TS1R2_CEBPY
ID TS1R2_CEBPY Reviewed; 834 AA.
AC A3QP09;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 23-FEB-2022, entry version 40.
DE RecName: Full=Taste receptor type 1 member 2;
DE AltName: Full=Sweet taste receptor T1R2;
DE Flags: Precursor;
GN Name=TAS1R2;
OS Cebuella pygmaea (Pygmy marmoset) (Callithrix pygmaea).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Cebuella.
OX NCBI_TaxID=9493;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Li X., Wong E.W., Li W., Lim R., Mascioli K.J., Maehashi K.,
RA Bachmanov A.A., Tordoff M.G., Beauchamp G.K., Reed D.R.;
RT "Sweet receptor gene variation and aspartame blindness in both primates and
RT non-primates.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse
CC natural and synthetic sweeteners (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms heterodimers with TAS1R3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000305}.
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DR EMBL; DQ386302; ABD37686.1; -; Genomic_DNA.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR Gene3D; 2.10.50.30; -; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; PTHR24061; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Sensory transduction; Signal; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..834
FT /note="Taste receptor type 1 member 2"
FT /id="PRO_0000285550"
FT TOPO_DOM 20..561
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 562..582
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 583..597
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 598..618
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 619..630
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 631..651
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 652..676
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 677..697
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 698..722
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 723..743
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 744..755
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 756..776
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 777..779
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 780..800
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 801..834
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 292
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 312
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 363
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 423
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 482
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 522
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 834 AA; 94266 MW; 0EC9C9462B3B5970 CRC64;
MGPRARTVCF LFFLLWVLAE LAENSDFHLP GDYLLGGLFT LHANMKGIVH LNFLQVPMCK
EYEMKVSGYN LMQAMRFAVE EINNDSSLLP DVLLGYEMVD VCYISNNVQP ALYFLAQEDN
LLPIQEDYSN YVPRVVAVIG PENSESVMTV AHFLSLFLLP QITYSAISDQ LQDKQRFPAL
LRTTPSAKHH IEAMVQLMLH FHWNWISVLV SSDTYGRDNG QMLGDRLAGG DICIAFQETL
PTLQSNQDIM PEDHQRLVSI VEKLQQSTAR VVVVFSPDLS LYNFFREVLR QNFTGAVWIA
SESWAIDPVL HNLTGLHRTG TFLGITIQNV PIPGFSEFRV RGPQAGPTNQ RSTCNQECDT
CLNSTLSFNT VLRLSGERIV YSVYSAVYAV AHALHSLLGC DHSTCTKRVV YPWQLVQEIW
KVNFTLLDHQ IFFDPQGDVA LHLEIVQWQW DLSQNPFQSI ASYNPLQGRL KHIQDISWHT
INNTIPVSMC SKRCQSGQKK KPVGIHTCCF ECIDCLPGTF LNQTEDEYDC QACPSNEWSH
QSETSCFKRR LSFLEWHEAA TIAVALLAAL GFLXXXXXXX XXXXXXXXPM VRSAGGPMCF
LMLTLLLVAY MVVPVYVGPP KVTTCLCRQA LFPVCFTICI SCITMRSFQI VCVFKMASRF
PRAYSYWVRY QGSYVSVAFI TALKVVTVVI SLLATGLNPT TRADTDDPKI MIISCNPNYR
NSLLFNTSLD LLLSVVGFSF AYMGKELPTN YNEAKFITFS MTFYFTSSVS LCTFMSVYDG
VLVTIVDLLV TVFNLLAISL GYFGPKCYMI LFYPERNTPA YFNSMIQGYT MRRD
