ID   C340_ORYLA              Reviewed;         502 AA.
AC   Q98T91;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Cytochrome P450 3A40;
DE            EC=1.14.14.1;
GN   Name=cyp3a40;
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11139226;
RX   DOI=10.1002/1098-2795(200102)58:2<149::aid-mrd3>3.0.co;2-x;
RA   Kullman S.W., Hinton D.E.;
RT   "Identification, characterization, and ontogeny of a second cytochrome P450
RT   3A gene from the fresh water teleost medaka (Oryzias latipes).";
RL   Mol. Reprod. Dev. 58:149-158(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein
CC         reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein
CC         reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-
CC         COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210,
CC         ChEBI:CHEBI:142491; EC=1.14.14.1;
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC       Peripheral membrane protein {ECO:0000305}. Microsome membrane
CC       {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AF251272; AAK37960.1; -; mRNA.
DR   RefSeq; NP_001098565.1; NM_001105095.1.
DR   AlphaFoldDB; Q98T91; -.
DR   SMR; Q98T91; -.
DR   STRING; 8090.ENSORLP00000024339; -.
DR   PRIDE; Q98T91; -.
DR   GeneID; 100125817; -.
DR   KEGG; ola:100125817; -.
DR   CTD; 100125817; -.
DR   eggNOG; KOG0158; Eukaryota.
DR   InParanoid; Q98T91; -.
DR   OrthoDB; 467733at2759; -.
DR   Proteomes; UP000001038; Unplaced.
DR   Proteomes; UP000265180; Chromosome 9.
DR   Proteomes; UP000265200; Chromosome 9.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR008072; Cyt_P450_E_CYP3A.
DR   InterPro; IPR002402; Cyt_P450_E_grp-II.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00464; EP450II.
DR   PRINTS; PR01689; EP450IICYP3A.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW   Monooxygenase; Oxidoreductase; Reference proteome.
FT   CHAIN           1..502
FT                   /note="Cytochrome P450 3A40"
FT                   /id="PRO_0000051812"
FT   BINDING         443
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   502 AA;  57707 MW;  1E9FE38B21CED1D8 CRC64;
     MGNFLYFSAE TWTLLVAFIT LLLVYAYWPY GTFKRLGIPG PKPVPFFGTM LAYRKGFFNF
     DDECRKKYGK TWGIYDGRQP VLCITDPATI KAVLVKECYS LFTNRRNFRL NGPLYDAVSI
     AEDDQWKRIR SVLSPSFTSG RLKEMFDIMK HHSANLIQSM KKKVDKDEPL EMKEYFGPYS
     MDVVTSTAFS VDIDSLNNPS DPFVTNIKKM LKFDFLNPLF LAVAFFPFLG PILEKFEFSL
     FPSSVMDFFF AALRKIKANH ENNKQKSRID FLQLMIDSQK NNQNGLQDKG LSDHEILSQA
     MIFIFAGYET TSSSLTFLAY NLATNPEVMK KLQKEIDATF PNKAPVQYVP LMEMEYLDCV
     VNESLRLYPI AARLERVAKA TVEVNGLVIP KDMVVMVPTW PLHRDPELWP EPEKFKPERF
     SKENKDTFDP YTYMPFGAGP RNCIGMRFAL VMMKLAVVEI LQTYDFSVCK ETEVPFEMDV
     QGFLAPKRPI QLKLTPRSAS SS