ID   TRYP_FELCA              Reviewed;          16 AA.
AC   P81071;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Trypsin;
DE            EC=3.4.21.4;
DE   Flags: Precursor; Fragment;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=9080665; DOI=10.1016/s0305-0491(96)00214-3;
RA   Steiner J.M., Medinger T.L., Williams D.A.;
RT   "Purification and partial characterization of feline trypsin.";
RL   Comp. Biochem. Physiol. 116B:87-93(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.4;
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
CC       Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00274}.
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DR   AlphaFoldDB; P81071; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Calcium; Digestion; Direct protein sequencing; Hydrolase; Protease;
KW   Reference proteome; Secreted; Serine protease; Zymogen.
FT   PROPEP          1..8
FT                   /note="Activation peptide"
FT                   /id="PRO_0000028195"
FT   CHAIN           9..>16
FT                   /note="Trypsin"
FT                   /id="PRO_0000028196"
FT   NON_TER         16
SQ   SEQUENCE   16 AA;  1825 MW;  A6D751BB58760A86 CRC64;
     FPIDDDDKIV GGYTNR