TRY1_BOVIN
ID TRY1_BOVIN Reviewed; 246 AA.
AC P00760; A6H6Y3;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 3.
DT 03-AUG-2022, entry version 221.
DE RecName: Full=Serine protease 1 {ECO:0000250|UniProtKB:P07477};
DE EC=3.4.21.4;
DE AltName: Full=Anionic trypsin I {ECO:0000250|UniProtKB:P00762};
DE AltName: Full=Anionic trypsin-I {ECO:0000250|UniProtKB:P00762};
DE AltName: Full=Beta-trypsin;
DE AltName: Full=Cationic trypsin;
DE AltName: Full=Pretrypsinogen I {ECO:0000250|UniProtKB:P00762};
DE AltName: Full=Trypsin I {ECO:0000250|UniProtKB:P07477};
DE AltName: Full=Trypsin-I;
DE Contains:
DE RecName: Full=Alpha-trypsin chain 1;
DE Contains:
DE RecName: Full=Alpha-trypsin chain 2;
DE Flags: Precursor;
GN Name=PRSS1; Synonyms=TRP1, TRY1 {ECO:0000250|UniProtKB:P07477}, TRYP1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal pancreas;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 4-246.
RC TISSUE=Pancreas;
RA Okajima T., Maniwa M., Nagao S., Fujikawa H., Goto S.;
RL Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PROTEIN SEQUENCE OF 18-246, AND DISULFIDE BONDS.
RX PubMed=5967094; DOI=10.1016/0006-291x(66)90162-8;
RA Mikes O., Holeysovsky V., Tomasek V., Sorm F.;
RT "Covalent structure of bovine trypsinogen. The position of the remaining
RT amides.";
RL Biochem. Biophys. Res. Commun. 24:346-352(1966).
RN [4]
RP SEQUENCE REVISION.
RX PubMed=4399051; DOI=10.1098/rstb.1970.0010;
RA Hartley B.S.;
RT "Homologies in serine proteinases.";
RL Philos. Trans. R. Soc. Lond., B, Biol. Sci. 257:77-87(1970).
RN [5]
RP SEQUENCE REVISION.
RX PubMed=1092332; DOI=10.1021/bi00678a003;
RA Titani K., Ericsson L.H., Neurath H., Walsh K.A.;
RT "Amino acid sequence of dogfish trypsin.";
RL Biochemistry 14:1358-1366(1975).
RN [6]
RP ABSENCE OF SULFATED TYROSINE.
RX PubMed=17087724; DOI=10.1111/j.1742-4658.2006.05501.x;
RA Sahin-Toth M., Kukor Z., Nemoda Z.;
RT "Human cationic trypsinogen is sulfated on Tyr154.";
RL FEBS J. 273:5044-5050(2006).
RN [7]
RP DISULFIDE BONDS.
RX PubMed=5892911; DOI=10.1016/s0022-2836(65)80340-0;
RA Kauffman D.L.;
RT "The disulphide bridges of trypsin.";
RL J. Mol. Biol. 12:929-932(1965).
RN [8]
RP INTERACTION WITH HUMAN SERPINA1.
RX PubMed=11057674; DOI=10.1038/35038119;
RA Huntington J.A., Read R.J., Carrell R.W.;
RT "Structure of a serpin-protease complex shows inhibition by deformation.";
RL Nature 407:923-926(2000).
RN [9]
RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF CALCIUM-BINDING SITE.
RX PubMed=512; DOI=10.1016/s0022-2836(75)80005-2;
RA Bode W., Schwager P.;
RT "The refined crystal structure of bovine beta-trypsin at 1.8-A resolution.
RT II. Crystallographic refinement, calcium binding site, benzamidine binding
RT site and active site at pH 7.0.";
RL J. Mol. Biol. 98:693-717(1975).
RN [10]
RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
RX PubMed=556951; DOI=10.1021/bi00623a016;
RA Kossiakoff A.A., Chambers J.L., Kay L.M., Stroud R.M.;
RT "Structure of bovine trypsinogen at 1.9-A resolution.";
RL Biochemistry 16:654-664(1977).
RN [11]
RP X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) OF 24-246 IN COMPLEX WITH
RP V.HEDERIFOLIA TRYPSIN INHIBITOR, AND DISULFIDE BONDS.
RX PubMed=17640870; DOI=10.1074/jbc.m703871200;
RA Conners R., Konarev A.V., Forsyth J., Lovegrove A., Marsh J.,
RA Joseph-Horne T., Shewry P., Brady R.L.;
RT "An unusual helix-turn-helix protease inhibitory motif in a novel trypsin
RT inhibitor from seeds of Veronica (Veronica hederifolia L.).";
RL J. Biol. Chem. 282:27760-27768(2007).
RN [12]
RP X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS) OF 24-246 IN COMPLEX WITH THE SNAKE
RP VENOM PROTEASE INHIBITOR TEXTILININ-1, DISULFIDE BONDS, AND METAL-BINDING
RP SITES GLU-75; ASN-77; VAL-80 AND GLU-85.
RX PubMed=23335990; DOI=10.1371/journal.pone.0054104;
RA Millers E.K., Johnson L.A., Birrell G.W., Masci P.P., Lavin M.F.,
RA de Jersey J., Guddat L.W.;
RT "The structure of human microplasmin in complex with textilinin-1, an
RT aprotinin-like inhibitor from the Australian brown snake.";
RL PLoS ONE 8:E54104-E54104(2013).
RN [13] {ECO:0000312|PDB:6MRQ}
RP X-RAY CRYSTALLOGRAPHY (1.29 ANGSTROMS) IN COMPLEX WITH VENOM SCORPION
RP CYCLOTIDE TRYPSIN INHIBITOR TOPI1, ACTIVITY REGULATION, AND DISULFIDE
RP BONDS.
RC TISSUE=Telson;
RX PubMed=32787139; DOI=10.1021/acs.jmedchem.0c00686;
RA Mourao C.B.F., Brand G.D., Fernandes J.P.C., Prates M.V., Bloch C. Jr.,
RA Barbosa J.A.R.G., Freitas S.M., Restano-Cassulini R., Possani L.D.,
RA Schwartz E.F.;
RT "Head-to-Tail Cyclization after Interaction with Trypsin: A Scorpion Venom
RT Peptide that Resembles Plant Cyclotides.";
RL J. Med. Chem. 63:9500-9511(2020).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.4;
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Note=Binds 1 Ca(2+) ion per subunit.;
CC -!- ACTIVITY REGULATION: Is inhibited by scorpion cyclotide trypsin
CC inhibitor TopI1. {ECO:0000269|PubMed:32787139}.
CC -!- SUBUNIT: Interacts with SERPINA1. {ECO:0000269|PubMed:11057674}.
CC -!- INTERACTION:
CC P00760; P00974; NbExp=4; IntAct=EBI-986385, EBI-1032263;
CC P00760; P01009: SERPINA1; Xeno; NbExp=5; IntAct=EBI-986385, EBI-986224;
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC -!- TISSUE SPECIFICITY: Synthesized in the acinar cells of the pancreas.
CC -!- PTM: Autocatalytic cleavage after Lys-23 leads to beta-trypsin by
CC releasing a terminal hexapeptide. Subsequent cleavage after Lys-148
CC leads to alpha-trypsin. Further cleavage after Lys-193 yields
CC pseudotrypsin. A cleavage may also occur after Arg-122.
CC -!- PTM: Not sulfated on tyrosine residue(s).
CC -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00274}.
CC -!- WEB RESOURCE: Name=Worthington enzyme manual;
CC URL="https://www.worthington-biochem.com/TRY/";
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DR EMBL; BC134797; AAI34798.1; -; mRNA.
DR EMBL; BC146041; AAI46042.1; -; mRNA.
DR EMBL; D38507; BAA07516.1; -; mRNA.
DR PIR; A90164; TRBOTR.
DR RefSeq; NP_001107199.1; NM_001113727.1.
DR RefSeq; XP_002687054.3; XM_002687008.5.
DR RefSeq; XP_871686.4; XM_866593.7.
DR PDB; 1AQ7; X-ray; 2.20 A; A=24-246.
DR PDB; 1AUJ; X-ray; 2.10 A; A=24-246.
DR PDB; 1AZ8; X-ray; 1.80 A; A=24-246.
DR PDB; 1BJU; X-ray; 1.80 A; A=24-246.
DR PDB; 1BJV; X-ray; 1.80 A; A=24-246.
DR PDB; 1BTP; X-ray; 2.20 A; A=18-246.
DR PDB; 1BTW; X-ray; 1.70 A; A=18-246.
DR PDB; 1BTX; X-ray; 1.70 A; A=18-246.
DR PDB; 1BTY; X-ray; 1.50 A; A=18-246.
DR PDB; 1BTZ; X-ray; 2.00 A; A=18-246.
DR PDB; 1C1N; X-ray; 1.40 A; A=24-246.
DR PDB; 1C1O; X-ray; 1.40 A; A=24-246.
DR PDB; 1C1P; X-ray; 1.37 A; A=24-246.
DR PDB; 1C1Q; X-ray; 1.37 A; A=24-246.
DR PDB; 1C1R; X-ray; 1.37 A; A=24-246.
DR PDB; 1C1S; X-ray; 1.63 A; A=24-246.
DR PDB; 1C1T; X-ray; 1.37 A; A=24-246.
DR PDB; 1C2D; X-ray; 1.65 A; A=24-246.
DR PDB; 1C2E; X-ray; 1.65 A; A=24-246.
DR PDB; 1C2F; X-ray; 1.70 A; A=24-246.
DR PDB; 1C2G; X-ray; 1.65 A; A=24-246.
DR PDB; 1C2H; X-ray; 1.40 A; A=24-246.
DR PDB; 1C2I; X-ray; 1.47 A; A=24-246.
DR PDB; 1C2J; X-ray; 1.40 A; A=24-246.
DR PDB; 1C2K; X-ray; 1.65 A; A=24-246.
DR PDB; 1C2L; X-ray; 1.50 A; A=24-246.
DR PDB; 1C2M; X-ray; 1.40 A; A=24-246.
DR PDB; 1C5P; X-ray; 1.43 A; A=24-246.
