TRY4_CANAL
ID TRY4_CANAL Reviewed; 286 AA.
AC Q5ANC8; A0A1D8PK76;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Transcriptional regulator of yeast form adherence 4;
GN Name=TRY4; OrderedLocusNames=CAALFM_C305050WA;
GN ORFNames=CaO19.13396, CaO19.5975;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP INDUCTION.
RX PubMed=16151249; DOI=10.1128/ec.4.9.1562-1573.2005;
RA Murillo L.A., Newport G., Lan C.Y., Habelitz S., Dungan J., Agabian N.M.;
RT "Genome-wide transcription profiling of the early phase of biofilm
RT formation by Candida albicans.";
RL Eukaryot. Cell 4:1562-1573(2005).
RN [5]
RP INDUCTION.
RX PubMed=16024227; DOI=10.1016/j.resmic.2005.05.002;
RA Garcera A., Castillo L., Martinez A.I., Elorza M.V., Valentin E.,
RA Sentandreu R.;
RT "Anchorage of Candida albicans Ssr1 to the cell wall, and transcript
RT profiling of the null mutant.";
RL Res. Microbiol. 156:911-920(2005).
RN [6]
RP INDUCTION.
RX PubMed=22265407; DOI=10.1016/j.cell.2011.10.048;
RA Nobile C.J., Fox E.P., Nett J.E., Sorrells T.R., Mitrovich Q.M.,
RA Hernday A.D., Tuch B.B., Andes D.R., Johnson A.D.;
RT "A recently evolved transcriptional network controls biofilm development in
RT Candida albicans.";
RL Cell 148:126-138(2012).
RN [7]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22359502; DOI=10.1371/journal.ppat.1002525;
RA Finkel J.S., Xu W., Huang D., Hill E.M., Desai J.V., Woolford C.A.,
RA Nett J.E., Taff H., Norice C.T., Andes D.R., Lanni F., Mitchell A.P.;
RT "Portrait of Candida albicans adherence regulators.";
RL PLoS Pathog. 8:E1002525-E1002525(2012).
CC -!- FUNCTION: Transcription factor required for yeast cell adherence to
CC silicone substrate. {ECO:0000269|PubMed:22359502}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- INDUCTION: Expression is induced in biofilm and repressed by
CC fluconazole. Expression is also regulated by SS1.
CC {ECO:0000269|PubMed:16024227, ECO:0000269|PubMed:16151249,
CC ECO:0000269|PubMed:22265407}.
CC -!- DISRUPTION PHENOTYPE: Decreases cell adherence to silicone substrate.
CC {ECO:0000269|PubMed:22359502}.
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DR EMBL; CP017625; AOW28520.1; -; Genomic_DNA.
DR RefSeq; XP_723186.1; XM_718093.1.
DR AlphaFoldDB; Q5ANC8; -.
DR SMR; Q5ANC8; -.
DR BioGRID; 1218334; 1.
DR GeneID; 3635240; -.
DR KEGG; cal:CAALFM_C305050WA; -.
DR CGD; CAL0000199253; TRY4.
DR VEuPathDB; FungiDB:C3_05050W_A; -.
DR HOGENOM; CLU_083654_0_0_1; -.
DR InParanoid; Q5ANC8; -.
DR OMA; PRIYNCK; -.
DR OrthoDB; 455084at2759; -.
DR PRO; PR:Q5ANC8; -.
DR Proteomes; UP000000559; Chromosome 3.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:1900189; P:positive regulation of cell adhesion involved in single-species biofilm formation; IMP:CGD.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IMP:CGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:CGD.
DR GO; GO:0044011; P:single-species biofilm formation on inanimate substrate; IMP:CGD.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 2: Evidence at transcript level;
KW Cell adhesion; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..286
FT /note="Transcriptional regulator of yeast form adherence 4"
FT /id="PRO_0000426065"
FT ZN_FING 78..101
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 107..130
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 286 AA; 30945 MW; B33530ABD2EAFDEB CRC64;
MSLPMSPVSP INTTTSTSTT TTPLSPPSSI ENSSHPLSTS ISNNSITSDS SLDSNTSTSS
TTTTNYGTKT PSGNARIFNC TLCQRAFTRE EHLTRHTLST HNKLKPFTCG ICSRPFSRRD
LLLRHAKNLH QGSEVAVSRI RKSYKHCNKD NDSKSGSDSN TNKTNKNGKK QEQEDDEEEG
SRSDSSSGAD DEDSNTSSGG SNYHAIGSGN KRFVNNSPQL KKILTNGSVP STTTTSTTTV
PTSTNNDTAS ITNSSTSHIH QRSLNVEDYD TPEKKRLKMS VNMLVS
