TS1R2_CANLF
ID TS1R2_CANLF Reviewed; 836 AA.
AC Q49HI0;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Taste receptor type 1 member 2;
DE AltName: Full=Sweet taste receptor T1R2;
DE Flags: Precursor;
GN Name=TAS1R2; Synonyms=T1R2;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16103917; DOI=10.1371/journal.pgen.0010003;
RA Li X., Li W., Wang H., Cao J., Maehashi K., Hong L., Bachmanov A.A.,
RA Reed D.R., Legrand-Defretin V., Beauchamp G.K., Brand J.G.;
RT "Pseudogenization of a sweet-receptor gene accounts for cats' indifference
RT toward sugar.";
RL PLoS Genet. 1:27-35(2005).
CC -!- FUNCTION: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse
CC natural and synthetic sweeteners (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms heterodimers with TAS1R3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000305}.
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DR EMBL; AY916758; AAX98691.1; -; mRNA.
DR RefSeq; NP_001026989.1; NM_001031819.1.
DR AlphaFoldDB; Q49HI0; -.
DR SMR; Q49HI0; -.
DR STRING; 9615.ENSCAFP00000022815; -.
DR PaxDb; Q49HI0; -.
DR GeneID; 478213; -.
DR KEGG; cfa:478213; -.
DR CTD; 80834; -.
DR eggNOG; KOG1056; Eukaryota.
DR eggNOG; KOG2455; Eukaryota.
DR InParanoid; Q49HI0; -.
DR OrthoDB; 136715at2759; -.
DR Proteomes; UP000002254; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR Gene3D; 2.10.50.30; -; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; PTHR24061; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Sensory transduction; Signal; Taste;
KW Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..836
FT /note="Taste receptor type 1 member 2"
FT /id="PRO_0000285549"
FT TOPO_DOM 20..565
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 566..586
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 587..601
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 602..622
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 623..634
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 635..655
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 656..680
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 681..701
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 702..724
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 725..745
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 746..757
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 758..778
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 779..781
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 782..802
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 803..836
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 292
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 312
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 351
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 427
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 479
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 486
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 526
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 546
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 836 AA; 94960 MW; CABF1E5E2152A723 CRC64;
MGPRAKAVCS LFILLQVLAE PAENSDFYLP GDYLLGGLFT LHANVKGTVH LSFLQVPQCK
KYEMKVLGYN LMQAMRFAVE EINNRSDLLP GVLLGYEIVD VCYISNNVQP VLYFLAREDY
SLPIQEDYSH YVPRVLAVIG PDNSESTTTV AHFLSLFLLP QITYSAISDD LRDKQHFPAL
LRTVAGADHQ IEAMVQLLLH FNWNWIIVLV SSDDYGRYNS QLLNDRLATG DICIAFQETL
PMPQPDQVVT EWERQRLEAI VGKLQQSSAR VVVLFSPDLI LHNFFREVLR QNFTGAVWIA
SESWAIDPVL HNLTELRQTG TFLGVTTQSV PIPGFSEFRI RRTPVRLPEP NRTSLEATCN
QECDTCQDTT ASFNSILMLS GERVVYNVYS AVYAVAHALH SLLGCTQACS KEVVYPWQLL
KEIWKVNFTL LGHNVFFGQQ GDVLMPMEVI QWQWDLSQNP FQSIASYYPK LRQLKAIHNI
SWHTANNTIP VSMCSKDCHP GQRKKPVGIH SCCFECIDCL PGTFLNRTAD EFDCQPCPSY
EWSHRNDTSC FKRRLAFLEW HEPSTIFVVM LTILGFLSTL AIMVIFWRHL HTPVVRSAGG
PMCFLMLVPL LLAYAMVPMY IGQPTFFSCL WRQTFFTLCF TICISCITVR SFQIVCIFKM
ARRLPRAYGY WVRCHGPYVF VASFMVLKVV IVAGNVLATT ANPTARPDPD DPNIMVLSCN
YRRALLFNTS LDLLLSVAGF SFAYMGKELP TNYNEAKFIT LCMTFYFTSS VSLCTFMSVY
DGVLVTILDL LITVLNLLGI SFGYFGPKCY MVLFYPERNT QVYFSSMIQG YTMGKD