DR PDB; 1C5Q; X-ray; 1.43 A; A=24-246.
DR PDB; 1C5R; X-ray; 1.47 A; A=24-246.
DR PDB; 1C5S; X-ray; 1.36 A; A=24-246.
DR PDB; 1C5T; X-ray; 1.37 A; A=24-246.
DR PDB; 1C5U; X-ray; 1.37 A; A=24-246.
DR PDB; 1C5V; X-ray; 1.48 A; A=24-246.
DR PDB; 1C9T; X-ray; 3.30 A; A/B/C/D/E/F=24-246.
DR PDB; 1CE5; X-ray; 1.90 A; A=24-246.
DR PDB; 1D6R; X-ray; 2.30 A; A=24-246.
DR PDB; 1EB2; X-ray; 2.00 A; A=24-246.
DR PDB; 1EJM; X-ray; 1.85 A; A/C/E=24-246.
DR PDB; 1EZX; X-ray; 2.60 A; C=4-246.
DR PDB; 1F0T; X-ray; 1.80 A; A=4-246.
DR PDB; 1F0U; X-ray; 1.90 A; A=4-246.
DR PDB; 1F2S; X-ray; 1.79 A; E=24-246.
DR PDB; 1G36; X-ray; 1.90 A; A=24-246.
DR PDB; 1G3B; X-ray; 1.80 A; A=19-246.
DR PDB; 1G3C; X-ray; 1.80 A; A=19-246.
DR PDB; 1G3D; X-ray; 1.80 A; A=19-246.
DR PDB; 1G3E; X-ray; 1.80 A; A=19-246.
DR PDB; 1G9I; X-ray; 2.20 A; E=24-246.
DR PDB; 1GBT; X-ray; 2.00 A; A=24-246.
DR PDB; 1GHZ; X-ray; 1.39 A; A=24-246.
DR PDB; 1GI0; X-ray; 1.42 A; A=24-246.
DR PDB; 1GI1; X-ray; 1.42 A; A=24-246.
DR PDB; 1GI2; X-ray; 1.38 A; A=24-246.
DR PDB; 1GI3; X-ray; 1.44 A; A=24-246.
DR PDB; 1GI4; X-ray; 1.37 A; A=24-246.
DR PDB; 1GI5; X-ray; 1.60 A; A=24-246.
DR PDB; 1GI6; X-ray; 1.49 A; A=24-246.
DR PDB; 1GJ6; X-ray; 1.50 A; A=24-246.
DR PDB; 1HJ9; X-ray; 0.95 A; A=24-246.
DR PDB; 1J8A; X-ray; 1.21 A; A=24-246.
DR PDB; 1JIR; X-ray; 2.00 A; A=24-246.
DR PDB; 1JRS; X-ray; 1.80 A; A=24-246.
DR PDB; 1JRT; X-ray; 1.70 A; A=24-246.
DR PDB; 1K1I; X-ray; 2.20 A; A=24-246.
DR PDB; 1K1J; X-ray; 2.20 A; A=24-246.
DR PDB; 1K1L; X-ray; 2.50 A; A=24-246.
DR PDB; 1K1M; X-ray; 2.20 A; A=24-246.
DR PDB; 1K1N; X-ray; 2.00 A; A=24-246.
DR PDB; 1K1O; X-ray; 2.00 A; A=24-246.
DR PDB; 1K1P; X-ray; 1.90 A; A=24-246.
DR PDB; 1LQE; X-ray; 2.20 A; A=4-246.
DR PDB; 1MAX; X-ray; 1.80 A; A=24-246.
DR PDB; 1MAY; X-ray; 1.80 A; A=24-246.
DR PDB; 1MTS; X-ray; 1.90 A; A=24-246.
DR PDB; 1MTU; X-ray; 1.90 A; A=24-246.
DR PDB; 1MTV; X-ray; 1.90 A; A=24-246.
DR PDB; 1MTW; X-ray; 1.90 A; A=24-246.
DR PDB; 1N6X; X-ray; 1.40 A; A=24-246.
DR PDB; 1N6Y; X-ray; 1.40 A; A=24-246.
DR PDB; 1NC6; X-ray; 1.90 A; A=24-246.
DR PDB; 1NTP; Neutron; 1.80 A; A=24-246.
DR PDB; 1O2H; X-ray; 1.77 A; A=24-246.
DR PDB; 1O2I; X-ray; 1.50 A; A=24-246.
DR PDB; 1O2J; X-ray; 1.65 A; A=24-246.
DR PDB; 1O2K; X-ray; 1.63 A; A=24-246.
DR PDB; 1O2L; X-ray; 1.68 A; A=24-246.
DR PDB; 1O2M; X-ray; 1.69 A; A=24-246.
DR PDB; 1O2N; X-ray; 1.50 A; A=24-246.
DR PDB; 1O2O; X-ray; 1.63 A; A=24-246.
DR PDB; 1O2P; X-ray; 1.47 A; A=24-246.
DR PDB; 1O2Q; X-ray; 1.50 A; A=24-246.
DR PDB; 1O2R; X-ray; 1.45 A; A=24-246.
DR PDB; 1O2S; X-ray; 1.65 A; A=24-246.
DR PDB; 1O2T; X-ray; 1.62 A; A=24-246.
DR PDB; 1O2U; X-ray; 1.41 A; A=24-246.
DR PDB; 1O2V; X-ray; 1.50 A; A=24-246.
DR PDB; 1O2W; X-ray; 1.38 A; A=24-246.
DR PDB; 1O2X; X-ray; 1.46 A; A=24-246.
DR PDB; 1O2Y; X-ray; 1.45 A; A=24-246.
DR PDB; 1O2Z; X-ray; 1.65 A; A=24-246.
DR PDB; 1O30; X-ray; 1.55 A; A=24-246.
DR PDB; 1O31; X-ray; 1.66 A; A=24-246.
DR PDB; 1O32; X-ray; 1.78 A; A=24-246.
DR PDB; 1O33; X-ray; 1.46 A; A=24-246.
DR PDB; 1O34; X-ray; 1.50 A; A=24-246.
DR PDB; 1O35; X-ray; 1.41 A; A=24-246.
DR PDB; 1O36; X-ray; 1.70 A; A=24-246.
DR PDB; 1O37; X-ray; 1.45 A; A=24-246.
DR PDB; 1O38; X-ray; 1.38 A; A=24-246.
DR PDB; 1O39; X-ray; 1.59 A; A=24-246.
DR PDB; 1O3A; X-ray; 2.00 A; A=24-246.
DR PDB; 1O3B; X-ray; 1.75 A; A=24-246.
DR PDB; 1O3C; X-ray; 1.64 A; A=24-246.
DR PDB; 1O3D; X-ray; 1.33 A; A=24-246.
DR PDB; 1O3E; X-ray; 1.64 A; A=24-246.
DR PDB; 1O3F; X-ray; 1.55 A; A=24-246.
DR PDB; 1O3G; X-ray; 1.55 A; A=24-246.
DR PDB; 1O3H; X-ray; 1.53 A; A=24-246.
DR PDB; 1O3I; X-ray; 1.51 A; A=24-246.
DR PDB; 1O3J; X-ray; 1.40 A; A=24-246.
DR PDB; 1O3K; X-ray; 1.43 A; A=24-246.
DR PDB; 1O3L; X-ray; 1.40 A; A=24-246.
DR PDB; 1O3M; X-ray; 1.55 A; A=24-246.
DR PDB; 1O3N; X-ray; 1.55 A; A=24-246.
DR PDB; 1O3O; X-ray; 1.55 A; A=24-246.
DR PDB; 1OPH; X-ray; 2.30 A; B=4-246.
DR PDB; 1OX1; X-ray; 2.00 A; A=24-246.
DR PDB; 1OYQ; X-ray; 1.90 A; A=24-246.
DR PDB; 1P2I; X-ray; 1.65 A; A=24-246.
DR PDB; 1P2J; X-ray; 1.35 A; A=24-246.
DR PDB; 1P2K; X-ray; 1.60 A; A=24-246.
DR PDB; 1PPC; X-ray; 1.80 A; E=24-246.
DR PDB; 1PPE; X-ray; 2.00 A; E=24-246.
DR PDB; 1PPH; X-ray; 1.90 A; E=24-246.
DR PDB; 1QA0; X-ray; 1.80 A; A=24-246.
DR PDB; 1QB1; X-ray; 1.80 A; A=24-246.
DR PDB; 1QB6; X-ray; 1.80 A; A=24-246.
DR PDB; 1QB9; X-ray; 1.80 A; A=24-246.
DR PDB; 1QBN; X-ray; 1.80 A; A=24-246.
DR PDB; 1QBO; X-ray; 1.80 A; A=24-246.
DR PDB; 1QCP; X-ray; 1.80 A; A=24-246.
DR PDB; 1QL7; X-ray; 2.10 A; A=24-246.
DR PDB; 1QL8; X-ray; 3.00 A; A=24-246.
DR PDB; 1RXP; X-ray; 1.70 A; A=24-246.
DR PDB; 1S0Q; X-ray; 1.02 A; A=24-246.
DR PDB; 1S0R; X-ray; 1.02 A; A=24-246.
DR PDB; 1SBW; X-ray; 1.80 A; A=24-246.
DR PDB; 1SFI; X-ray; 1.65 A; A=24-246.
DR PDB; 1SMF; X-ray; 2.10 A; E=24-246.
DR PDB; 1TAB; X-ray; 2.30 A; E=24-246.
DR PDB; 1TAW; X-ray; 1.80 A; A=24-246.
DR PDB; 1TGB; X-ray; 1.80 A; A=18-246.
DR PDB; 1TGC; X-ray; 1.80 A; A=18-246.
DR PDB; 1TGN; X-ray; 1.65 A; A=18-246.
DR PDB; 1TGS; X-ray; 1.80 A; Z=18-246.
DR PDB; 1TGT; X-ray; 1.70 A; A=18-246.
DR PDB; 1TIO; X-ray; 1.93 A; A=24-246.
DR PDB; 1TLD; X-ray; 1.50 A; A=24-246.
DR PDB; 1TNG; X-ray; 1.80 A; A=18-246.
DR PDB; 1TNH; X-ray; 1.80 A; A=18-246.
