TS1R1_HUMAN
ID TS1R1_HUMAN Reviewed; 841 AA.
AC Q7RTX1; B2RMX0; Q5SY22; Q5SY24; Q8NGZ7; Q8TDJ7; Q8TDJ8; Q8TDJ9; Q8TDK0;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Taste receptor type 1 member 1;
DE AltName: Full=G-protein coupled receptor 70;
DE Flags: Precursor;
GN Name=TAS1R1; Synonyms=GPR70, T1R1, TR1; ORFNames=GM148;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLU-347.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 65-841 (ISOFORMS 1; 2; 3 AND 4), AND VARIANT
RP GLU-347.
RX PubMed=11891061; DOI=10.1016/s0378-1119(01)00897-6;
RA Makalowska I., Sood R., Faruque M.U., Hu P., Robbins C.M., Eddings E.M.,
RA Mestre J.D., Baxevanis A.D., Carpten J.D.;
RT "Identification of six novel genes by experimental validation of
RT GeneMachine predicted genes.";
RL Gene 284:203-213(2002).
RN [5]
RP IDENTIFICATION (ISOFORM 1), AND FUNCTION.
RX PubMed=11917125; DOI=10.1073/pnas.072090199;
RA Li X., Staszewski L., Xu H., Durick K., Zoller M., Adler E.;
RT "Human receptors for sweet and umami taste.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:4692-4696(2002).
CC -!- FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami
CC taste stimulus (the taste of monosodium glutamate). Sequence
CC differences within and between species can significantly influence the
CC selectivity and specificity of taste responses.
CC {ECO:0000269|PubMed:11917125}.
CC -!- SUBUNIT: Forms heterodimers with TAS1R3.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=Gm148 form B;
CC IsoId=Q7RTX1-1; Sequence=Displayed;
CC Name=2; Synonyms=Gm148 form C;
CC IsoId=Q7RTX1-2; Sequence=VSP_012418;
CC Name=3; Synonyms=Gm148 form A;
CC IsoId=Q7RTX1-3; Sequence=VSP_012418, VSP_012420;
CC Name=4; Synonyms=Gm148 form D;
CC IsoId=Q7RTX1-4; Sequence=VSP_012418, VSP_012421, VSP_012422;
CC -!- MISCELLANEOUS: [Isoform 4]: Incomplete sequence. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL91359.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAL91360.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAL91361.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC05845.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- SEQUENCE CAUTION: [Isoform 3]:
CC Sequence=AAL91358.1; Type=Frameshift; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=The taste experience - Issue
CC 55 of February 2005;
CC URL="https://web.expasy.org/spotlight/back_issues/055";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065618; BAC05845.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL591866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136515; AAI36516.1; -; mRNA.
DR EMBL; BC136516; AAI36517.1; -; mRNA.
DR EMBL; AF387617; AAL91358.1; ALT_SEQ; mRNA.
DR EMBL; AF387618; AAL91359.1; ALT_INIT; mRNA.
DR EMBL; AF387619; AAL91360.1; ALT_INIT; mRNA.
DR EMBL; AF387620; AAL91361.1; ALT_INIT; mRNA.
DR EMBL; BK000153; DAA00012.1; -; mRNA.
DR CCDS; CCDS81.1; -. [Q7RTX1-1]
DR CCDS; CCDS82.1; -. [Q7RTX1-2]
DR RefSeq; NP_619642.2; NM_138697.3. [Q7RTX1-1]
DR RefSeq; NP_803884.1; NM_177540.2. [Q7RTX1-2]
DR AlphaFoldDB; Q7RTX1; -.
DR SMR; Q7RTX1; -.
DR BioGRID; 123328; 3.
DR STRING; 9606.ENSP00000331867; -.
DR BindingDB; Q7RTX1; -.
DR ChEMBL; CHEMBL3832641; -.
DR TCDB; 9.A.14.7.5; the g-protein-coupled receptor (gpcr) family.
DR GlyGen; Q7RTX1; 6 sites.
DR iPTMnet; Q7RTX1; -.
DR PhosphoSitePlus; Q7RTX1; -.
DR BioMuta; TAS1R1; -.
DR DMDM; 57013075; -.
DR EPD; Q7RTX1; -.
DR PaxDb; Q7RTX1; -.
DR PeptideAtlas; Q7RTX1; -.
DR PRIDE; Q7RTX1; -.
DR Antibodypedia; 27421; 241 antibodies from 26 providers.
DR DNASU; 80835; -.
DR Ensembl; ENST00000333172.11; ENSP00000331867.6; ENSG00000173662.21. [Q7RTX1-1]
DR Ensembl; ENST00000351136.7; ENSP00000312558.5; ENSG00000173662.21. [Q7RTX1-2]
DR GeneID; 80835; -.
DR KEGG; hsa:80835; -.
DR MANE-Select; ENST00000333172.11; ENSP00000331867.6; NM_138697.4; NP_619642.2.
DR UCSC; uc001ant.4; human. [Q7RTX1-1]
DR CTD; 80835; -.
DR DisGeNET; 80835; -.
DR GeneCards; TAS1R1; -.
DR HGNC; HGNC:14448; TAS1R1.
DR HPA; ENSG00000173662; Tissue enriched (testis).
DR MIM; 606225; gene.
DR neXtProt; NX_Q7RTX1; -.
DR OpenTargets; ENSG00000173662; -.
DR PharmGKB; PA37882; -.
DR VEuPathDB; HostDB:ENSG00000173662; -.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00940000161264; -.
DR HOGENOM; CLU_005389_5_1_1; -.
