TRXX_ARATH
ID TRXX_ARATH Reviewed; 182 AA.
AC Q8LD49; Q9SEU5; Q9SX49;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 2.
DT 25-MAY-2022, entry version 135.
DE RecName: Full=Thioredoxin X, chloroplastic;
DE Short=AtTrxx;
DE Flags: Precursor;
GN Name=ATHX; Synonyms=ATHP; OrderedLocusNames=At1g50320; ORFNames=F14I3.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 6-182, AND TISSUE SPECIFICITY.
RX PubMed=10580150; DOI=10.1016/s0378-1119(99)00448-5;
RA Mestres-Ortega D., Meyer Y.;
RT "The Arabidopsis thaliana genome encodes at least four thioredoxins m and a
RT new prokaryotic-like thioredoxin.";
RL Gene 240:307-316(1999).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19825616; DOI=10.1093/mp/ssn076;
RA Chibani K., Wingsle G., Jacquot J.P., Gelhaye E., Rouhier N.;
RT "Comparative genomic study of the thioredoxin family in photosynthetic
RT organisms with emphasis on Populus trichocarpa.";
RL Mol. Plant 2:308-322(2009).
RN [7]
RP SUBCELLULAR LOCATION.
RX PubMed=19259774; DOI=10.1007/s11103-009-9471-4;
RA Cain P., Hall M., Schroder W.P., Kieselbach T., Robinson C.;
RT "A novel extended family of stromal thioredoxins.";
RL Plant Mol. Biol. 70:273-281(2009).
CC -!- FUNCTION: Probable thiol-disulfide oxidoreductase that may participate
CC in various redox reactions.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast stroma
CC {ECO:0000269|PubMed:19259774}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in leaves.
CC {ECO:0000269|PubMed:10580150}.
CC -!- SIMILARITY: Belongs to the thioredoxin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF15952.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC007980; AAD50039.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32536.1; -; Genomic_DNA.
DR EMBL; AF324698; AAG40049.1; -; mRNA.
DR EMBL; AF326860; AAG41442.1; -; mRNA.
DR EMBL; AF339683; AAK00365.1; -; mRNA.
DR EMBL; AF386924; AAK62369.1; -; mRNA.
DR EMBL; BT000355; AAN15674.1; -; mRNA.
DR EMBL; AY086205; AAM64283.1; -; mRNA.
DR EMBL; AF095753; AAF15952.1; ALT_INIT; mRNA.
DR PIR; E96539; E96539.
DR RefSeq; NP_564566.1; NM_103916.3.
DR AlphaFoldDB; Q8LD49; -.
DR SMR; Q8LD49; -.
DR BioGRID; 26679; 4.
DR IntAct; Q8LD49; 2.
DR MINT; Q8LD49; -.
DR STRING; 3702.AT1G50320.1; -.
DR PaxDb; Q8LD49; -.
DR PRIDE; Q8LD49; -.
DR ProteomicsDB; 234647; -.
DR EnsemblPlants; AT1G50320.1; AT1G50320.1; AT1G50320.
DR GeneID; 841454; -.
DR Gramene; AT1G50320.1; AT1G50320.1; AT1G50320.
DR KEGG; ath:AT1G50320; -.
DR Araport; AT1G50320; -.
DR TAIR; locus:2011932; AT1G50320.
DR eggNOG; KOG0910; Eukaryota.
DR HOGENOM; CLU_090389_0_3_1; -.
DR InParanoid; Q8LD49; -.
DR OMA; VANAIRC; -.
DR OrthoDB; 1482186at2759; -.
DR PhylomeDB; Q8LD49; -.
DR PRO; PR:Q8LD49; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8LD49; baseline and differential.
DR Genevisible; Q8LD49; AT.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0009570; C:chloroplast stroma; IDA:TAIR.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0008047; F:enzyme activator activity; IDA:TAIR.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0016671; F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; IBA:GO_Central.
DR GO; GO:0043085; P:positive regulation of catalytic activity; IDA:TAIR.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 2: Evidence at transcript level;
KW Chloroplast; Disulfide bond; Electron transport; Plastid;
KW Redox-active center; Reference proteome; Transit peptide; Transport.
FT TRANSIT 1..67
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 68..182
FT /note="Thioredoxin X, chloroplastic"
FT /id="PRO_0000034166"
FT DOMAIN 68..177
FT /note="Thioredoxin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT ACT_SITE 99
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT ACT_SITE 102
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT SITE 100
FT /note="Contributes to redox potential value"
FT /evidence="ECO:0000250"
FT SITE 101
FT /note="Contributes to redox potential value"
FT /evidence="ECO:0000250"
FT DISULFID 99..102
FT /note="Redox-active"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT CONFLICT 117
FT /note="Missing (in Ref. 4; AAM64283)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 182 AA; 19648 MW; 30DB7A499A0B28D3 CRC64;
MDSIVSSSTI LMRSYLTPPV RSCSPATSVS VKPLSSVQVT SVAANRHLLS LSSGARRTRK
SSSSVIRCGG IKEIGESEFS STVLESAQPV LVEFVATWCG PCKLIYPAME ALSQEYGDKL
TIVKIDHDAN PKLIAEFKVY GLPHFILFKD GKEVPGSRRE GAITKAKLKE YIDGLLNSIS
VA
