ID   C2_VACCW                Reviewed;         512 AA.
AC   P17371; Q76ZY3;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   23-FEB-2022, entry version 93.
DE   RecName: Full=Kelch repeat protein C2;
GN   OrderedLocusNames=VACWR026; ORFNames=C2L;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2849238; DOI=10.1016/s0042-6822(88)90115-8;
RA   Kotwal G.J., Moss B.;
RT   "Analysis of a large cluster of nonessential genes deleted from a vaccinia
RT   virus terminal transposition mutant.";
RL   Virology 167:524-537(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the poxviruses Kelch family. {ECO:0000305}.
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DR   EMBL; M22812; AAA69606.1; -; Genomic_DNA.
DR   EMBL; AY243312; AAO89305.1; -; Genomic_DNA.
DR   PIR; F33348; WZVZB6.
DR   RefSeq; YP_232908.1; NC_006998.1.
DR   SMR; P17371; -.
DR   DNASU; 3707641; -.
DR   GeneID; 3707641; -.
DR   KEGG; vg:3707641; -.
DR   Proteomes; UP000000344; Genome.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 3.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 3.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   3: Inferred from homology;
KW   Early protein; Kelch repeat; Reference proteome; Repeat.
FT   CHAIN           1..512
FT                   /note="Kelch repeat protein C2"
FT                   /id="PRO_0000119159"
FT   DOMAIN          2..67
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          102..176
FT                   /note="BACK"
FT   REPEAT          216..261
FT                   /note="Kelch 1"
FT   REPEAT          262..307
FT                   /note="Kelch 2"
FT   REPEAT          309..354
FT                   /note="Kelch 3"
FT   REPEAT          356..403
FT                   /note="Kelch 4"
FT   REPEAT          405..449
FT                   /note="Kelch 5"
FT   REPEAT          452..498
FT                   /note="Kelch 6"
SQ   SEQUENCE   512 AA;  59241 MW;  14F9A2FFB8520A83 CRC64;
     MESVIFSING EIIQVNKEII TASPYNFFKR IQDHHLKDEA IILNGINYHA FESLLDYIRW
     KKINITINNV EMILVAAIII DVPPVVDLCV KTMIHNINST NCIRMFNFSK RYGIKKLYNA
     SMSEIINNIT AVTSDPEFGK LSKDELTTIL SHENVNVNHE DVTAMILLKW IHKNPNDVDI
     INILHPKFMT NTMRNAISLL GLTISKSTKP VTRNGIKHNI VVIKNSDYIS TITHYSPRTE
     YWTIVGNTDR QFYNANVLHN CLYIIGGMIN NRHVYSVSRV DLETKKWKTV TNMSSLKSEV
     STCVNDGKLY VIGGLEFSIS TGVAEYLKHG TSKWIRLPNL ITPRYSGASV FVNDDIYVMG
     GVYTTYEKYV VLNDVECFTK NRWIKKSPMP RHHSIVYAVE YDGDIYVITG ITHETRNYLY
     KYIVKEDKWI ELYMYFNHVG KMFVCSCGDY ILIIADAKYE YYPKSNTWNL FDMSTRNIEY
     YDMFTKDETP KCNVTHKSLP SFLSNCEKQF LQ