C3H12_ARATH
ID C3H12_ARATH Reviewed; 384 AA.
AC Q9LQM3; Q93ZP3;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=Zinc finger CCCH domain-containing protein 12;
DE Short=AtC3H12;
GN OrderedLocusNames=At1g32360; ORFNames=F27G20.10, F5D14.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NOMENCLATURE.
RX PubMed=18221561; DOI=10.1186/1471-2164-9-44;
RA Wang D., Guo Y., Wu C., Yang G., Li Y., Zheng C.;
RT "Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice.";
RL BMC Genomics 9:44-44(2008).
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DR EMBL; AC007767; AAF81332.1; -; Genomic_DNA.
DR EMBL; AC084110; AAG60171.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31468.1; -; Genomic_DNA.
DR EMBL; AK118013; BAC42646.1; -; mRNA.
DR EMBL; AY056407; AAL08263.1; -; mRNA.
DR EMBL; AY081710; AAL87363.1; -; mRNA.
DR PIR; D86448; D86448.
DR RefSeq; NP_564396.1; NM_102969.4.
DR AlphaFoldDB; Q9LQM3; -.
DR BioGRID; 25362; 1.
DR IntAct; Q9LQM3; 1.
DR STRING; 3702.AT1G32360.1; -.
DR iPTMnet; Q9LQM3; -.
DR PaxDb; Q9LQM3; -.
DR PRIDE; Q9LQM3; -.
DR ProteomicsDB; 239082; -.
DR EnsemblPlants; AT1G32360.1; AT1G32360.1; AT1G32360.
DR GeneID; 840128; -.
DR Gramene; AT1G32360.1; AT1G32360.1; AT1G32360.
DR KEGG; ath:AT1G32360; -.
DR Araport; AT1G32360; -.
DR TAIR; locus:2028306; AT1G32360.
DR eggNOG; KOG1677; Eukaryota.
DR HOGENOM; CLU_060653_1_0_1; -.
DR InParanoid; Q9LQM3; -.
DR OMA; EMWATEE; -.
DR OrthoDB; 883647at2759; -.
DR PhylomeDB; Q9LQM3; -.
DR PRO; PR:Q9LQM3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LQM3; baseline and differential.
DR Genevisible; Q9LQM3; AT.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR InterPro; IPR045877; ZFP36-like.
DR InterPro; IPR041367; Znf-CCCH_4.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR12547; PTHR12547; 2.
DR Pfam; PF00642; zf-CCCH; 2.
DR Pfam; PF18044; zf-CCCH_4; 1.
DR SMART; SM00356; ZnF_C3H1; 3.
DR SUPFAM; SSF90229; SSF90229; 3.
DR PROSITE; PS50103; ZF_C3H1; 3.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..384
FT /note="Zinc finger CCCH domain-containing protein 12"
FT /id="PRO_0000371971"
FT ZN_FING 91..118
FT /note="C3H1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 172..200
FT /note="C3H1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 260..288
FT /note="C3H1-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 46..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 11
FT /note="D -> G (in Ref. 4; AAL87363/AAL08263)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 384 AA; 40706 MW; 4F710F0327C467F3 CRC64;
MSHHRRDSGG DVVHVIPTNN PPPDNWFPNL GDSAVWATED DYNRAWAMNP DNTSGDNNGP
PNKKTRGSPS SSSATTTSAA SNRTKAIGKM FFKTKLCCKF RAGTCPYITN CNFAHTVEEL
RRPPPNWQEI VAAHEEERSG GMGTPTVSVV EIPREEFQIP SLVSSTAESG RSFKGRHCKK
FYTEEGCPYG ESCTFLHDEA SRNRESVAIS LGPGGYGSGG GGGSGGGSVG GGGSSSNVVV
LGGGGGSGSG SGIQILKPSN WKTRICNKWE ITGYCPFGAK CHFAHGAAEL HRFGGGLVEE
EGKDGVSPNP DTKQTVQNPK GLSDTTTLLS PGVPHNADAS YHTGVALQRA SSAVTQKPGI
RTHQKWKGPA KISRIYGDWI DDIE