DR PDB; 1TNI; X-ray; 1.90 A; A=18-246.
DR PDB; 1TNJ; X-ray; 1.80 A; A=18-246.
DR PDB; 1TNK; X-ray; 1.80 A; A=18-246.
DR PDB; 1TNL; X-ray; 1.90 A; A=18-246.
DR PDB; 1TPA; X-ray; 1.90 A; E=24-246.
DR PDB; 1TPO; X-ray; 1.70 A; A=24-246.
DR PDB; 1TPP; X-ray; 1.40 A; A=24-246.
DR PDB; 1TPS; X-ray; 1.90 A; A=24-246.
DR PDB; 1TX7; X-ray; 1.75 A; A=24-246.
DR PDB; 1TX8; X-ray; 1.70 A; A=24-246.
DR PDB; 1TYN; X-ray; 2.00 A; A=24-246.
DR PDB; 1UTN; X-ray; 1.15 A; A=4-246.
DR PDB; 1UTO; X-ray; 1.15 A; A=4-246.
DR PDB; 1UTP; X-ray; 1.30 A; A=4-246.
DR PDB; 1UTQ; X-ray; 1.15 A; A=4-246.
DR PDB; 1V2J; X-ray; 1.90 A; T=24-246.
DR PDB; 1V2K; X-ray; 2.00 A; T=24-246.
DR PDB; 1V2L; X-ray; 1.60 A; T=24-246.
DR PDB; 1V2M; X-ray; 1.65 A; T=24-246.
DR PDB; 1V2N; X-ray; 1.80 A; T=24-246.
DR PDB; 1V2O; X-ray; 1.62 A; T=24-246.
DR PDB; 1V2P; X-ray; 1.92 A; T=24-246.
DR PDB; 1V2Q; X-ray; 2.30 A; T=24-246.
DR PDB; 1V2R; X-ray; 1.70 A; T=24-246.
DR PDB; 1V2S; X-ray; 1.72 A; T=24-246.
DR PDB; 1V2T; X-ray; 1.90 A; T=24-246.
DR PDB; 1V2U; X-ray; 1.80 A; T=24-246.
DR PDB; 1V2V; X-ray; 1.80 A; T=24-246.
DR PDB; 1V2W; X-ray; 1.75 A; T=24-246.
DR PDB; 1XUF; X-ray; 1.90 A; A=24-246.
DR PDB; 1XUG; X-ray; 1.50 A; A=24-246.
DR PDB; 1XUH; X-ray; 2.20 A; A=24-246.
DR PDB; 1XUI; X-ray; 1.50 A; A=24-246.
DR PDB; 1XUJ; X-ray; 1.92 A; A=24-246.
DR PDB; 1XUK; X-ray; 1.80 A; A=24-246.
DR PDB; 1Y3U; X-ray; 1.80 A; A=24-246.
DR PDB; 1Y3V; X-ray; 1.60 A; A=24-246.
DR PDB; 1Y3W; X-ray; 1.80 A; A=24-246.
DR PDB; 1Y3X; X-ray; 1.70 A; A=24-246.
DR PDB; 1Y3Y; X-ray; 1.75 A; A=24-246.
DR PDB; 1Y59; X-ray; 1.20 A; T=24-246.
DR PDB; 1Y5A; X-ray; 1.40 A; T=24-246.
DR PDB; 1Y5B; X-ray; 1.65 A; T=24-246.
DR PDB; 1Y5U; X-ray; 1.60 A; T=24-246.
DR PDB; 1YP9; X-ray; 2.10 A; A=24-246.
DR PDB; 1YYY; X-ray; 2.10 A; 1=24-246.
DR PDB; 1ZR0; X-ray; 1.80 A; A/C=24-246.
DR PDB; 1ZZZ; X-ray; 1.90 A; A=10-246.
DR PDB; 2A7H; X-ray; 2.10 A; A=24-246.
DR PDB; 2AGE; X-ray; 1.15 A; X=24-246.
DR PDB; 2AGG; X-ray; 1.28 A; X=24-246.
DR PDB; 2AGI; X-ray; 1.14 A; X=24-246.
DR PDB; 2AH4; X-ray; 1.13 A; X=24-246.
DR PDB; 2AYW; X-ray; 0.97 A; A=24-246.
DR PDB; 2BLV; X-ray; 1.20 A; A=24-246.
DR PDB; 2BLW; X-ray; 1.20 A; A=24-246.
DR PDB; 2BTC; X-ray; 1.50 A; E=24-246.
DR PDB; 2BY5; X-ray; 1.30 A; X=4-246.
DR PDB; 2BY6; X-ray; 1.30 A; X=4-246.
DR PDB; 2BY7; X-ray; 1.30 A; X=4-246.
DR PDB; 2BY8; X-ray; 1.30 A; X=4-246.
DR PDB; 2BY9; X-ray; 1.30 A; X=4-246.
DR PDB; 2BYA; X-ray; 1.30 A; X=4-246.
DR PDB; 2BZA; X-ray; 1.90 A; A=24-246.
DR PDB; 2CMY; X-ray; 2.25 A; A=24-246.
DR PDB; 2D8W; X-ray; 2.00 A; A=24-246.
DR PDB; 2F3C; X-ray; 2.50 A; E=24-246.
DR PDB; 2FI3; X-ray; 1.58 A; E=24-246.
DR PDB; 2FI4; X-ray; 1.58 A; E=24-246.
DR PDB; 2FI5; X-ray; 1.58 A; E=24-246.
DR PDB; 2FTL; X-ray; 1.62 A; E=24-246.
DR PDB; 2FTM; X-ray; 1.65 A; A=24-246.
DR PDB; 2FX4; X-ray; 1.65 A; A=24-246.
DR PDB; 2FX6; X-ray; 1.57 A; A=24-246.
DR PDB; 2G55; X-ray; 1.82 A; A=24-246.
DR PDB; 2G5N; X-ray; 1.51 A; A=24-246.
DR PDB; 2G5V; X-ray; 1.45 A; A=24-246.
DR PDB; 2G81; X-ray; 1.55 A; E=24-246.
DR PDB; 2G8T; X-ray; 1.41 A; A=24-246.
DR PDB; 2ILN; X-ray; 2.00 A; A/B=24-246.
DR PDB; 2J9N; X-ray; 1.50 A; A=24-246.
DR PDB; 2O9Q; X-ray; 1.70 A; A=24-246.
DR PDB; 2OTV; X-ray; 1.56 A; A=24-246.
DR PDB; 2OXS; X-ray; 1.32 A; A=24-246.
DR PDB; 2PLX; X-ray; 1.56 A; A=24-246.
DR PDB; 2PTC; X-ray; 1.90 A; E=24-246.
DR PDB; 2PTN; X-ray; 1.55 A; A=24-246.
DR PDB; 2QN5; X-ray; 3.00 A; T=24-246.
DR PDB; 2QYI; X-ray; 2.60 A; A/C=24-246.
DR PDB; 2TGA; X-ray; 1.80 A; A=18-246.
DR PDB; 2TGD; X-ray; 2.10 A; A=18-246.
DR PDB; 2TGP; X-ray; 1.90 A; Z=18-246.
DR PDB; 2TGT; X-ray; 1.70 A; A=18-246.
DR PDB; 2TIO; X-ray; 1.93 A; A=24-246.
DR PDB; 2TLD; X-ray; 2.60 A; E=24-246.
DR PDB; 2TPI; X-ray; 2.10 A; Z=18-246.
DR PDB; 2UUY; X-ray; 1.15 A; A=24-246.
DR PDB; 2XTT; X-ray; 0.93 A; B=24-246.
DR PDB; 2ZDK; X-ray; 1.67 A; A=24-246.
DR PDB; 2ZDL; X-ray; 1.80 A; A=24-246.
DR PDB; 2ZDM; X-ray; 1.93 A; A=24-246.
DR PDB; 2ZDN; X-ray; 1.98 A; A=24-246.
DR PDB; 2ZFS; X-ray; 1.51 A; A=24-246.
DR PDB; 2ZFT; X-ray; 1.76 A; A=24-246.
DR PDB; 2ZHD; X-ray; 1.94 A; A=24-246.
DR PDB; 2ZQ1; X-ray; 1.68 A; A=24-246.
DR PDB; 2ZQ2; X-ray; 1.40 A; A=24-246.
DR PDB; 3A7T; X-ray; 1.75 A; A=24-246.
DR PDB; 3A7V; X-ray; 1.75 A; A=24-246.
DR PDB; 3A7W; X-ray; 1.75 A; A=24-246.
DR PDB; 3A7X; X-ray; 1.75 A; A=24-246.
DR PDB; 3A7Y; X-ray; 1.81 A; A=24-246.
DR PDB; 3A7Z; X-ray; 1.80 A; A=24-246.
DR PDB; 3A80; X-ray; 1.75 A; A=24-246.
DR PDB; 3A81; X-ray; 1.78 A; A=24-246.
DR PDB; 3A82; X-ray; 1.75 A; A=24-246.
DR PDB; 3A83; X-ray; 1.78 A; A=24-246.
DR PDB; 3A84; X-ray; 1.75 A; A=24-246.
DR PDB; 3A85; X-ray; 1.75 A; A=24-246.
DR PDB; 3A86; X-ray; 1.75 A; A=24-246.
DR PDB; 3A87; X-ray; 1.75 A; A=24-246.
DR PDB; 3A88; X-ray; 1.75 A; A=24-246.
DR PDB; 3A89; X-ray; 1.80 A; A=24-246.
DR PDB; 3A8A; X-ray; 1.40 A; A=24-246.
DR PDB; 3A8B; X-ray; 1.75 A; A=24-246.
DR PDB; 3A8C; X-ray; 1.85 A; A=24-246.
DR PDB; 3A8D; X-ray; 1.75 A; A=24-246.
DR PDB; 3AAS; X-ray; 1.75 A; A=24-246.
DR PDB; 3AAU; X-ray; 1.80 A; A=24-246.
DR PDB; 3AAV; X-ray; 1.70 A; A/B=24-246.
DR PDB; 3ATI; X-ray; 1.71 A; A=24-246.
DR PDB; 3ATK; X-ray; 1.74 A; A=24-246.
