ID   TS11_GIAIN              Reviewed;         667 AA.
AC   Q03185;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Major surface trophozoite antigen 11;
DE   Flags: Precursor;
GN   Name=TSP11;
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate AD-1;
RX   PubMed=8479449; DOI=10.1016/0166-6851(93)90046-z;
RA   Ey P.L., Khanna K., Manning P.A., Mayrhofer G.;
RT   "A gene encoding a 69-kilodalton major surface protein of Giardia
RT   intestinalis trophozoites.";
RL   Mol. Biochem. Parasitol. 58:247-258(1993).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC       protein.
CC   -!- DOMAIN: Contains 27 repeats of a CXXC motif.
CC   -!- SIMILARITY: Belongs to the Giardia variant surface protein family.
CC       {ECO:0000305}.
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DR   EMBL; M95814; AAA02687.1; -; Genomic_DNA.
DR   PIR; A48579; A48579.
DR   AlphaFoldDB; Q03185; -.
DR   VEuPathDB; GiardiaDB:DHA2_154068; -.
DR   VEuPathDB; GiardiaDB:GL50581_2080; -.
DR   VEuPathDB; GiardiaDB:GL50581_2487; -.
DR   VEuPathDB; GiardiaDB:GL50803_00d115797; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR005127; Giardia_VSP.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   Pfam; PF03302; VSP; 1.
DR   SMART; SM00181; EGF; 5.
DR   SMART; SM00261; FU; 6.
DR   SUPFAM; SSF57184; SSF57184; 3.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; Membrane; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..17
FT   CHAIN           18..667
FT                   /note="Major surface trophozoite antigen 11"
FT                   /id="PRO_0000036460"
FT   TOPO_DOM        18..633
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        634..662
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        663..667
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        591
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        630
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   667 AA;  68476 MW;  1DD9572703232B8D CRC64;
     MLLAIFYFVI STLTAKCTTQ TQTCEAEKCE MVGETEICTR CQTGKVPIDG KCVDATANAN
     CKNASGDGDA NQVCGKMSSV PGNTLCTTVS PDGVCSVAAN EYFVPPNADA THDSVVSCSE
     ETPIHLANNK QYIGVAGCAT CSAPKAPGED NTPKAATCTK CAAGFLHTPS EGLSSCEETC
     PEGYFGHTAT AESKKTCKSC TGGSSEAPNV KGIGDCLKCM YNEASGNTLT CEKCSAQKKP
     SLDKTSCNDC TGQNCAFCSS SGGDCEGCDS GFILDGQNCV KSDCKTENCK ACTNPKAANE
     VCTECISTHH LTPTSQCVQY CQALGNYYAG TNADNKKACK ECTVANCKTC NDQGQCQTCN
     DGFYKNGDAC SPCHESCKTC SAGTASDCTE CPTGKALKYG NDGTKGTCGE GCTTGQGSGA
     CKTCGLTIDG ASYCSECDTQ NEYPQNGICT STTARTVATC KNSNVANGIC SSCTNGFLRM
     NGGCYETTKF PGKSVCEGAN ADADTCKAPV PGYKVEAGKL VMCSKGCDTC SDATTCTKCG
     DGYTKIENSQ TCTKCDSSCE TCTGAATTCK VCATGYYKTA LGESTCTSCE NDSNGVIGVK
     GCLNCAPPSS STGSVLCYLM KGENTGGSVN KSGLSTGAIA GISVAAVVVV AGLVGFLCWW
     FICRGKA