TRY5_CANAL
ID TRY5_CANAL Reviewed; 988 AA.
AC Q5A4K7; A0A1D8PPN7;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Transcriptional regulator of yeast form adherence 5;
GN Name=TRY5; OrderedLocusNames=CAALFM_C601500CA;
GN ORFNames=CaO19.10938, CaO19.3434;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22359502; DOI=10.1371/journal.ppat.1002525;
RA Finkel J.S., Xu W., Huang D., Hill E.M., Desai J.V., Woolford C.A.,
RA Nett J.E., Taff H., Norice C.T., Andes D.R., Lanni F., Mitchell A.P.;
RT "Portrait of Candida albicans adherence regulators.";
RL PLoS Pathog. 8:E1002525-E1002525(2012).
CC -!- FUNCTION: Transcription factor required for yeast cell adherence to
CC silicone substrate. {ECO:0000269|PubMed:22359502}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Decreases cell adherence to silicone substrate.
CC {ECO:0000269|PubMed:22359502}.
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DR EMBL; CP017628; AOW30091.1; -; Genomic_DNA.
DR RefSeq; XP_716741.2; XM_711648.2.
DR AlphaFoldDB; Q5A4K7; -.
DR SMR; Q5A4K7; -.
DR GeneID; 3641619; -.
DR KEGG; cal:CAALFM_C601500CA; -.
DR CGD; CAL0000180184; TRY5.
DR VEuPathDB; FungiDB:C6_01500C_A; -.
DR HOGENOM; CLU_007678_0_0_1; -.
DR InParanoid; Q5A4K7; -.
DR OrthoDB; 455084at2759; -.
DR PRO; PR:Q5A4K7; -.
DR Proteomes; UP000000559; Chromosome 6.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 4: Predicted;
KW Cell adhesion; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..988
FT /note="Transcriptional regulator of yeast form adherence 5"
FT /id="PRO_0000426066"
FT ZN_FING 7..29
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 35..59
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 59..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 988 AA; 115741 MW; C083CEB7EB62CABF CRC64;
MAAQKKYICA FCARAFTRSE HKQRHERSHT NEKPFHCLHC TSSFVRRDLL QRHCRTVHHT
NLNPSTLPSN KSLKNPTTNP LDLSNNEGTT TTTKTGNRKN NSNKNGAKND KSTNPNPAVS
NDDNRSSVGD ITTQLPFQVQ FNTQLPYQQQ QQQQQQQQYP ILQNQGIPMK QSFSMESDQH
SLTTFDSPTS SLGVSMTPSG STNSEIVLQQ QQQTTKRRKR SQENNSNNNT KLIAKELNHD
LVHLLSITKK LTTLLQHYDN VKVNITDSFL IGYVHIQQQA KNFTIFEKIL KDLVYYLNTY
HINNLQQQNQ FPPSQQQNHY TINHFKIGIS YCVIALGFLI DHKPNRAIQF FKKSWNLLIK
TLIPQYNSNN NLLDQIEILY NLFLLCYIYL QFNLETFDIN EKQHEHHSYE QGDEHEDHHQ
EQVYINNQVI LNYLNDISFI IASNLKDVAT NNLIDHNLNL FWNIYILLSS YITKEPPKIH
QILLNKNLKQ NDTLVSLMQK FSKSFINMDM DDEQLKLVVV AALNNELKLY FNDTVDEFEP
ENSKNKRKFI YDNRNVLHNA IILINKSINF YNPSASLVND AKMFELKLFE LFKKNLIINS
PMKYHELFNN YIFIPQHYYH WQLLTLTLKE INQNNVIFNQ IHSILTTTTG SNVCFSFIDF
ENLLKNSFLN YKANPIVINN NLLIISYPII ILSNYLNLDN LMTSMGQMNQ LQFINLNIFI
IEWYLIMMKV LIIIWDDTLI DFEDNYILQT LMYILLDNKS CLLKRLNIDT SKLEYDVNCE
RLSFNQKWFW IIKLKFDSIF ENWMNFLKNK NNNVTNNSNV TNTSTTGITN TNHNHNDSYL
HHFNVNVSNF KFNLNKYLNE YFVTGDFKFR EQLDQNDPDQ FQGSMSMDEE PDFTTAMQTS
QTINSFMPIH NHNSRNQVYQ QHNQDTPMTS RRDSTNINEN NIAQTSSFIS NSNYQGSNSN
NMINYNEFQD RNYKRSSSIT LGILAQTV