DR PDB; 3ATL; X-ray; 1.74 A; A=24-246.
DR PDB; 3ATM; X-ray; 1.72 A; A=24-246.
DR PDB; 3BTD; X-ray; 1.90 A; E=24-246.
DR PDB; 3BTE; X-ray; 1.85 A; E=24-246.
DR PDB; 3BTF; X-ray; 1.80 A; E=24-246.
DR PDB; 3BTG; X-ray; 1.90 A; E=24-246.
DR PDB; 3BTH; X-ray; 1.75 A; E=24-246.
DR PDB; 3BTK; X-ray; 1.85 A; E=24-246.
DR PDB; 3BTM; X-ray; 1.80 A; E=24-246.
DR PDB; 3BTQ; X-ray; 1.90 A; E=24-246.
DR PDB; 3BTT; X-ray; 1.90 A; E=24-246.
DR PDB; 3BTW; X-ray; 2.05 A; E=24-246.
DR PDB; 3D65; X-ray; 1.64 A; E=24-246.
DR PDB; 3E8L; X-ray; 2.48 A; A/B=24-246.
DR PDB; 3GY2; X-ray; 1.57 A; A=24-246.
DR PDB; 3GY3; X-ray; 1.70 A; A=24-246.
DR PDB; 3GY4; X-ray; 1.55 A; A=24-246.
DR PDB; 3GY5; X-ray; 1.57 A; A=24-246.
DR PDB; 3GY6; X-ray; 1.70 A; A=24-246.
DR PDB; 3GY7; X-ray; 1.55 A; A=24-246.
DR PDB; 3GY8; X-ray; 1.75 A; A=24-246.
DR PDB; 3I29; X-ray; 2.40 A; A=24-246.
DR PDB; 3ITI; X-ray; 1.55 A; A=24-246.
DR PDB; 3LJJ; X-ray; 1.55 A; A=24-246.
DR PDB; 3LJO; X-ray; 1.50 A; A=24-246.
DR PDB; 3M35; X-ray; 2.20 A; A=24-246.
DR PDB; 3M7Q; X-ray; 1.70 A; A=24-246.
DR PDB; 3MFJ; X-ray; 0.80 A; A=24-246.
DR PDB; 3MI4; X-ray; 0.80 A; A=24-246.
DR PDB; 3NK8; X-ray; 1.15 A; A=24-246.
DR PDB; 3NKK; X-ray; 1.12 A; A=24-246.
DR PDB; 3OTJ; Other; 2.15 A; E=24-246.
DR PDB; 3PLB; X-ray; 1.18 A; A=24-246.
DR PDB; 3PLK; X-ray; 1.53 A; A=24-246.
DR PDB; 3PLP; X-ray; 1.63 A; A=24-246.
DR PDB; 3PM3; X-ray; 1.53 A; A=24-246.
DR PDB; 3PMJ; X-ray; 1.45 A; A=24-246.
DR PDB; 3PTB; X-ray; 1.70 A; A=24-246.
DR PDB; 3PTN; X-ray; 1.70 A; A=24-246.
DR PDB; 3PWB; X-ray; 1.63 A; A=24-246.
DR PDB; 3PWC; X-ray; 1.60 A; A=24-246.
DR PDB; 3PYH; X-ray; 2.00 A; A=24-246.
DR PDB; 3Q00; X-ray; 1.70 A; A=24-246.
DR PDB; 3QK1; X-ray; 2.08 A; A=24-246.
DR PDB; 3RDZ; X-ray; 2.26 A; A/B=24-246.
DR PDB; 3RU4; X-ray; 1.68 A; T=24-246.
DR PDB; 3RXA; X-ray; 1.70 A; A=24-246.
DR PDB; 3RXB; X-ray; 1.70 A; A=24-246.
DR PDB; 3RXC; X-ray; 1.70 A; A=24-246.
DR PDB; 3RXD; X-ray; 1.70 A; A=24-246.
DR PDB; 3RXE; X-ray; 1.70 A; A=24-246.
DR PDB; 3RXF; X-ray; 1.70 A; A=24-246.
DR PDB; 3RXG; X-ray; 1.70 A; A=24-246.
DR PDB; 3RXH; X-ray; 1.70 A; A=24-246.
DR PDB; 3RXI; X-ray; 1.60 A; A=24-246.
DR PDB; 3RXJ; X-ray; 1.70 A; A=24-246.
DR PDB; 3RXK; X-ray; 1.60 A; A=24-246.
DR PDB; 3RXL; X-ray; 1.70 A; A=24-246.
DR PDB; 3RXM; X-ray; 1.70 A; A=24-246.
DR PDB; 3RXO; X-ray; 1.60 A; A=24-246.
DR PDB; 3RXP; X-ray; 1.60 A; A=24-246.
DR PDB; 3RXQ; X-ray; 1.68 A; A=24-246.
DR PDB; 3RXR; X-ray; 1.72 A; A=24-246.
DR PDB; 3RXS; X-ray; 1.74 A; A=24-246.
DR PDB; 3RXT; X-ray; 1.70 A; A=24-246.
DR PDB; 3RXU; X-ray; 1.68 A; A=24-246.
DR PDB; 3RXV; X-ray; 1.70 A; A=24-246.
DR PDB; 3T25; X-ray; 1.70 A; A=24-246.
DR PDB; 3T26; X-ray; 1.70 A; A=24-246.
DR PDB; 3T27; X-ray; 1.95 A; A=24-246.
DR PDB; 3T28; X-ray; 2.80 A; A=24-246.
DR PDB; 3T29; X-ray; 1.75 A; A=24-246.
DR PDB; 3TPI; X-ray; 1.90 A; Z=18-246.
DR PDB; 3UNQ; X-ray; 1.62 A; A=24-246.
DR PDB; 3UNR; X-ray; 1.20 A; A=24-246.
DR PDB; 3UNS; X-ray; 1.80 A; A=24-246.
DR PDB; 3UOP; X-ray; 1.69 A; A=24-246.
DR PDB; 3UPE; X-ray; 1.54 A; A=24-246.
DR PDB; 3UQO; X-ray; 1.80 A; A=24-246.
DR PDB; 3UQV; X-ray; 2.40 A; A=24-246.
DR PDB; 3UUZ; X-ray; 2.10 A; A/B=24-246.
DR PDB; 3UWI; X-ray; 1.43 A; A=24-246.
DR PDB; 3UY9; X-ray; 3.22 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=24-246.
DR PDB; 3V0X; X-ray; 1.90 A; A=24-246.
DR PDB; 3V12; X-ray; 1.80 A; A=24-246.
DR PDB; 3V13; X-ray; 1.63 A; A=24-246.
DR PDB; 3VEQ; X-ray; 2.25 A; B=24-246.
DR PDB; 3VPK; X-ray; 1.94 A; A=24-246.
DR PDB; 4AB8; X-ray; 1.60 A; A=24-246.
DR PDB; 4AB9; X-ray; 1.20 A; A=24-246.
DR PDB; 4ABA; X-ray; 1.25 A; A=24-246.
DR PDB; 4ABB; X-ray; 1.25 A; A=24-246.
DR PDB; 4ABD; X-ray; 1.25 A; A=24-246.
DR PDB; 4ABE; X-ray; 1.30 A; A=24-246.
DR PDB; 4ABF; X-ray; 1.30 A; A=24-246.
DR PDB; 4ABG; X-ray; 1.52 A; A=24-246.
DR PDB; 4ABH; X-ray; 1.25 A; A=24-246.
DR PDB; 4ABI; X-ray; 1.55 A; A=24-246.
DR PDB; 4ABJ; X-ray; 1.45 A; A=24-246.
DR PDB; 4AOQ; X-ray; 2.00 A; A/B/C=24-246.
DR PDB; 4AOR; X-ray; 1.70 A; A/B/C=24-246.
DR PDB; 4B1T; X-ray; 1.78 A; A/C=24-246.
DR PDB; 4B2A; X-ray; 1.89 A; A/C=24-246.
DR PDB; 4B2B; X-ray; 1.36 A; A/C=24-246.
DR PDB; 4B2C; X-ray; 1.43 A; A/C=24-246.
DR PDB; 4GUX; X-ray; 1.80 A; A/B/C=1-246.
DR PDB; 4HGC; X-ray; 1.29 A; A=24-246.
DR PDB; 4I8G; X-ray; 0.80 A; A=24-246.
DR PDB; 4I8H; X-ray; 0.75 A; A=24-246.
DR PDB; 4I8J; X-ray; 0.87 A; A=24-246.
DR PDB; 4I8K; X-ray; 0.85 A; A=24-246.
DR PDB; 4I8L; X-ray; 0.87 A; A=24-246.
DR PDB; 4J2Y; X-ray; 2.00 A; B=24-246.
DR PDB; 4KTS; X-ray; 1.30 A; A=24-246.
DR PDB; 4KTU; X-ray; 1.35 A; A=24-246.
DR PDB; 4MTB; X-ray; 1.22 A; A=24-246.
DR PDB; 4NCY; X-ray; 1.42 A; A=24-246.
DR PDB; 4NIV; X-ray; 1.00 A; A=24-246.
DR PDB; 4NIW; X-ray; 1.31 A; A=24-246.
DR PDB; 4NIX; X-ray; 1.30 A; A=24-246.
DR PDB; 4NIY; X-ray; 2.84 A; A/B/C/D=24-246.
DR PDB; 4TPI; X-ray; 2.20 A; Z=18-246.
DR PDB; 4TPY; X-ray; 1.30 A; A=24-246.
DR PDB; 4U2W; X-ray; 1.00 A; A=24-246.
DR PDB; 4XOJ; X-ray; 0.91 A; A=1-246.
DR PDB; 4Y0Y; X-ray; 1.25 A; E=24-246.
DR PDB; 4Y0Z; X-ray; 1.37 A; E=24-246.
DR PDB; 4Y10; X-ray; 1.37 A; E=24-246.
DR PDB; 4Y11; X-ray; 1.30 A; E=24-246.
DR PDB; 4YTA; X-ray; 1.20 A; A=24-246.
DR PDB; 5EG4; X-ray; 1.32 A; A=24-246.
