TRY6_CANAL
ID TRY6_CANAL Reviewed; 467 AA.
AC Q5ADL8; A0A1D8PKL6;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Transcriptional regulator of yeast form adherence 6;
GN Name=TRY6; OrderedLocusNames=CAALFM_C306790WA;
GN ORFNames=CaO19.14116, CaO19.6824;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP INDUCTION.
RX PubMed=16151249; DOI=10.1128/ec.4.9.1562-1573.2005;
RA Murillo L.A., Newport G., Lan C.Y., Habelitz S., Dungan J., Agabian N.M.;
RT "Genome-wide transcription profiling of the early phase of biofilm
RT formation by Candida albicans.";
RL Eukaryot. Cell 4:1562-1573(2005).
RN [5]
RP INDUCTION.
RX PubMed=16987174; DOI=10.1111/j.1365-2958.2006.05367.x;
RA Bennett R.J., Johnson A.D.;
RT "The role of nutrient regulation and the Gpa2 protein in the mating
RT pheromone response of C. albicans.";
RL Mol. Microbiol. 62:100-119(2006).
RN [6]
RP INDUCTION.
RX PubMed=22265407; DOI=10.1016/j.cell.2011.10.048;
RA Nobile C.J., Fox E.P., Nett J.E., Sorrells T.R., Mitrovich Q.M.,
RA Hernday A.D., Tuch B.B., Andes D.R., Johnson A.D.;
RT "A recently evolved transcriptional network controls biofilm development in
RT Candida albicans.";
RL Cell 148:126-138(2012).
RN [7]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22359502; DOI=10.1371/journal.ppat.1002525;
RA Finkel J.S., Xu W., Huang D., Hill E.M., Desai J.V., Woolford C.A.,
RA Nett J.E., Taff H., Norice C.T., Andes D.R., Lanni F., Mitchell A.P.;
RT "Portrait of Candida albicans adherence regulators.";
RL PLoS Pathog. 8:E1002525-E1002525(2012).
CC -!- FUNCTION: Transcription factor required for yeast cell adherence to
CC silicone substrate. {ECO:0000269|PubMed:22359502}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- INDUCTION: Expression is induced in biofilm and repressed by alpha
CC pheromone. {ECO:0000269|PubMed:16151249, ECO:0000269|PubMed:16987174,
CC ECO:0000269|PubMed:22265407}.
CC -!- DISRUPTION PHENOTYPE: Decreases cell adherence to silicone substrate.
CC {ECO:0000269|PubMed:22359502}.
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DR EMBL; CP017625; AOW28685.1; -; Genomic_DNA.
DR RefSeq; XP_719917.1; XM_714824.1.
DR AlphaFoldDB; Q5ADL8; -.
DR STRING; 237561.Q5ADL8; -.
DR PRIDE; Q5ADL8; -.
DR GeneID; 3638499; -.
DR KEGG; cal:CAALFM_C306790WA; -.
DR CGD; CAL0000178438; TRY6.
DR VEuPathDB; FungiDB:C3_06790W_A; -.
DR HOGENOM; CLU_033003_0_0_1; -.
DR InParanoid; Q5ADL8; -.
DR OMA; EMNETEN; -.
DR OrthoDB; 1433132at2759; -.
DR PRO; PR:Q5ADL8; -.
DR Proteomes; UP000000559; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:1900189; P:positive regulation of cell adhesion involved in single-species biofilm formation; IMP:CGD.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IMP:CGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:CGD.
DR GO; GO:0044011; P:single-species biofilm formation on inanimate substrate; IMP:CGD.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..467
FT /note="Transcriptional regulator of yeast form adherence 6"
FT /id="PRO_0000426068"
FT DOMAIN 92..173
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 43..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..417
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 467 AA; 51059 MW; CFD11CE2A8F6D1E5 CRC64;
MSLPSPPVLK TTIIQLNKEL DPEDDNNNYE ILTNDYNNYG SSNTSDAGSI PTSPIIEVSG
TTKSGSGLPN KKKRRRSTAN IDSEELAKRK NETKQLHSII EKRRRIKINR EFEALKYLIP
ACRNCNTGSS GGSATPTSST KKASTNSNNN GNKIDGMYKL TILKSSVEYI LYLHHIIQKQ
HQLLSSISAK DTNGGILAEK LKAFEDFDID FAKVPLNVNQ YRNIDKDFNF KDLMQDLDGR
SVNTESPETI IEENEPVSET SSTNNTTTLH YSNSSVLPSR TSSIVSSRQS SSLPTPELTP
ILSILNKYST SNNQLNNRKN SNPISPQTVC IKSQNPSPFT MPMKSSLSTS IVNSPSSSSS
LSGSKSYMAG NNAVNTVKFS LPDPVVNPNS TLNDNIPRKG LISGIPEEEE EEKINKGSAN
TETVNSGSAS SDENNDNDRG VLLKLTDQDV SKTLLALRKS SIDSLLN
