ID   TRY3_CANAL              Reviewed;         494 AA.
AC   Q5A1M4; A0A1D8PN31;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Transcriptional regulator of yeast form adherence 3;
GN   Name=TRY3; OrderedLocusNames=CAALFM_C500980WA;
GN   ORFNames=CaO19.1971, CaO19.9527;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   INDUCTION.
RX   PubMed=22265407; DOI=10.1016/j.cell.2011.10.048;
RA   Nobile C.J., Fox E.P., Nett J.E., Sorrells T.R., Mitrovich Q.M.,
RA   Hernday A.D., Tuch B.B., Andes D.R., Johnson A.D.;
RT   "A recently evolved transcriptional network controls biofilm development in
RT   Candida albicans.";
RL   Cell 148:126-138(2012).
RN   [5]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=22359502; DOI=10.1371/journal.ppat.1002525;
RA   Finkel J.S., Xu W., Huang D., Hill E.M., Desai J.V., Woolford C.A.,
RA   Nett J.E., Taff H., Norice C.T., Andes D.R., Lanni F., Mitchell A.P.;
RT   "Portrait of Candida albicans adherence regulators.";
RL   PLoS Pathog. 8:E1002525-E1002525(2012).
CC   -!- FUNCTION: Transcription factor required for yeast cell adherence to
CC       silicone substrate. {ECO:0000269|PubMed:22359502}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- INDUCTION: Expression is induced in biofilm.
CC       {ECO:0000269|PubMed:22265407}.
CC   -!- DISRUPTION PHENOTYPE: Decreases cell adherence to silicone substrate.
CC       {ECO:0000269|PubMed:22359502}.
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DR   EMBL; CP017627; AOW29538.1; -; Genomic_DNA.
DR   RefSeq; XP_715733.2; XM_710640.2.
DR   AlphaFoldDB; Q5A1M4; -.
DR   SMR; Q5A1M4; -.
DR   STRING; 237561.Q5A1M4; -.
DR   PRIDE; Q5A1M4; -.
DR   GeneID; 3642652; -.
DR   KEGG; cal:CAALFM_C500980WA; -.
DR   CGD; CAL0000186243; TRY3.
DR   VEuPathDB; FungiDB:C5_00980W_A; -.
DR   eggNOG; KOG4159; Eukaryota.
DR   HOGENOM; CLU_017137_2_1_1; -.
DR   InParanoid; Q5A1M4; -.
DR   OrthoDB; 699787at2759; -.
DR   PRO; PR:Q5A1M4; -.
DR   Proteomes; UP000000559; Chromosome 5.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR004331; SPX_dom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF03105; SPX; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS51382; SPX; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..494
FT                   /note="Transcriptional regulator of yeast form adherence 3"
FT                   /id="PRO_0000426090"
FT   DOMAIN          1..360
FT                   /note="SPX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00714"
FT   ZN_FING         398..437
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ   SEQUENCE   494 AA;  57301 MW;  4D4562193BBB6CDD CRC64;
     MKFAKTLERT LEEDEIPQEW VEAAIQYKAL KKCINKVVNE LEFLGLQKNT LKILLNDKVV
     EVNEQETNPS NPIIAEYILS KTSTDAHNIK PMLKITLDYS SEDYTKDHIV ELGKELKQKI
     EALLNDSDTE YEEDKIIELK EDDGGDLQIV TSREGSLSPP ASRMASPPTS PTLKVVDSLN
     TNIDEALLSP DDHHKKHEIF IMLNSDSKFF EMLNDELNSL DTLTQQEESK IIEEVKKIAK
     YVNELKLKQS ELYKWRELFK VYLDSEVYFK YNETALPSQQ KSSEQIKSNL DLFVTNLNKS
     GIMTRFKKKQ SLETFNQFME MNYHLLKILQ FQTINNEALR KILKKFDKQT SLGIQKTFPK
     LISNDHIFMS GSSLAQSICY IIQESIIKVI PQLDDYSCPI CMNIAYKPIR LSCGHLFCVR
     CLVKMKQDDK TSCPLCRKEN AILYADSSNL DLESMELMKK YFPREVKEKL RERDKERYNE
     LRKNANSGEK CIVM