DR PDB; 5F6M; X-ray; 1.10 A; A=24-246.
DR PDB; 5FXL; X-ray; 1.78 A; A=1-246.
DR PDB; 5GIB; X-ray; 2.70 A; A/B=24-246.
DR PDB; 5GXP; X-ray; 2.80 A; A/B=24-246.
DR PDB; 5JYI; X-ray; 1.91 A; A=1-246.
DR PDB; 5K7R; EM; 1.70 A; A=24-246.
DR PDB; 5LGO; X-ray; 1.12 A; A=24-246.
DR PDB; 5LH4; X-ray; 1.37 A; A=24-246.
DR PDB; 5LH8; X-ray; 1.54 A; A=24-246.
DR PDB; 5MN1; X-ray; 0.79 A; A=24-246.
DR PDB; 5MNA; X-ray; 1.44 A; A=24-246.
DR PDB; 5MNB; X-ray; 0.94 A; A=24-246.
DR PDB; 5MNC; X-ray; 0.92 A; A=24-246.
DR PDB; 5MNE; X-ray; 1.01 A; A=24-246.
DR PDB; 5MNF; X-ray; 0.99 A; A=24-246.
DR PDB; 5MNG; X-ray; 0.86 A; A=24-246.
DR PDB; 5MNH; X-ray; 0.93 A; A=24-246.
DR PDB; 5MNK; X-ray; 0.80 A; A=24-246.
DR PDB; 5MNL; X-ray; 1.04 A; A=24-246.
DR PDB; 5MNM; X-ray; 0.98 A; A=24-246.
DR PDB; 5MNN; X-ray; 0.86 A; A=24-246.
DR PDB; 5MNO; X-ray; 0.96 A; A=24-246.
DR PDB; 5MNP; X-ray; 1.01 A; A=24-246.
DR PDB; 5MNQ; X-ray; 1.34 A; A=24-246.
DR PDB; 5MNX; Neutron; 1.42 A; A=24-246.
DR PDB; 5MNY; Neutron; 1.43 A; A=24-246.
DR PDB; 5MNZ; Neutron; 1.45 A; A=24-246.
DR PDB; 5MO0; Neutron; 1.50 A; A=24-246.
DR PDB; 5MO1; Neutron; 1.49 A; A=24-246.
DR PDB; 5MO2; Neutron; 1.50 A; A=24-246.
DR PDB; 5MON; Other; 0.94 A; A=24-246.
DR PDB; 5MOO; Other; 1.44 A; A=24-246.
DR PDB; 5MOP; Other; 0.99 A; A=24-246.
DR PDB; 5MOQ; Other; 0.93 A; A=24-246.
DR PDB; 5MOR; Other; 0.98 A; A=24-246.
DR PDB; 5MOS; Other; 0.96 A; A=24-246.
DR PDB; 5PTP; X-ray; 1.34 A; A=24-246.
DR PDB; 5T3H; X-ray; 1.55 A; A=24-246.
DR PDB; 6AVL; X-ray; 2.00 A; A=24-246.
DR PDB; 6B6N; X-ray; 2.00 A; A=24-246.
DR PDB; 6B6O; X-ray; 2.40 A; A=24-246.
DR PDB; 6B6P; X-ray; 2.00 A; A=24-246.
DR PDB; 6B6Q; X-ray; 2.00 A; A=24-246.
DR PDB; 6B6R; X-ray; 2.00 A; A=24-246.
DR PDB; 6B6S; X-ray; 2.00 A; A=24-246.
DR PDB; 6B6T; X-ray; 2.00 A; A=24-246.
DR PDB; 6BFP; X-ray; 1.29 A; A=24-246.
DR PDB; 6BVH; X-ray; 1.93 A; A=24-246.
DR PDB; 6DWF; X-ray; 1.94 A; A/B/C/D/E/F=24-246.
DR PDB; 6DWH; X-ray; 2.00 A; A/B/C/D/E/F=24-246.
DR PDB; 6DWR; X-ray; 1.32 A; A=24-246.
DR PDB; 6DWU; X-ray; 3.96 A; AA/AC/AE/AG/AI/AK/AM/AO/AQ/AS/AU/BA/BC/BE/BG/BI/BK/BM/BO/BQ/BS/BU/CA/CC/CE/CG/CI/CK/CM/CO=24-246.
DR PDB; 6DZF; X-ray; 2.20 A; A=24-246.
DR PDB; 6E5M; X-ray; 1.61 A; A=24-246.
DR PDB; 6EAT; X-ray; 1.15 A; A=24-246.
DR PDB; 6EAU; X-ray; 1.18 A; A=24-246.
DR PDB; 6EAV; X-ray; 1.39 A; A=24-246.
DR PDB; 6EAW; X-ray; 1.29 A; A=24-246.
DR PDB; 6EAX; X-ray; 1.19 A; A=24-246.
DR PDB; 6FID; X-ray; 2.20 A; A=24-246.
DR PDB; 6MRQ; X-ray; 1.29 A; A=24-246.
DR PDB; 6QIH; X-ray; 1.42 A; A=24-246.
DR PDB; 6QL0; X-ray; 1.63 A; A=1-246.
DR PDB; 6SUX; X-ray; 1.16 A; A=24-246.
DR PDB; 6SV0; X-ray; 1.16 A; A=24-246.
DR PDB; 6SV6; X-ray; 1.15 A; A=24-246.
DR PDB; 6SV8; X-ray; 1.15 A; A=24-246.
DR PDB; 6SV9; X-ray; 1.15 A; A=24-246.
DR PDB; 6SVB; X-ray; 1.15 A; A=24-246.
DR PDB; 6SVD; X-ray; 1.15 A; A=24-246.
DR PDB; 6SVG; X-ray; 1.16 A; A=24-246.
DR PDB; 6SVI; X-ray; 1.16 A; A=24-246.
DR PDB; 6SVJ; X-ray; 1.16 A; A=24-246.
DR PDB; 6SVN; X-ray; 1.16 A; A=24-246.
DR PDB; 6SVR; X-ray; 1.16 A; A=24-246.
DR PDB; 6SVU; X-ray; 1.15 A; A=24-246.
DR PDB; 6SVV; X-ray; 1.15 A; A=24-246.
DR PDB; 6SVW; X-ray; 1.16 A; A=24-246.
DR PDB; 6SVX; X-ray; 1.16 A; A=24-246.
DR PDB; 6SVZ; X-ray; 1.15 A; A=24-246.
DR PDB; 6SW0; X-ray; 1.15 A; A=24-246.
DR PDB; 6SWV; X-ray; 1.43 A; AAA=1-246.
DR PDB; 6SY3; X-ray; 0.95 A; A=1-246.
DR PDB; 6T0M; X-ray; 1.51 A; A=1-246.
DR PDB; 6T0P; X-ray; 1.19 A; A=1-246.
DR PDB; 6T5W; X-ray; 1.13 A; A=1-246.
DR PDB; 6T9U; X-ray; 1.07 A; A=1-246.
DR PDB; 6T9V; X-ray; 1.13 A; A=1-246.
DR PDB; 6U22; X-ray; 1.42 A; A=24-246.
DR PDB; 6VXY; X-ray; 1.40 A; A=24-246.
DR PDB; 6XYG; X-ray; 1.50 A; A=24-246.
DR PDB; 6XYK; X-ray; 1.50 A; A=24-246.
DR PDB; 6YDY; X-ray; 1.45 A; A=1-246.
DR PDB; 6YIS; X-ray; 1.19 A; A=1-246.
DR PDB; 6YIT; X-ray; 1.25 A; A=24-246.
DR PDB; 6YIU; X-ray; 1.36 A; A=24-246.
DR PDB; 6YIV; X-ray; 0.95 A; A=24-246.
DR PDB; 6YIW; X-ray; 0.97 A; A=24-246.
DR PDB; 6YIX; X-ray; 1.31 A; A=24-246.
DR PDB; 6YIY; X-ray; 1.11 A; A=24-246.
DR PDB; 6YZA; X-ray; 1.30 A; A=24-246.
DR PDB; 6YZC; X-ray; 1.42 A; A=24-246.
DR PDB; 6ZFJ; X-ray; 1.00 A; A=24-246.
DR PDB; 6ZFK; X-ray; 1.10 A; A=24-246.
DR PDB; 6ZQ2; X-ray; 1.29 A; A=24-246.
DR PDB; 7AL8; X-ray; 2.85 A; B/E/H/K/N/Q/T/U=24-246.
DR PDB; 7AYS; X-ray; 2.10 A; A=24-246.
DR PDB; 7BRV; X-ray; 1.55 A; A=24-246.
DR PDB; 7BRW; X-ray; 1.60 A; A=24-246.
DR PDB; 7BRX; X-ray; 1.35 A; A=24-246.
DR PDB; 7BRY; X-ray; 1.65 A; A=24-246.
DR PDB; 7BRZ; X-ray; 1.30 A; A=24-246.
DR PDB; 7BS0; X-ray; 1.85 A; A=24-246.
DR PDB; 7BS1; X-ray; 1.50 A; A=24-246.
DR PDB; 7BS2; X-ray; 1.80 A; A=24-246.
DR PDB; 7BS3; X-ray; 1.28 A; A=24-246.
DR PDB; 7BS4; X-ray; 1.04 A; A=24-246.
DR PDB; 7BS5; X-ray; 1.17 A; A=24-246.
DR PDB; 7BS6; X-ray; 1.04 A; A=24-246.
DR PDB; 7BS7; X-ray; 1.04 A; A=24-246.
DR PDB; 7BS8; X-ray; 1.37 A; A=24-246.
DR PDB; 7BS9; X-ray; 1.05 A; A=24-246.
DR PDB; 7BSA; X-ray; 1.22 A; A=24-246.
DR PDB; 7JR1; X-ray; 2.05 A; A/B/C/D/E/F=24-246.
DR PDB; 7JR2; X-ray; 1.85 A; A/B/C/D/E/F=24-246.
DR PDB; 7JWX; X-ray; 2.38 A; A/B/C/D=24-246.
DR PDB; 7PH1; X-ray; 1.18 A; E=24-246.
DR PDBsum; 1AQ7; -.
DR PDBsum; 1AUJ; -.
