C30_CONCL
ID C30_CONCL Reviewed; 82 AA.
AC P0DTX8;
DT 07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT 07-OCT-2020, sequence version 1.
DT 25-MAY-2022, entry version 4.
DE RecName: Full=Conotoxin Cal30 {ECO:0000305};
DE AltName: Full=O2_cal30 {ECO:0000303|PubMed:30791616};
DE Flags: Precursor;
OS Californiconus californicus (California cone) (Conus californicus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX NCBI_TaxID=1736779;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=30791616; DOI=10.3390/toxins11020128;
RA Bernaldez-Sarabia J., Figueroa-Montiel A., Duenas S., Cervantes-Luevano K.,
RA Beltran J.A., Ortiz E., Jimenez S., Possani L.D., Paniagua-Solis J.F.,
RA Gonzalez-Canudas J., Licea-Navarro A.;
RT "The diversified O-superfamily in Californiconus californicus presents a
RT conotoxin with antimycobacterial activity.";
RL Toxins 11:1-13(2019).
CC -!- FUNCTION: Probable neurotoxin. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:30791616}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:30791616}.
CC -!- DOMAIN: The cysteine framework is XXX (C-C-CCC-C-C-C-CC).
CC {ECO:0000305}.
CC -!- PTM: May contain 5 disulfide bonds. {ECO:0000305}.
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DR AlphaFoldDB; P0DTX8; -.
DR SMR; P0DTX8; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR015812; Integrin_bsu.
PE 3: Inferred from homology;
KW Disulfide bond; Neurotoxin; Secreted; Signal; Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..82
FT /note="Conotoxin Cal30"
FT /evidence="ECO:0000305"
FT /id="PRO_0000450960"
SQ SEQUENCE 82 AA; 8914 MW; F0C1A741E983A57D CRC64;
MEKLIILLLV ASLLVTTDSV VKGKKAARGW LFNEVETCEL GGLGDPCSGS GDCCCDQCLC
SGSYEHCTQN PDRWFCCRTY GN