenicity (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Suppress local silencing by interacting with and
CC       inactivating host adenosine kinase 2 (ADK2) in the cytoplasm. Interacts
CC       with and inhibits host SNF1 kinase (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The zinc finger is involved in PTGS suppression. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the geminiviridae transcriptional activator
CC       protein family. {ECO:0000305}.
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DR   EMBL; X84735; CAA59224.1; -; Genomic_DNA.
DR   RefSeq; NP_620734.1; NC_003825.1.
DR   GeneID; 944405; -.
DR   KEGG; vg:944405; -.
DR   Proteomes; UP000007068; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR000942; Gemini_AL2.
DR   Pfam; PF01440; Gemini_AL2; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction; Metal-binding; Reference proteome;
KW   Suppressor of RNA silencing; Zinc; Zinc-finger.
FT   CHAIN           1..159
FT                   /note="Protein C2"
FT                   /id="PRO_0000323706"
FT   ZN_FING         65..81
FT                   /evidence="ECO:0000250"
FT   REGION          102..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           43..60
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        112..133
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   159 AA;  17950 MW;  DC0380A2D53ABAD1 CRC64;
     MVLCDKGAHE LGNREIRKGF CERCLYPEYF DDEEAATTTP TIKKRPPKLT WAPKKKRRKA
     IHLSCGCSYY GGIDCEDGFT HRGITHVHTV PDWLLLRRHQ EPNLLPPPEH NNNGDGEQNN
     NITNQSQPQP AESVGSPDLL AELGGTFSIT SSEWRSIIR