DR PDBsum; 1AZ8; -.
DR PDBsum; 1BJU; -.
DR PDBsum; 1BJV; -.
DR PDBsum; 1BTP; -.
DR PDBsum; 1BTW; -.
DR PDBsum; 1BTX; -.
DR PDBsum; 1BTY; -.
DR PDBsum; 1BTZ; -.
DR PDBsum; 1C1N; -.
DR PDBsum; 1C1O; -.
DR PDBsum; 1C1P; -.
DR PDBsum; 1C1Q; -.
DR PDBsum; 1C1R; -.
DR PDBsum; 1C1S; -.
DR PDBsum; 1C1T; -.
DR PDBsum; 1C2D; -.
DR PDBsum; 1C2E; -.
DR PDBsum; 1C2F; -.
DR PDBsum; 1C2G; -.
DR PDBsum; 1C2H; -.
DR PDBsum; 1C2I; -.
DR PDBsum; 1C2J; -.
DR PDBsum; 1C2K; -.
DR PDBsum; 1C2L; -.
DR PDBsum; 1C2M; -.
DR PDBsum; 1C5P; -.
DR PDBsum; 1C5Q; -.
DR PDBsum; 1C5R; -.
DR PDBsum; 1C5S; -.
DR PDBsum; 1C5T; -.
DR PDBsum; 1C5U; -.
DR PDBsum; 1C5V; -.
DR PDBsum; 1C9T; -.
DR PDBsum; 1CE5; -.
DR PDBsum; 1D6R; -.
DR PDBsum; 1EB2; -.
DR PDBsum; 1EJM; -.
DR PDBsum; 1EZX; -.
DR PDBsum; 1F0T; -.
DR PDBsum; 1F0U; -.
DR PDBsum; 1F2S; -.
DR PDBsum; 1G36; -.
DR PDBsum; 1G3B; -.
DR PDBsum; 1G3C; -.
DR PDBsum; 1G3D; -.
DR PDBsum; 1G3E; -.
DR PDBsum; 1G9I; -.
DR PDBsum; 1GBT; -.
DR PDBsum; 1GHZ; -.
DR PDBsum; 1GI0; -.
DR PDBsum; 1GI1; -.
DR PDBsum; 1GI2; -.
DR PDBsum; 1GI3; -.
DR PDBsum; 1GI4; -.
DR PDBsum; 1GI5; -.
DR PDBsum; 1GI6; -.
DR PDBsum; 1GJ6; -.
DR PDBsum; 1HJ9; -.
DR PDBsum; 1J8A; -.
DR PDBsum; 1JIR; -.
DR PDBsum; 1JRS; -.
DR PDBsum; 1JRT; -.
DR PDBsum; 1K1I; -.
DR PDBsum; 1K1J; -.
DR PDBsum; 1K1L; -.
DR PDBsum; 1K1M; -.
DR PDBsum; 1K1N; -.
DR PDBsum; 1K1O; -.
DR PDBsum; 1K1P; -.
DR PDBsum; 1LQE; -.
DR PDBsum; 1MAX; -.
DR PDBsum; 1MAY; -.
DR PDBsum; 1MTS; -.
DR PDBsum; 1MTU; -.
DR PDBsum; 1MTV; -.
DR PDBsum; 1MTW; -.
DR PDBsum; 1N6X; -.
DR PDBsum; 1N6Y; -.
DR PDBsum; 1NC6; -.
DR PDBsum; 1NTP; -.
DR PDBsum; 1O2H; -.
DR PDBsum; 1O2I; -.
DR PDBsum; 1O2J; -.
DR PDBsum; 1O2K; -.
DR PDBsum; 1O2L; -.
DR PDBsum; 1O2M; -.
DR PDBsum; 1O2N; -.
DR PDBsum; 1O2O; -.
DR PDBsum; 1O2P; -.
DR PDBsum; 1O2Q; -.
DR PDBsum; 1O2R; -.
DR PDBsum; 1O2S; -.
DR PDBsum; 1O2T; -.
DR PDBsum; 1O2U; -.
DR PDBsum; 1O2V; -.
DR PDBsum; 1O2W; -.
DR PDBsum; 1O2X; -.
DR PDBsum; 1O2Y; -.
DR PDBsum; 1O2Z; -.
DR PDBsum; 1O30; -.
DR PDBsum; 1O31; -.
DR PDBsum; 1O32; -.
DR PDBsum; 1O33; -.
DR PDBsum; 1O34; -.
DR PDBsum; 1O35; -.
DR PDBsum; 1O36; -.
DR PDBsum; 1O37; -.
DR PDBsum; 1O38; -.
DR PDBsum; 1O39; -.
DR PDBsum; 1O3A; -.
DR PDBsum; 1O3B; -.
DR PDBsum; 1O3C; -.
DR PDBsum; 1O3D; -.
DR PDBsum; 1O3E; -.
DR PDBsum; 1O3F; -.
DR PDBsum; 1O3G; -.
DR PDBsum; 1O3H; -.
DR PDBsum; 1O3I; -.
DR PDBsum; 1O3J; -.
DR PDBsum; 1O3K; -.
DR PDBsum; 1O3L; -.
DR PDBsum; 1O3M; -.
DR PDBsum; 1O3N; -.
DR PDBsum; 1O3O; -.
DR PDBsum; 1OPH; -.
DR PDBsum; 1OX1; -.
DR PDBsum; 1OYQ; -.
DR PDBsum; 1P2I; -.
DR PDBsum; 1P2J; -.
DR PDBsum; 1P2K; -.
DR PDBsum; 1PPC; -.
DR PDBsum; 1PPE; -.
DR PDBsum; 1PPH; -.
DR PDBsum; 1QA0; -.
DR PDBsum; 1QB1; -.
DR PDBsum; 1QB6; -.
DR PDBsum; 1QB9; -.
DR PDBsum; 1QBN; -.
DR PDBsum; 1QBO; -.
DR PDBsum; 1QCP; -.
DR PDBsum; 1QL7; -.
DR PDBsum; 1QL8; -.
DR PDBsum; 1RXP; -.
DR PDBsum; 1S0Q; -.
DR PDBsum; 1S0R; -.
DR PDBsum; 1SBW; -.
DR PDBsum; 1SFI; -.
DR PDBsum; 1SMF; -.
DR PDBsum; 1TAB; -.
DR PDBsum; 1TAW; -.
DR PDBsum; 1TGB; -.
DR PDBsum; 1TGC; -.
DR PDBsum; 1TGN; -.
DR PDBsum; 1TGS; -.
DR PDBsum; 1TGT; -.
DR PDBsum; 1TIO; -.
DR PDBsum; 1TLD; -.
DR PDBsum; 1TNG; -.
DR PDBsum; 1TNH; -.
DR PDBsum; 1TNI; -.
DR PDBsum; 1TNJ; -.
DR PDBsum; 1TNK; -.
DR PDBsum; 1TNL; -.
DR PDBsum; 1TPA; -.
DR PDBsum; 1TPO; -.
DR PDBsum; 1TPP; -.
DR PDBsum; 1TPS; -.
DR PDBsum; 1TX7; -.
DR PDBsum; 1TX8; -.
DR PDBsum; 1TYN; -.
DR PDBsum; 1UTN; -.
DR PDBsum; 1UTO; -.
DR PDBsum; 1UTP; -.
DR PDBsum; 1UTQ; -.
DR PDBsum; 1V2J; -.
DR PDBsum; 1V2K; -.
DR PDBsum; 1V2L; -.
DR PDBsum; 1V2M; -.
DR PDBsum; 1V2N; -.
DR PDBsum; 1V2O; -.
DR PDBsum; 1V2P; -.
DR PDBsum; 1V2Q; -.
DR PDBsum; 1V2R; -.
DR PDBsum; 1V2S; -.
DR PDBsum; 1V2T; -.
DR PDBsum; 1V2U; -.
DR PDBsum; 1V2V; -.
DR PDBsum; 1V2W; -.
DR PDBsum; 1XUF; -.
DR PDBsum; 1XUG; -.
DR PDBsum; 1XUH; -.
DR PDBsum; 1XUI; -.
DR PDBsum; 1XUJ; -.
DR PDBsum; 1XUK; -.
DR PDBsum; 1Y3U; -.
DR PDBsum; 1Y3V; -.
DR PDBsum; 1Y3W; -.
DR PDBsum; 1Y3X; -.
DR PDBsum; 1Y3Y; -.
DR PDBsum; 1Y59; -.
DR PDBsum; 1Y5A; -.
DR PDBsum; 1Y5B; -.
DR PDBsum; 1Y5U; -.
DR PDBsum; 1YP9; -.
DR PDBsum; 1YYY; -.
DR PDBsum; 1ZR0; -.
DR PDBsum; 1ZZZ; -.
DR PDBsum; 2A7H; -.
DR PDBsum; 2AGE; -.
DR PDBsum; 2AGG; -.
DR PDBsum; 2AGI; -.
DR PDBsum; 2AH4; -.
DR PDBsum; 2AYW; -.
DR PDBsum; 2BLV; -.
DR PDBsum; 2BLW; -.
DR PDBsum; 2BTC; -.
DR PDBsum; 2BY5; -.
DR PDBsum; 2BY6; -.
DR PDBsum; 2BY7; -.
DR PDBsum; 2BY8; -.
DR PDBsum; 2BY9; -.
DR PDBsum; 2BYA; -.
DR PDBsum; 2BZA; -.
DR PDBsum; 2CMY; -.
DR PDBsum; 2D8W; -.
DR PDBsum; 2F3C; -.
DR PDBsum; 2FI3; -.
DR PDBsum; 2FI4; -.
DR PDBsum; 2FI5; -.
DR PDBsum; 2FTL; -.
DR PDBsum; 2FTM; -.
DR PDBsum; 2FX4; -.
DR PDBsum; 2FX6; -.
DR PDBsum; 2G55; -.
DR PDBsum; 2G5N; -.
DR PDBsum; 2G5V; -.
DR PDBsum; 2G81; -.
DR PDBsum; 2G8T; -.
DR PDBsum; 2ILN; -.
DR PDBsum; 2J9N; -.
DR PDBsum; 2O9Q; -.
