TS1R1_RAT
ID TS1R1_RAT Reviewed; 840 AA.
AC Q9Z0R8;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Taste receptor type 1 member 1;
DE AltName: Full=G-protein coupled receptor 70;
DE Flags: Precursor;
GN Name=Tas1r1; Synonyms=Gpr70, T1r1, Tr1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Wistar; TISSUE=Circumvallate papilla;
RX PubMed=10052456; DOI=10.1016/s0092-8674(00)80658-3;
RA Hoon M.A., Adler E., Lindemeier J., Battey J.F., Ryba N.J.P., Zuker C.S.;
RT "Putative mammalian taste receptors: a class of taste-specific GPCRs with
RT distinct topographic selectivity.";
RL Cell 96:541-551(1999).
CC -!- FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami
CC taste stimulus (the taste of monosodium glutamate). Sequence
CC differences within and between species can significantly influence the
CC selectivity and specificity of taste responses.
CC -!- SUBUNIT: Forms heterodimers with TAS1R3.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in many cells in the fungiform and
CC geschmackstreifen taste buds. {ECO:0000269|PubMed:10052456}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000305}.
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DR EMBL; AF127389; AAD18069.1; -; mRNA.
DR RefSeq; NP_445757.1; NM_053305.1.
DR AlphaFoldDB; Q9Z0R8; -.
DR SMR; Q9Z0R8; -.
DR STRING; 10116.ENSRNOP00000013385; -.
DR GlyGen; Q9Z0R8; 7 sites.
DR PhosphoSitePlus; Q9Z0R8; -.
DR PaxDb; Q9Z0R8; -.
DR PRIDE; Q9Z0R8; -.
DR Ensembl; ENSRNOT00000013385; ENSRNOP00000013385; ENSRNOG00000009708.
DR GeneID; 29407; -.
DR KEGG; rno:29407; -.
DR UCSC; RGD:61891; rat.
DR CTD; 80835; -.
DR RGD; 61891; Tas1r1.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00940000161264; -.
DR HOGENOM; CLU_005389_5_1_1; -.
DR InParanoid; Q9Z0R8; -.
DR OMA; EDWAIST; -.
DR OrthoDB; 136715at2759; -.
DR PhylomeDB; Q9Z0R8; -.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR Reactome; R-RNO-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-RNO-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR PRO; PR:Q9Z0R8; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000009708; Expressed in adult mammalian kidney and 17 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IC:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0008527; F:taste receptor activity; IPI:UniProtKB.
DR GO; GO:0050917; P:sensory perception of umami taste; IDA:UniProtKB.
DR Gene3D; 2.10.50.30; -; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; PTHR24061; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Sensory transduction; Signal; Taste;
KW Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..840
FT /note="Taste receptor type 1 member 1"
FT /id="PRO_0000012956"
FT TOPO_DOM 20..566
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 567..587
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 588..602
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 603..623
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 624..638
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 639..659
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 660..679
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 680..700
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 701..724
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 725..745
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 746..760
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 761..781
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 782..786
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 787..807
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 808..840
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 86
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 94
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 290
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 478
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 528
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 840 AA; 93497 MW; 1FCFB7EFC6BB45DB CRC64;
MLFWAAHLLL SLQLVYCWAF SCQRTESSPG FSLPGDFLLA GLFSLHGDCL QVRHRPLVTS
CDRPDSFNGH GYHLFQAMRF TVEEINNSSA LLPNITLGYE LYDVCSESAN VYATLRVLAL
QGPRHIEIQK DLRNHSSKVV AFIGPDNTDH AVTTAALLGP FLMPLVSYEA SSVVLSAKRK
FPSFLRTVPS DRHQVEVMVQ LLQSFGWVWI SLIGSYGDYG QLGVQALEEL AVPRGICVAF
KDIVPFSARV GDPRMQSMMQ HLAQARTTVV VVFSNRHLAR VFFRSVVLAN LTGKVWVASE
DWAISTYITS VTGIQGIGTV LGVAVQQRQV PGLKEFEESY VRAVTAAPSA CPEGSWCSTN
QLCRECHTFT TRNMPTLGAF SMSAAYRVYE AVYAVAHGLH QLLGCTSEIC SRGPVYPWQL
LQQIYKVNFL LHENTVAFDD NGDTLGYYDI IAWDWNGPEW TFEIIGSASL SPVHLDINKT
KIQWHGKNNQ VPVSVCTTDC LAGHHRVVVG SHHCCFECVP CEAGTFLNMS ELHICQPCGT
EEWAPKESTT CFPRTVEFLA WHEPISLVLI AANTLLLLLL VGTAGLFAWH FHTPVVRSAG
GRLCFLMLGS LVAGSCSFYS FFGEPTVPAC LLRQPLFSLG FAIFLSCLTI RSFQLVIIFK
FSTKVPTFYR TWAQNHGAGL FVIVSSTVHL LICLTWLVMW TPRPTREYQR FPHLVILECT
EVNSVGFLLA FTHNILLSIS TFVCSYLGKE LPENYNEAKC VTFSLLLNFV SWIAFFTMAS
IYQGSYLPAV NVLAGLTTLS GGFSGYFLPK CYVILCRPEL NNTEHFQASI QDYTRRCGTT