DR InParanoid; Q7RTX1; -.
DR OMA; EDWAIST; -.
DR OrthoDB; 136715at2759; -.
DR PhylomeDB; Q7RTX1; -.
DR TreeFam; TF331269; -.
DR PathwayCommons; Q7RTX1; -.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR Reactome; R-HSA-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-HSA-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR BioGRID-ORCS; 80835; 11 hits in 1064 CRISPR screens.
DR ChiTaRS; TAS1R1; human.
DR GeneWiki; TAS1R1; -.
DR GenomeRNAi; 80835; -.
DR Pharos; Q7RTX1; Tbio.
DR PRO; PR:Q7RTX1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q7RTX1; protein.
DR Bgee; ENSG00000173662; Expressed in left testis and 81 other tissues.
DR ExpressionAtlas; Q7RTX1; baseline and differential.
DR Genevisible; Q7RTX1; HS.
DR GO; GO:0016021; C:integral component of membrane; IC:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0008527; F:taste receptor activity; IPI:UniProtKB.
DR GO; GO:0050917; P:sensory perception of umami taste; IDA:UniProtKB.
DR Gene3D; 2.10.50.30; -; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; PTHR24061; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Sensory transduction;
KW Signal; Taste; Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..841
FT /note="Taste receptor type 1 member 1"
FT /id="PRO_0000012954"
FT TOPO_DOM 21..567
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 568..588
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 589..603
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 604..624
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 625..639
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 640..660
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 661..680
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 681..701
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 702..725
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 726..746
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 747..761
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 762..782
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 783..795
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 796..816
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 817..841
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 291
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 479
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 529
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 167..420
FT /note="Missing (in isoform 2, isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:11891061"
FT /id="VSP_012418"
FT VAR_SEQ 421..841
FT /note="LLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWS
FT PVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKS
FT DLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAW
FT HLDTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCL
FT TVRSFQLIIIFKFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPARE
FT YQRFPHLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLL
FT FNFVSWIAFFTTASVYDGKYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEH
FT FQASIQDYTRRCGST -> LSYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKF
FT GWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQCLMRHLAQ
FT AGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAWALSRHITGVPGIQRIGMVLGV
FT AIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSSNQLCRECQAFMAHTMPKLKAFSM
FT SSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQTSTDASLVGKKSGHLREARPAS
FT RALWCFWLCVSTPLGCCWQLTRCCCCCCLGLLACLPGT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:11891061"
FT /id="VSP_012420"
FT VAR_SEQ 532..574
FT /note="DLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAAN -> ATWVR
FT TCQRTTTRTNVSPSACSSTSCPGSPSSPRPASTTAXTC (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:11891061"
FT /id="VSP_012421"
FT VAR_SEQ 575..841
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:11891061"
FT /id="VSP_012422"
FT VARIANT 347
FT /note="K -> E (in dbSNP:rs10864628)"
FT /evidence="ECO:0000269|PubMed:11891061,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_036707"
FT VARIANT 372
FT /note="A -> T (in dbSNP:rs34160967)"
FT /id="VAR_036708"
FT VARIANT 507
FT /note="R -> Q (in dbSNP:rs35118458)"
FT /id="VAR_036709"
FT CONFLICT 167
FT /note="I -> L (in Ref. 4; AAL91358)"
FT /evidence="ECO:0000305"
FT CONFLICT 648
FT /note="C -> W (in Ref. 4; AAL91360)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 841 AA; 93074 MW; E800772B267D0216 CRC64;
MLLCTARLVG LQLLISCCWA FACHSTESSP DFTLPGDYLL AGLFPLHSGC LQVRHRPEVT
LCDRSCSFNE HGYHLFQAMR LGVEEINNST ALLPNITLGY QLYDVCSDSA NVYATLRVLS
LPGQHHIELQ GDLLHYSPTV LAVIGPDSTN RAATTAALLS PFLVPMISYA ASSETLSVKR
QYPSFLRTIP NDKYQVETMV LLLQKFGWTW ISLVGSSDDY GQLGVQALEN QATGQGICIA
FKDIMPFSAQ VGDERMQCLM RHLAQAGATV VVVFSSRQLA RVFFESVVLT NLTGKVWVAS
EAWALSRHIT GVPGIQRIGM VLGVAIQKRA VPGLKAFEEA YARADKKAPR PCHKGSWCSS
NQLCRECQAF MAHTMPKLKA FSMSSAYNAY RAVYAVAHGL HQLLGCASGA CSRGRVYPWQ
LLEQIHKVHF LLHKDTVAFN DNRDPLSSYN IIAWDWNGPK WTFTVLGSST WSPVQLNINE
TKIQWHGKDN QVPKSVCSSD CLEGHQRVVT GFHHCCFECV PCGAGTFLNK SDLYRCQPCG
KEEWAPEGSQ TCFPRTVVFL ALREHTSWVL LAANTLLLLL LLGTAGLFAW HLDTPVVRSA
GGRLCFLMLG SLAAGSGSLY GFFGEPTRPA CLLRQALFAL GFTIFLSCLT VRSFQLIIIF
KFSTKVPTFY HAWVQNHGAG LFVMISSAAQ LLICLTWLVV WTPLPAREYQ RFPHLVMLEC
TETNSLGFIL AFLYNGLLSI SAFACSYLGK DLPENYNEAK CVTFSLLFNF VSWIAFFTTA
SVYDGKYLPA ANMMAGLSSL SSGFGGYFLP KCYVILCRPD LNSTEHFQAS IQDYTRRCGS
T