DR PDBsum; 2OTV; -.
DR PDBsum; 2OXS; -.
DR PDBsum; 2PLX; -.
DR PDBsum; 2PTC; -.
DR PDBsum; 2PTN; -.
DR PDBsum; 2QN5; -.
DR PDBsum; 2QYI; -.
DR PDBsum; 2TGA; -.
DR PDBsum; 2TGD; -.
DR PDBsum; 2TGP; -.
DR PDBsum; 2TGT; -.
DR PDBsum; 2TIO; -.
DR PDBsum; 2TLD; -.
DR PDBsum; 2TPI; -.
DR PDBsum; 2UUY; -.
DR PDBsum; 2XTT; -.
DR PDBsum; 2ZDK; -.
DR PDBsum; 2ZDL; -.
DR PDBsum; 2ZDM; -.
DR PDBsum; 2ZDN; -.
DR PDBsum; 2ZFS; -.
DR PDBsum; 2ZFT; -.
DR PDBsum; 2ZHD; -.
DR PDBsum; 2ZQ1; -.
DR PDBsum; 2ZQ2; -.
DR PDBsum; 3A7T; -.
DR PDBsum; 3A7V; -.
DR PDBsum; 3A7W; -.
DR PDBsum; 3A7X; -.
DR PDBsum; 3A7Y; -.
DR PDBsum; 3A7Z; -.
DR PDBsum; 3A80; -.
DR PDBsum; 3A81; -.
DR PDBsum; 3A82; -.
DR PDBsum; 3A83; -.
DR PDBsum; 3A84; -.
DR PDBsum; 3A85; -.
DR PDBsum; 3A86; -.
DR PDBsum; 3A87; -.
DR PDBsum; 3A88; -.
DR PDBsum; 3A89; -.
DR PDBsum; 3A8A; -.
DR PDBsum; 3A8B; -.
DR PDBsum; 3A8C; -.
DR PDBsum; 3A8D; -.
DR PDBsum; 3AAS; -.
DR PDBsum; 3AAU; -.
DR PDBsum; 3AAV; -.
DR PDBsum; 3ATI; -.
DR PDBsum; 3ATK; -.
DR PDBsum; 3ATL; -.
DR PDBsum; 3ATM; -.
DR PDBsum; 3BTD; -.
DR PDBsum; 3BTE; -.
DR PDBsum; 3BTF; -.
DR PDBsum; 3BTG; -.
DR PDBsum; 3BTH; -.
DR PDBsum; 3BTK; -.
DR PDBsum; 3BTM; -.
DR PDBsum; 3BTQ; -.
DR PDBsum; 3BTT; -.
DR PDBsum; 3BTW; -.
DR PDBsum; 3D65; -.
DR PDBsum; 3E8L; -.
DR PDBsum; 3GY2; -.
DR PDBsum; 3GY3; -.
DR PDBsum; 3GY4; -.
DR PDBsum; 3GY5; -.
DR PDBsum; 3GY6; -.
DR PDBsum; 3GY7; -.
DR PDBsum; 3GY8; -.
DR PDBsum; 3I29; -.
DR PDBsum; 3ITI; -.
DR PDBsum; 3LJJ; -.
DR PDBsum; 3LJO; -.
DR PDBsum; 3M35; -.
DR PDBsum; 3M7Q; -.
DR PDBsum; 3MFJ; -.
DR PDBsum; 3MI4; -.
DR PDBsum; 3NK8; -.
DR PDBsum; 3NKK; -.
DR PDBsum; 3OTJ; -.
DR PDBsum; 3PLB; -.
DR PDBsum; 3PLK; -.
DR PDBsum; 3PLP; -.
DR PDBsum; 3PM3; -.
DR PDBsum; 3PMJ; -.
DR PDBsum; 3PTB; -.
DR PDBsum; 3PTN; -.
DR PDBsum; 3PWB; -.
DR PDBsum; 3PWC; -.
DR PDBsum; 3PYH; -.
DR PDBsum; 3Q00; -.
DR PDBsum; 3QK1; -.
DR PDBsum; 3RDZ; -.
DR PDBsum; 3RU4; -.
DR PDBsum; 3RXA; -.
DR PDBsum; 3RXB; -.
DR PDBsum; 3RXC; -.
DR PDBsum; 3RXD; -.
DR PDBsum; 3RXE; -.
DR PDBsum; 3RXF; -.
DR PDBsum; 3RXG; -.
DR PDBsum; 3RXH; -.
DR PDBsum; 3RXI; -.
DR PDBsum; 3RXJ; -.
DR PDBsum; 3RXK; -.
DR PDBsum; 3RXL; -.
DR PDBsum; 3RXM; -.
DR PDBsum; 3RXO; -.
DR PDBsum; 3RXP; -.
DR PDBsum; 3RXQ; -.
DR PDBsum; 3RXR; -.
DR PDBsum; 3RXS; -.
DR PDBsum; 3RXT; -.
DR PDBsum; 3RXU; -.
DR PDBsum; 3RXV; -.
DR PDBsum; 3T25; -.
DR PDBsum; 3T26; -.
DR PDBsum; 3T27; -.
DR PDBsum; 3T28; -.
DR PDBsum; 3T29; -.
DR PDBsum; 3TPI; -.
DR PDBsum; 3UNQ; -.
DR PDBsum; 3UNR; -.
DR PDBsum; 3UNS; -.
DR PDBsum; 3UOP; -.
DR PDBsum; 3UPE; -.
DR PDBsum; 3UQO; -.
DR PDBsum; 3UQV; -.
DR PDBsum; 3UUZ; -.
DR PDBsum; 3UWI; -.
DR PDBsum; 3UY9; -.
DR PDBsum; 3V0X; -.
DR PDBsum; 3V12; -.
DR PDBsum; 3V13; -.
DR PDBsum; 3VEQ; -.
DR PDBsum; 3VPK; -.
DR PDBsum; 4AB8; -.
DR PDBsum; 4AB9; -.
DR PDBsum; 4ABA; -.
DR PDBsum; 4ABB; -.
DR PDBsum; 4ABD; -.
DR PDBsum; 4ABE; -.
DR PDBsum; 4ABF; -.
DR PDBsum; 4ABG; -.
DR PDBsum; 4ABH; -.
DR PDBsum; 4ABI; -.
DR PDBsum; 4ABJ; -.
DR PDBsum; 4AOQ; -.
DR PDBsum; 4AOR; -.
DR PDBsum; 4B1T; -.
DR PDBsum; 4B2A; -.
DR PDBsum; 4B2B; -.
DR PDBsum; 4B2C; -.
DR PDBsum; 4GUX; -.
DR PDBsum; 4HGC; -.
DR PDBsum; 4I8G; -.
DR PDBsum; 4I8H; -.
DR PDBsum; 4I8J; -.
DR PDBsum; 4I8K; -.
DR PDBsum; 4I8L; -.
DR PDBsum; 4J2Y; -.
DR PDBsum; 4KTS; -.
DR PDBsum; 4KTU; -.
DR PDBsum; 4MTB; -.
DR PDBsum; 4NCY; -.
DR PDBsum; 4NIV; -.
DR PDBsum; 4NIW; -.
DR PDBsum; 4NIX; -.
DR PDBsum; 4NIY; -.
DR PDBsum; 4TPI; -.
DR PDBsum; 4TPY; -.
DR PDBsum; 4U2W; -.
DR PDBsum; 4XOJ; -.
DR PDBsum; 4Y0Y; -.
DR PDBsum; 4Y0Z; -.
DR PDBsum; 4Y10; -.
DR PDBsum; 4Y11; -.
DR PDBsum; 4YTA; -.
DR PDBsum; 5EG4; -.
DR PDBsum; 5F6M; -.
DR PDBsum; 5FXL; -.
DR PDBsum; 5GIB; -.
DR PDBsum; 5GXP; -.
DR PDBsum; 5JYI; -.
DR PDBsum; 5K7R; -.
DR PDBsum; 5LGO; -.
DR PDBsum; 5LH4; -.
DR PDBsum; 5LH8; -.
DR PDBsum; 5MN1; -.
DR PDBsum; 5MNA; -.
DR PDBsum; 5MNB; -.
DR PDBsum; 5MNC; -.
DR PDBsum; 5MNE; -.
DR PDBsum; 5MNF; -.
DR PDBsum; 5MNG; -.
DR PDBsum; 5MNH; -.
DR PDBsum; 5MNK; -.
DR PDBsum; 5MNL; -.
DR PDBsum; 5MNM; -.
DR PDBsum; 5MNN; -.
DR PDBsum; 5MNO; -.
DR PDBsum; 5MNP; -.
DR PDBsum; 5MNQ; -.
DR PDBsum; 5MNX; -.
DR PDBsum; 5MNY; -.
DR PDBsum; 5MNZ; -.
DR PDBsum; 5MO0; -.
DR PDBsum; 5MO1; -.
DR PDBsum; 5MO2; -.
DR PDBsum; 5MON; -.
DR PDBsum; 5MOO; -.
DR PDBsum; 5MOP; -.
DR PDBsum; 5MOQ; -.
DR PDBsum; 5MOR; -.
DR PDBsum; 5MOS; -.
DR PDBsum; 5PTP; -.
DR PDBsum; 5T3H; -.
DR PDBsum; 6AVL; -.
DR PDBsum; 6B6N; -.
DR PDBsum; 6B6O; -.
DR PDBsum; 6B6P; -.
DR PDBsum; 6B6Q; -.
DR PDBsum; 6B6R; -.
DR PDBsum; 6B6S; -.
DR PDBsum; 6B6T; -.
DR PDBsum; 6BFP; -.
DR PDBsum; 6BVH; -.
DR PDBsum; 6DWF; -.
DR PDBsum; 6DWH; -.
DR PDBsum; 6DWR; -.
DR PDBsum; 6DWU; -.
DR PDBsum; 6DZF; -.
DR PDBsum; 6E5M; -.
DR PDBsum; 6EAT; -.
DR PDBsum; 6EAU; -.
DR PDBsum; 6EAV; -.
DR PDBsum; 6EAW; -.
DR PDBsum; 6EAX; -.
DR PDBsum; 6FID; -.
DR PDBsum; 6MRQ; -.
DR PDBsum; 6QIH; -.
DR PDBsum; 6QL0; -.
DR PDBsum; 6SUX; -.
DR PDBsum; 6SV0; -.
DR PDBsum; 6SV6; -.
DR PDBsum; 6SV8; -.
DR PDBsum; 6SV9; -.
DR PDBsum; 6SVB; -.
DR PDBsum; 6SVD; -.
DR PDBsum; 6SVG; -.
DR PDBsum; 6SVI; -.
DR PDBsum; 6SVJ; -.
DR PDBsum; 6SVN; -.
DR PDBsum; 6SVR; -.
DR PDBsum; 6SVU; -.
DR PDBsum; 6SVV; -.
DR PDBsum; 6SVW; -.
DR PDBsum; 6SVX; -.
DR PDBsum; 6SVZ; -.
DR PDBsum; 6SW0; -.
DR PDBsum; 6SWV; -.
DR PDBsum; 6SY3; -.
DR PDBsum; 6T0M; -.
DR PDBsum; 6T0P; -.
DR PDBsum; 6T5W; -.
DR PDBsum; 6T9U; -.
DR PDBsum; 6T9V; -.
DR PDBsum; 6U22; -.
DR PDBsum; 6VXY; -.
DR PDBsum; 6XYG; -.
DR PDBsum; 6XYK; -.
DR PDBsum; 6YDY; -.
DR PDBsum; 6YIS; -.
DR PDBsum; 6YIT; -.
DR PDBsum; 6YIU; -.
DR PDBsum; 6YIV; -.
DR PDBsum; 6YIW; -.
DR PDBsum; 6YIX; -.
DR PDBsum; 6YIY; -.
DR PDBsum; 6YZA; -.
DR PDBsum; 6YZC; -.
DR PDBsum; 6ZFJ; -.
DR PDBsum; 6ZFK; -.
DR PDBsum; 6ZQ2; -.
DR PDBsum; 7AL8; -.
DR PDBsum; 7AYS; -.
DR PDBsum; 7BRV; -.
DR PDBsum; 7BRW; -.
DR PDBsum; 7BRX; -.
DR PDBsum; 7BRY; -.
DR PDBsum; 7BRZ; -.
DR PDBsum; 7BS0; -.
DR PDBsum; 7BS1; -.
DR PDBsum; 7BS2; -.
DR PDBsum; 7BS3; -.
DR PDBsum; 7BS4; -.
DR PDBsum; 7BS5; -.
DR PDBsum; 7BS6; -.
DR PDBsum; 7BS7; -.
DR PDBsum; 7BS8; -.
DR PDBsum; 7BS9; -.
DR PDBsum; 7BSA; -.
DR PDBsum; 7JR1; -.
DR PDBsum; 7JR2; -.
DR PDBsum; 7JWX; -.
DR PDBsum; 7PH1; -.
DR AlphaFoldDB; P00760; -.
DR PCDDB; P00760; -.
DR SASBDB; P00760; -.
DR SMR; P00760; -.
DR BioGRID; 542655; 1.
DR IntAct; P00760; 5.
DR MINT; P00760; -.
DR STRING; 9913.ENSBTAP00000004737; -.
DR BindingDB; P00760; -.
DR ChEMBL; CHEMBL3769; -.
DR DrugCentral; P00760; -.
DR MEROPS; S01.151; -.
DR PaxDb; P00760; -.
DR PeptideAtlas; P00760; -.
DR PRIDE; P00760; -.
DR Ensembl; ENSBTAT00000004737; ENSBTAP00000004737; ENSBTAG00000052726.
DR Ensembl; ENSBTAT00000033479; ENSBTAP00000033392; ENSBTAG00000050323.
DR GeneID; 615026; -.
DR GeneID; 780933; -.
DR KEGG; bta:615026; -.
DR KEGG; bta:780933; -.
DR CTD; 5644; -.
DR VEuPathDB; HostDB:ENSBTAG00000050323; -.
DR VEuPathDB; HostDB:ENSBTAG00000052726; -.
DR eggNOG; KOG3627; Eukaryota.
DR GeneTree; ENSGT01050000244883; -.
DR HOGENOM; CLU_006842_7_0_1; -.
DR InParanoid; P00760; -.
DR OMA; CNSELQG; -.
DR OrthoDB; 1314811at2759; -.
DR TreeFam; TF331065; -.
DR BRENDA; 3.4.21.4; 908.
DR SABIO-RK; P00760; -.
DR EvolutionaryTrace; P00760; -.
DR PRO; PR:P00760; -.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000050323; Expressed in urinary bladder and 32 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0097180; C:serine protease inhibitor complex; IDA:CAFA.
DR GO; GO:0004175; F:endopeptidase activity; IDA:CAFA.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IDA:CAFA.
DR GO; GO:0097655; F:serpin family protein binding; IDA:CAFA.
DR GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IDA:CAFA.
DR CDD; cd00190; Tryp_SPc; 1.
DR DisProt; DP00728; -.
DR Gene3D; 2.40.10.10; -; 2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; SSF50494; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Calcium; Digestion; Direct protein sequencing;
KW Disulfide bond; Hydrolase; Metal-binding; Protease; Reference proteome;
KW Secreted; Serine protease; Signal; Zymogen.
FT SIGNAL 1..17
FT /evidence="ECO:0000269|PubMed:5967094"
FT PROPEP 18..23
FT /note="Activation peptide"
FT /id="PRO_0000028185"
FT CHAIN 24..246
FT /note="Serine protease 1"
FT /id="PRO_0000028186"
FT CHAIN 24..148
FT /note="Alpha-trypsin chain 1"
FT /id="PRO_0000028187"
FT CHAIN 149..246
FT /note="Alpha-trypsin chain 2"
FT /id="PRO_0000028188"
FT DOMAIN 24..244
FT /note="Peptidase S1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT ACT_SITE 63
FT /note="Charge relay system"
FT ACT_SITE 107
FT /note="Charge relay system"
FT ACT_SITE 200
FT /note="Charge relay system"
FT BINDING 75
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT BINDING 77
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT BINDING 80
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT BINDING 85
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT BINDING 194..195
FT /ligand="substrate"
FT BINDING 197..198
FT /ligand="substrate"
FT BINDING 200
FT /ligand="substrate"
FT DISULFID 30..160
FT /evidence="ECO:0000269|PubMed:32787139,
FT ECO:0007744|PDB:6MRQ"
FT DISULFID 48..64
FT /evidence="ECO:0000269|PubMed:32787139,
FT ECO:0007744|PDB:6MRQ"
FT DISULFID 132..233
FT /evidence="ECO:0000269|PubMed:32787139,
FT ECO:0007744|PDB:6MRQ"
FT DISULFID 139..206
FT /evidence="ECO:0000269|PubMed:32787139,
FT ECO:0007744|PDB:6MRQ"
FT DISULFID 171..185
FT /evidence="ECO:0000269|PubMed:32787139,
FT ECO:0007744|PDB:6MRQ"
FT DISULFID 196..220
FT /evidence="ECO:0000269|PubMed:32787139,
FT ECO:0007744|PDB:6MRQ"
FT TURN 23..26
FT /evidence="ECO:0007829|PDB:1TGS"
FT TURN 32..34
FT /evidence="ECO:0007829|PDB:1TGS"
FT STRAND 38..52
FT /evidence="ECO:0007829|PDB:4I8H"
FT STRAND 54..60
FT /evidence="ECO:0007829|PDB:4I8H"
FT HELIX 62..64
FT /evidence="ECO:0007829|PDB:4I8H"
FT STRAND 70..74
FT /evidence="ECO:0007829|PDB:4I8H"
FT STRAND 76..80
FT /evidence="ECO:0007829|PDB:1C2D"
FT STRAND 81..84
FT /evidence="ECO:0007829|PDB:1EJM"
FT STRAND 86..95
FT /evidence="ECO:0007829|PDB:4I8H"
FT TURN 101..103
FT /evidence="ECO:0007829|PDB:4I8H"
FT STRAND 109..115
FT /evidence="ECO:0007829|PDB:4I8H"
FT STRAND 121..123
FT /evidence="ECO:0007829|PDB:5MN1"
FT STRAND 138..145
FT /evidence="ECO:0007829|PDB:4I8H"
FT STRAND 149..151
FT /evidence="ECO:0007829|PDB:4I8H"
FT STRAND 159..165
FT /evidence="ECO:0007829|PDB:4I8H"
FT HELIX 168..174
FT /evidence="ECO:0007829|PDB:4I8H"
FT TURN 176..178
FT /evidence="ECO:0007829|PDB:4I8H"
FT TURN 180..182
FT /evidence="ECO:0007829|PDB:1V2J"
FT STRAND 183..187
FT /evidence="ECO:0007829|PDB:4I8H"
FT STRAND 189..192
FT /evidence="ECO:0007829|PDB:4XOJ"
FT TURN 197..201
FT /evidence="ECO:0007829|PDB:1C1R"
FT STRAND 203..206
FT /evidence="ECO:0007829|PDB:4I8H"
FT STRAND 209..216
FT /evidence="ECO:0007829|PDB:4I8H"
FT STRAND 218..221
FT /evidence="ECO:0007829|PDB:4I8H"
FT STRAND 227..231
FT /evidence="ECO:0007829|PDB:4I8H"
FT HELIX 232..235
FT /evidence="ECO:0007829|PDB:4I8H"
FT HELIX 236..244
FT /evidence="ECO:0007829|PDB:4I8H"
SQ SEQUENCE 246 AA; 25785 MW; 092E3D8ACCCCC4D3 CRC64;
MKTFIFLALL GAAVAFPVDD DDKIVGGYTC GANTVPYQVS LNSGYHFCGG SLINSQWVVS
AAHCYKSGIQ VRLGEDNINV VEGNEQFISA SKSIVHPSYN SNTLNNDIML IKLKSAASLN
SRVASISLPT SCASAGTQCL ISGWGNTKSS GTSYPDVLKC LKAPILSDSS CKSAYPGQIT
SNMFCAGYLE GGKDSCQGDS GGPVVCSGKL QGIVSWGSGC AQKNKPGVYT KVCNYVSWIK
QTIASN
